Interrelationships between polygenic risk scores, cognition, symptoms, and functioning in first-episode psychosis: A network analysis approach.

Autor: Gil-Berrozpe GJ; Servicio de Psiquiatría, Hospital Universitario de Navarra, Pamplona, Spain; Instituto de Investigación Sanitaria de Navarra, Pamplona, , IdiSNA, Spain., Segura AG; Bipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona, Barcelona, Spain., Sánchez-Torres AM; Instituto de Investigación Sanitaria de Navarra, Pamplona, , IdiSNA, Spain; Department of Health Sciences, Universidad Pública de Navarra, Pamplona, Spain., Amoretti S; Department of Psychiatry, Hospital Universitari Vall d'Hebron; Group of Psychiatry, Mental Health and Addictions, Psychiatric Genetics Unit, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Biomedical Network Research Centre on Mental Health (CIBERSAM), Spain; Universitat Autònoma de Barcelona, Barcelona, Spain., Giné-Servén E; Department of Psychiatry, Hospital Universitario de Navarra, Pamplona, Spain., Vieta E; Bipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona, Barcelona, Spain; Biomedical Network Research Centre on Mental Health (CIBERSAM), Spain; Institute of Neurosciences, University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Mezquida G; Biomedical Network Research Centre on Mental Health (CIBERSAM), Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain; Barcelona Clínic Schizophrenia Unit, Hospital Clínic of Barcelona, Neuroscience Institute, Barcelona, Spain., Lobo A; Biomedical Network Research Centre on Mental Health (CIBERSAM), Spain; Department of Medicine and Psychiatry, Universidad de Zaragoza. Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain., Gonzalez-Pinto A; Biomedical Network Research Centre on Mental Health (CIBERSAM), Spain; BIOARABA, Department Psychiatry Hospital universitario de Alava, UPV/EHU, Vitoria, Spain., Andreu-Bernabeu A; Biomedical Network Research Centre on Mental Health (CIBERSAM), Spain; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, Madrid, Spain; School of Medicine, Universidad Complutense, Madrid, Spain., Roldán A; Biomedical Network Research Centre on Mental Health (CIBERSAM), Spain; Psychiatry Department, Hospital de la Santa Creu i Sant Pau, IIB SANT PAU, Barcelona, Spain., Forte MF; Bipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona, Barcelona, Spain; Biomedical Network Research Centre on Mental Health (CIBERSAM), Spain; Institute of Neurosciences, University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Castro J; Biomedical Network Research Centre on Mental Health (CIBERSAM), Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, Madrid, Spain; Department of Medicine, Institute of Neuroscience, University of Barcelona, Spain., Bergé D; Biomedical Network Research Centre on Mental Health (CIBERSAM), Spain; Hospital del Mar Research Institute, Universitat Pompeu Fabra, Barcelona, Spain., Rodríguez N; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain., Ballesteros A; Mental Health Department, Navarra Health Service - Osasunbidea, Pamplona, Spain., Mas S; Biomedical Network Research Centre on Mental Health (CIBERSAM), Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain. Electronic address: sergimash@ub.edu., Cuesta MJ; Servicio de Psiquiatría, Hospital Universitario de Navarra, Pamplona, Spain; Instituto de Investigación Sanitaria de Navarra, Pamplona, , IdiSNA, Spain. Electronic address: mcuestaz@navarra.es., Bernardo M; Biomedical Network Research Centre on Mental Health (CIBERSAM), Spain; Institute of Neurosciences, University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Barcelona Clínic Schizophrenia Unit, Hospital Clínic of Barcelona, Neuroscience Institute, Barcelona, Spain.

Publikováno v: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2024 Dec 24; Vol. 92, pp. 52-61. Date of Electronic Publication: 2024 Dec 24.

Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode

Autor: Segura, AG, Mezquida, G, Martinez-Pinteno, A, Gasso, P, Rodriguez, N, Moreno-Izco, L, Amoretti, S, Bioque, M, Lobo, A, Gonzalez-Pinto, A, Garcia-Alcon, A, Roldan-Bejarano, A, Vieta, E, de la Serna, E, Toll, A, Cuesta, MJ, Mas, S, Bernardo, M

Publikováno v: PSYCHOLOGICAL MEDICINE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Background Clinical intervention in early stages of psychotic disorders is crucial for the prevention of severe symptomatology trajectories and poor outcomes. Genetic variability is studied as a promising modulator of prognosis, thus novel approaches

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::2989d702242bfa0aab2af3612b549156
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11197

Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode.

