Memory t cell proliferation before hepatitis c virus therapy predicts antiviral immune responses and treatment success

Autor: Méndez-Lagares, G, Lu, D, Chen, C, Terrault, N, Segal, MR, Khalili, M, Monto, A, Shen, H, Michele Manos, M, Lanier, LL, Ryan, JC, McCune, JM, Hartigan-O’Connor, DJ

Publikováno v: Méndez-Lagares, G; Lu, D; Chen, C; Terrault, N; Segal, MR; Khalili, M; et al.(2018). Memory t cell proliferation before hepatitis c virus therapy predicts antiviral immune responses and treatment success. Journal of Immunology, 200(3), 1124-1132. doi: 10.4049/jimmunol.1701364. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6s64x4gc

Copyright © 2018 by The American Association of Immunologists, Inc. The contribution of the host immune system to the efficacy of new anti-hepatitis C virus (HCV) drugs is unclear. We undertook a longitudinal prospective study of 33 individuals with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::deec51e024cab5906c20cd837bf30254
http://www.escholarship.org/uc/item/6s64x4gc

Serum biomarkers of treatment response within a randomized clinical trial for pulmonary tuberculosis

Autor: Jayakumar, A, Vittinghoff, E, Segal, MR, MacKenzie, WR, Johnson, JL, Gitta, P, Saukkonen, J, Anderson, J, Weiner, M, Engle, M, Yoon, C, Kato-Maeda, M, Nahid, P, Tuberculosis Trials Consortium

Publikováno v: Tuberculosis (Edinburgh, Scotland), vol 95, iss 4

RationaleBiomarkers for monitoring response to anti-tuberculosis treatment are needed. We explored immune markers previously published as having predictive capability for 8 week culture status in 39 adults enrolled in a clinical trial in Kampala, Uga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::8fb1524267d8fd62f29a83cd93792957
https://escholarship.org/uc/item/0hq3f1mk

Monocyte activation by interferon α Is associated with failure to achieve a sustained virologic response after treatment for hepatitis c virus infection

Autor: Hartigan-O'Connor, DJ, Lin, D, Ryan, JC, Shvachko, VA, Cozen, ML, Segal, MR, Terrault, NA, Lanier, LL, Manos, MM, McCune, JM

Publikováno v: Hartigan-O'Connor, DJ; Lin, D; Ryan, JC; Shvachko, VA; Cozen, ML; Segal, MR; et al.(2014). Monocyte activation by interferon α Is associated with failure to achieve a sustained virologic response after treatment for hepatitis c virus infection. Journal of Infectious Diseases, 209(10), 1602-1612. doi: 10.1093/infdis/jit801. UCSF: Retrieved from: http://www.escholarship.org/uc/item/7k72s56c

Background. Interferon α (IFN-α) and ribavirin can induce a sustained virologic response (SVR) in some but not all hepatitis C virus (HCV)-infected patients. The mechanism of effective treatment is unclear. One possibility is that IFN-α differenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::46f76562e52c918af44fccc99e6ad69f
http://www.escholarship.org/uc/item/7k72s56c

A histone arginine methylation localizes to nucleosomes in satellite II and III DNA sequences in the human genome

Autor: Segal, Mark, Capurso, D, Xiong, H, Segal, MR

Publikováno v: Segal, Mark; Capurso, D; Xiong, H; & Segal, MR. (2012). A histone arginine methylation localizes to nucleosomes in satellite II and III DNA sequences in the human genome. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2mh82789

Background: Applying supervised learning/classification techniques to epigenomic data may reveal properties that differentiate histone modifications. Previous analyses sought to classify nucleosomes containing histone H2A/H4 arginine 3 symmetric dime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::153ee10736d361a603d0c5d945da3c02
http://www.escholarship.org/uc/item/2mh82789

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