Oral exposure to benzalkonium chlorides in male and female mice reveals alteration of the gut microbiome and bile acid profile.

Autor: Lopez VA; Department of Medicinal Chemistry., Lim JL; Department of Environmental and Occupational Health Sciences., Seguin RP; Department of Medicinal Chemistry., Dempsey JL; Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, WA, USA., Kunzman G; Department of Medicinal Chemistry., Cui JY; Department of Environmental and Occupational Health Sciences., Xu L; Department of Medicinal Chemistry.; Department of Environmental and Occupational Health Sciences.

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2024 Oct 03. Date of Electronic Publication: 2024 Oct 03.

Development and Application of a Multidimensional Database for the Detection of Quaternary Ammonium Compounds and Their Phase I Hepatic Metabolites in Humans.

Autor: Nguyen R; Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States., Seguin RP; Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States., Ross DH; Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States., Chen P; Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States., Richardson S; Department of Mathematics, University of Washington, Seattle, Washington 98195, United States., Liem J; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, United States., Lin YS; Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, United States., Xu L; Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, United States.

Publikováno v: Environmental science & technology [Environ Sci Technol] 2024 Apr 09; Vol. 58 (14), pp. 6236-6249. Date of Electronic Publication: 2024 Mar 27.

Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern.

Autor: Arnold WA; University of Minnesota, Minneapolis, Minnesota 55455, United States., Blum A; Green Science Policy Institute, Berkeley, California 94709, United States.; University of California, Berkeley, California 94720, United States., Branyan J; California Department of Toxic Substances Control, Sacramento, California 95814, United States., Bruton TA; California Department of Toxic Substances Control, Sacramento, California 95814, United States., Carignan CC; Michigan State University, East Lansing, Michigan 48824, United States., Cortopassi G; University of California, Davis, California 95616, United States., Datta S; University of California, Davis, California 95616, United States., DeWitt J; East Carolina University, Greenville, North Carolina 27834, United States., Doherty AC; California Department of Toxic Substances Control, Sacramento, California 95814, United States., Halden RU; Arizona State University, Tempe, Arizona 85287, United States., Harari H; Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States., Hartmann EM; Northwestern University, Evanston, Illinois 60208, United States., Hrubec TC; Edward Via College of Osteopathic Medicine, Blacksburg, Virginia 24060, United States., Iyer S; California Office of Environmental Health Hazard Assessment, Oakland, California 94612, United States., Kwiatkowski CF; Green Science Policy Institute, Berkeley, California 94709, United States.; North Carolina State University, Raleigh, North Carolina 27695 United States., LaPier J; Green Science Policy Institute, Berkeley, California 94709, United States., Li D; University of Nevada, Reno, Nevada 89557, United States., Li L; University of Nevada, Reno, Nevada 89557, United States., Muñiz Ortiz JG; US Public Health Service, Rockville, Maryland 20582, United States., Salamova A; Indiana University, Atlanta, Georgia 30322, United States., Schettler T; Science and Environmental Health Network, Bolinas, California 94924, United States., Seguin RP; University of Washington, Seattle, Washington 98195, United States., Soehl A; Green Science Policy Institute, Berkeley, California 94709, United States., Sutton R; San Francisco Estuary Institute, Richmond, California 94804, United States., Xu L; University of Washington, Seattle, Washington 98195, United States., Zheng G; Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.

Publikováno v: Environmental science & technology [Environ Sci Technol] 2023 May 23; Vol. 57 (20), pp. 7645-7665. Date of Electronic Publication: 2023 May 08.

Altered toxicological endpoints in humans from common quaternary ammonium compound disinfectant exposure.

Autor: Hrubec TC; Department of Biomedical Science, E. Via College of Osteopathic Medicine - Virginia, Blacksburg, VA, 24060, USA.; Department of Biomedical Science and Pathobiology, VA-MD College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, 24061, USA., Seguin RP; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, 98195, USA., Xu L; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, 98195, USA., Cortopassi GA; Department of Molecular Biosciences, School of Veterinary Medicine, University of California - Davis, Davis, CA, 95618, USA., Datta S; Department of Molecular Biosciences, School of Veterinary Medicine, University of California - Davis, Davis, CA, 95618, USA., Hanlon AL; Center for Biostatistics and Health Data Science, Department of Statistics, College of Science, Virginia Tech, Riverside Circle, Roanoke, VA, 24016, USA., Lozano AJ; Center for Biostatistics and Health Data Science, Department of Statistics, College of Science, Virginia Tech, Riverside Circle, Roanoke, VA, 24016, USA., McDonald VA; Department of Biomedical Science, E. Via College of Osteopathic Medicine - Virginia, Blacksburg, VA, 24060, USA., Healy CA; Department of Biomedical Science, E. Via College of Osteopathic Medicine - Virginia, Blacksburg, VA, 24060, USA., Anderson TC; Department of Biomedical Science, E. Via College of Osteopathic Medicine - Virginia, Blacksburg, VA, 24060, USA., Musse NA; Department of Biomedical Science, E. Via College of Osteopathic Medicine - Virginia, Blacksburg, VA, 24060, USA., Williams RT; Department of Biomedical Science, E. Via College of Osteopathic Medicine - Virginia, Blacksburg, VA, 24060, USA.

Publikováno v: Toxicology reports [Toxicol Rep] 2021 Mar 09; Vol. 8, pp. 646-656. Date of Electronic Publication: 2021 Mar 09 (Print Publication: 2021).

Quaternary Ammonium Compound Disinfectants Reduce Lupus-Associated Splenomegaly by Targeting Neutrophil Migration and T-Cell Fate.

Autor: Abdelhamid L; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States., Cabana-Puig X; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States., Mu Q; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States.; School of Medicine, Stanford University, Stanford, CA, United States., Moarefian M; Department of Mechanical Engineering, Virginia Tech, Blacksburg, VA, United States., Swartwout B; Translational Biology, Medicine and Health Graduate Program, Virginia Tech, Roanoke, VA, United States., Eden K; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States., Das P; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States., Seguin RP; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, United States., Xu L; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, United States., Lowen S; Department of Anatomical Sciences, Edward Via College of Osteopathic Medicine-Virginia Campus, Blacksburg, VA, United States., Lavani M; Department of Anatomical Sciences, Edward Via College of Osteopathic Medicine-Virginia Campus, Blacksburg, VA, United States., Hrubec TC; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States.; Department of Anatomical Sciences, Edward Via College of Osteopathic Medicine-Virginia Campus, Blacksburg, VA, United States., Jones CN; Department of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.; Department of Bioengineering, University of Texas, Dallas, TX, United States., Luo XM; Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2020 Oct 21; Vol. 11, pp. 575179. Date of Electronic Publication: 2020 Oct 21 (Print Publication: 2020).