Autor: Segura AG; Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain., Mezquida G; Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain.; Barcelona Clínic Schizophrenia Unit, Neuroscience Institute Hospital Clínic de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs), Barcelona, Spain., Martínez-Pinteño A; Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain., Gassó P; Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs), Barcelona, Spain., Rodriguez N; Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain., Moreno-Izco L; Department of Psychiatry, Complejo Hospitalario de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain., Amoretti S; Barcelona Clínic Schizophrenia Unit, Neuroscience Institute Hospital Clínic de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Group of Psychiatry, Mental Health and Addictions, Psychiatric Genetics Unit, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.; Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, Barcelona, Spain., Bioque M; Barcelona Clínic Schizophrenia Unit, Neuroscience Institute Hospital Clínic de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs), Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain., Lobo A; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Department of Medicine and Psychiatry, Universidad de Zaragoza, Zaragoza, Spain.; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain., González-Pinto A; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Hospital Universitario de Alava, Vitoria-Gasteiz, Spain.; Instituto de Investigación Sanitaria Bioaraba, Vitoria-Gasteiz, Spain.; University of the Basque Country, Vizcaya, Spain., García-Alcon A; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Roldán-Bejarano A; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Psychiatry Department, Institut d'Investigació Biomèdica-SantPau (IIB-SANTPAU), Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Vieta E; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain., de la Serna E; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs), Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.; Department of Child and Adolescent Psychiatry and Psychology, Clínic Institute of Neurosciences, University of Barcelona, Barcelona, Spain., Toll A; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Institute of Neuropsychiatry and Addiction, Parc de Salut Mar, Barcelona, Spain.; Hospital del Mar Medical Research Institute, Barcelona, Spain., Cuesta MJ; Department of Psychiatry, Complejo Hospitalario de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain., Mas S; Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs), Barcelona, Spain., Bernardo M; Barcelona Clínic Schizophrenia Unit, Neuroscience Institute Hospital Clínic de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs), Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.

Publikováno v: Psychological medicine [Psychol Med] 2023 Jul; Vol. 53 (10), pp. 4634-4647. Date of Electronic Publication: 2022 Jun 09.

Neurotoxic/Neuroprotective Effects of Clozapine and the Positive Allosteric Modulator of mGluR2 JNJ-46356479 in Human Neuroblastoma Cell Cultures.

Autor: Gassó P; Department of Basic Clinical Practice, University of Barcelona, 08036 Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), 28029 Madrid, Spain., Martínez-Pinteño A; Department of Basic Clinical Practice, University of Barcelona, 08036 Barcelona, Spain., Rodríguez N; Department of Basic Clinical Practice, University of Barcelona, 08036 Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Madero S; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), 28029 Madrid, Spain.; Barcelona Clínic Schizophrenia Unit (BCSU), Department of Psychiatry, Institute of Neuroscience, Hospital Clínic of Barcelona, University of Barcelona, 08036 Barcelona, Spain., Gómez M; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), 28029 Madrid, Spain.; Barcelona Clínic Schizophrenia Unit (BCSU), Department of Psychiatry, Institute of Neuroscience, Hospital Clínic of Barcelona, University of Barcelona, 08036 Barcelona, Spain., Segura AG; Department of Basic Clinical Practice, University of Barcelona, 08036 Barcelona, Spain., García-Rizo C; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), 28029 Madrid, Spain.; Barcelona Clínic Schizophrenia Unit (BCSU), Department of Psychiatry, Institute of Neuroscience, Hospital Clínic of Barcelona, University of Barcelona, 08036 Barcelona, Spain., Morén C; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Barcelona Clínic Schizophrenia Unit (BCSU), Department of Psychiatry, Institute of Neuroscience, Hospital Clínic of Barcelona, University of Barcelona, 08036 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 28029 Madrid, Spain., Mas S; Department of Basic Clinical Practice, University of Barcelona, 08036 Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), 28029 Madrid, Spain., Parellada E; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), 28029 Madrid, Spain.; Barcelona Clínic Schizophrenia Unit (BCSU), Department of Psychiatry, Institute of Neuroscience, Hospital Clínic of Barcelona, University of Barcelona, 08036 Barcelona, Spain.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 20; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 20.

Gene expression study in monocytes: evidence of inflammatory dysregulation in early-onset obsessive-compulsive disorder.

Autor: Rodríguez N; Department of Basic Clinical Practice, University of Barcelona, Barcelona, Spain. nrodriguezfe@ub.edu., Lázaro L; Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic de Barcelona, Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain., Ortiz AE; Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Morer A; Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain., Martínez-Pinteño A; Department of Basic Clinical Practice, University of Barcelona, Barcelona, Spain., Segura AG; Department of Basic Clinical Practice, University of Barcelona, Barcelona, Spain., Gassó P; Department of Basic Clinical Practice, University of Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain., Mas S; Department of Basic Clinical Practice, University of Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2022 Mar 31; Vol. 12 (1), pp. 134. Date of Electronic Publication: 2022 Mar 31.