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pro vyhledávání: '"Segal, Brian"'
Clinical trials with a hybrid control arm (a control arm constructed from a combination of randomized patients and real-world data on patients receiving usual care in standard clinical practice) have the potential to decrease the cost of randomized t
Externí odkaz:
http://arxiv.org/abs/2108.08756
Autor:
Tan, W. Katherine, Segal, Brian D., Curtis, Melissa D., Baxi, Shrujal S., Capra, William B., Garrett-Mayer, Elizabeth, Hobbs, Brian P., Hong, David S., Hubbard, Rebecca A., Zhu, Jiawen, Sarkar, Somnath, Samant, Meghna
Randomized controlled trials (RCTs) are the gold standard for assessing drug safety and efficacy. However, RCTs have some drawbacks which have led to the use of single-arm studies to make certain internal drug development and regulatory decisions, pa
Externí odkaz:
http://arxiv.org/abs/2108.07335
Autor:
Segal, Brian D., Tan, W. Katherine
In situations where it is difficult to enroll patients in randomized controlled trials, external data can improve efficiency and feasibility. In such cases, adaptive trial designs could be used to decrease enrollment in the control arm of the trial b
Externí odkaz:
http://arxiv.org/abs/2010.00433
Autor:
Mathers, Cara, Black, Christopher K., Segal, Brian D., Gurung, Ram B., Zhang, Yao, Easter, Mark J., Williams, Stephen, Motew, Melissa, Campbell, Eleanor E., Brummitt, Charles D., Paustian, Keith, Kumar, Ashok A.
Publikováno v:
In Geoderma October 2023 438
Autor:
Segal, Brian D.
Several scientific fields including psychology are undergoing a replication crisis. There are many reasons for this problem, one of which is a misuse of p-values. There are several alternatives to p-values, and in this paper we describe a complement
Externí odkaz:
http://arxiv.org/abs/1803.03356
Autor:
Tan, W. Katherine, Segal, Brian D., Curtis, Melissa D., Baxi, Shrujal S., Capra, William B., Garrett-Mayer, Elizabeth, Hobbs, Brian P., Hong, David S., Hubbard, Rebecca A., Zhu, Jiawen, Sarkar, Somnath, Samant, Meghna
Publikováno v:
In Contemporary Clinical Trials Communications December 2022 30
Publikováno v:
Electronic Journal of Statistics. 12 (2018) 3554-3600
P-splines are penalized B-splines, in which finite order differences in coefficients are typically penalized with an $\ell_2$ norm. P-splines can be used for semiparametric regression and can include random effects to account for within-subject varia
Externí odkaz:
http://arxiv.org/abs/1707.08933
Publikováno v:
Biometrics. 74 (2018) 196-206
Researchers in genetics and other life sciences commonly use permutation tests to evaluate differences between groups. Permutation tests have desirable properties, including exactness if data are exchangeable, and are applicable even when the distrib
Externí odkaz:
http://arxiv.org/abs/1605.03992
Autor:
Harton, Joanna1 (AUTHOR), Segal, Brian2 (AUTHOR), Mamtani, Ronac3 (AUTHOR), Mitra, Nandita1 (AUTHOR), Hubbard, Rebecca A.1 (AUTHOR)
Publikováno v:
Statistics in Biopharmaceutical Research. Apr-Jun2023, Vol. 15 Issue 2, p408-420. 13p.
Publikováno v:
Biometrics, 2018 Mar 01. 74(1), 196-206.
Externí odkaz:
https://www.jstor.org/stable/45093164