Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Autor: Iannitelli, Alexa F., Segal, Arielle, Pare, Jean-Francoise, Mulvey, Bernard, Liles, L. Cameron, Sloan, Steven A., McCann, Katharine E., Dougherty, Joseph D., Smith, Yoland, Weinshenker, David

Publikováno v: bioRxiv

Motor symptoms in Parkinson’s disease (PD) are caused by degeneration of dopamine (DA) neurons of the substantia nigra (SN), while early non-motor symptoms such as anxiety and sleep disturbances are likely mediated by dysfunction of locus coeruleus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112f0d441bb71f912fbb3e956f8cdecd
https://doi.org/10.1101/2023.03.07.530845

Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus.

Autor: Iannitelli AF; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Hassenein L; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Mulvey B; Department of Psychiatry, Intellectual and Developmental Disabilities Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA.; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA., Blankenship HE; Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104., Liles LC; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Sharpe AL; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, 73117., Pare JF; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Segal A; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Sloan SA; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Martinowich K; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA., McCann KE; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Dougherty JD; Department of Psychiatry, Intellectual and Developmental Disabilities Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Smith Y; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Beckstead MJ; Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104., Weinshenker D; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 04. Date of Electronic Publication: 2024 Aug 04.