Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Sefinew Molla"'
1
PARP1-modulated chromatin remodeling is a new target for cancer treatment
Autor: Sefinew Molla, Chanakya Nath Kundu, Saptarshi Sinha
Publikováno v: Medical Oncology. 38
Cancer progression requires certain tumorigenic mutations in genes encoding for different cellular and nuclear proteins. Altered expressions of these mutated genes are mediated by post-translational modifications and chromatin remodeling. Chromatin r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4414655e751b5ed02fcf6b4450de3f47
https://doi.org/10.1007/s12032-021-01570-2
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2
Clinical significance of a pvrl 4 encoded gene Nectin-4 in metastasis and angiogenesis for tumor relapse
Autor: Chinmayee Sethy, Sefinew Molla, Deepika Nayak, Subhajit Chatterjee, Satya Narayan, Rajalaxmi Pradhan, Michael D. Wyatt, Kunal Goutam, Niranjan Rout, Chanakya Nath Kundu
Publikováno v: Journal of Cancer Research and Clinical Oncology. 146:245-259
In the present study, we have systematically examined the clinical significance of Nectin-4 (encoded by the PVRL-4 gene), a marker for breast cancer stem cells (CSCs), in cancer metastasis and angiogenesis using a variety of human specimens, includin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18cf373c0ce8d3016eb3341f256b7dfa
https://doi.org/10.1007/s00432-019-03055-2
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3
Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly
Autor: Sefinew Molla, Saptarshi Sinha, Chinmayee Sethy, Chanakya Nath Kundu, Subhajit Chatterjee
Publikováno v: DNA repair. 105
Apart from inducing catalytic inhibition of PARP-1, PARP inhibitors can also trap PARP proteins at the sites of DNA damage and forming toxic PARP-DNA complexes. These complexes obstruct the DNA repair process, resulting in cancer cell death. To study
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a995a2502d205ba8244c624cd30ef60a
https://pubmed.ncbi.nlm.nih.gov/34144488
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4
PARP inhibitor Olaparib Enhances the Apoptotic Potentiality of Curcumin by Increasing the DNA Damage in Oral Cancer Cells through Inhibition of BER Cascade
Autor: Krushna Chandra Hembram, Sefinew Molla, Chanakya Nath Kundu, Subhajit Chatterjee, Chinmayee Sethy, Deepika Nayak, Rajalaxmi Pradhan
Publikováno v: Pathology oncology research : POR. 26(4)
Although Olaparib (Ola, a PARP-inhibitor), in combination with other chemotherapeutic agents, was clinically approved to treat prostate cancer, but cytotoxicity, off-target effects of DNA damaging agents limit its applications in clinic. To improve t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43d379871c69894008c109a5c04c2cf
https://pubmed.ncbi.nlm.nih.gov/31768967
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5
Comparative and Mechanistic Study on the Anticancer Activity of Quinacrine-Based Silver and Gold Hybrid Nanoparticles in Head and Neck Cancer
Autor: Birendra Kumar Bindhani, Chanakya Nath Kundu, Deepika Nayak, Subhajit Chatterjee, Sefinew Molla, Chinmayee Sethy, Krushna Chandra Hembram, Rajalaxmi Pradhan
Publikováno v: Molecular pharmaceutics. 16(7)
Using oral cancer cells ( in vitro) and in vivo xenograft mice model, we have systematically studied the detailed mechanism of anticancer activity of quinacrine-based hybrid silver (QAgNP) and gold (QAuNP) nanoparticles (NPs) and compared their effic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ed4681c120c8f1192385009dd8cb98
https://pubmed.ncbi.nlm.nih.gov/32672463
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6
PARP inhibitor Veliparib (ABT-888) enhances the anti-angiogenic potentiality of Curcumin through deregulation of NECTIN-4 in oral cancer: Role of nitric oxide (NO)
Autor: Subhajit Chatterjee, Krushna Chandra Hembram, Sefinew Molla, Saptarshi Sinha, Chanakya Nath Kundu
Publikováno v: Cellular Signalling. 80:109902
Concurrent use of DNA damaging agents with PARP inhibitors contribute to the effectiveness of the anticancer therapy. But there is a dearth of reports on the antiangiogenic effects of PARP inhibitors and the suppression of angiogenesis by this drug c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700e3f3e080f73760061f7a543a1d02f
https://doi.org/10.1016/j.cellsig.2020.109902
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9
Seroprevalence of hepatitis B surface antigen and anti HCV antibody and its associated risk factors among pregnant women attending maternity ward of Felege Hiwot Referral Hospital, northwest Ethiopia: a cross-sectional study
Autor: Abaineh Munshea, Endalkachew Nibret, Sefinew Molla
Publikováno v: Virology Journal
Background Viral hepatitis is a life-threatening liver disease that has become important public health issue in developing countries including Ethiopia. This study was undertaken to determine the seroprevalence of HBsAgs and anti-HCV antibodies and w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba03189d2817700c937d366c70d2d6a
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