Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Sefan Asamitsu"'
Autor:
Sefan Asamitsu, Masayuki Takeuchi, Susumu Ikenoshita, Yoshiki Imai, Hirohito Kashiwagi, Norifumi Shioda
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 12, p 2884 (2019)
The most common form of DNA is a right-handed helix or the B-form DNA. DNA can also adopt a variety of alternative conformations, non-B-form DNA secondary structures, including the DNA G-quadruplex (DNA-G4). Furthermore, besides stem-loops that yield
Externí odkaz:
https://doaj.org/article/91de798d654b41a9a10af73ab0ff10eb
Publikováno v:
Molecules, Vol 24, Iss 3, p 429 (2019)
A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-rich sequences, and has profound implications for various pharmacological and biological events, including cancers. Therefore, ligands interacting with G4s have a
Externí odkaz:
https://doaj.org/article/112ab41f0e1d48e4865d87e8e76958c8
Autor:
Sefan Asamitsu, Yasushi Yabuki, Kazuya Matsuo, Moe Kawasaki, Yuki Hirose, Gengo Kashiwazaki, Anandhakumar Chandran, Toshikazu Bando, Dan Ohtan Wang, Hiroshi Sugiyama, Norifumi Shioda
Publikováno v:
Science Advances. 9
Consecutive guanine RNA sequences can adopt quadruple-stranded structures, termed RNA G-quadruplexes (rG4s). Although rG4-forming sequences are abundant in transcriptomes, the physiological roles of rG4s in the central nervous system remain poorly un
Autor:
Yousuke Katsuda, Shin-ichi Sato, Maimi Inoue, Hisashi Tsugawa, Takuto Kamura, Tomoki Kida, Rio Matsumoto, Sefan Asamitsu, Norifumi Shioda, Shuhei Shiroto, Yoshiki Oosawatsu, Kenji Yatsuzuka, Yusuke Kitamura, Masaki Hagihara, Toshihiro Ihara, Motonari Uesugi
Publikováno v:
Nucleic acids research. 50(14)
Tandem repeats of guanine-rich sequences in RNA often form thermodynamically stable four-stranded RNA structures. Such RNA G-quadruplexes have long been considered to be linked to essential biological processes, yet their physiological significance i
Publikováno v:
ChemBioChem. 23(2)
Abnormally expanded CAG/CTG repeat DNA sequences lead to a variety of neurological diseases, such as Huntington's disease. Here, we synthesized a cyclic pyrrole-imidazole polyamide (cPIP), which can bind to the minor groove of the CAG/CTG DNA sequenc
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2167-2171
Hairpin pyrrole–imidazole (Py-Im) polyamides are promising medium-sized molecules that bind sequence-specifically to the minor groove of B-form DNA. Here, we synthesized a series of hairpin Py-Im polyamides and explored their binding affinities and
Autor:
Tohru Matsuura, Sefan Asamitsu, Kohji Fukunaga, Kaori Adachi, Hiroshi Sugiyama, Kazuhiro Ishii, Shingo Usuki, Norifumi Shioda, Moe Kawasaki, Yasushi Yabuki, Hiroyuki Kugoh, Susumu Ikenoshita, Eiji Nanba, Yuji Nakayama, Kosuke Kawakubo
Publikováno v:
Science Advances
CGG repeat–derived RNA G-quadruplexes accelerate liquid-to-solid transition of FMRpolyG.
Fragile X-related tremor/ataxia syndrome (FXTAS) is a neurodegenerative disease caused by CGG triplet repeat expansions in FMR1, which elicit repeat-assoc
Fragile X-related tremor/ataxia syndrome (FXTAS) is a neurodegenerative disease caused by CGG triplet repeat expansions in FMR1, which elicit repeat-assoc
Autor:
Norifumi Shioda, Sefan Asamitsu
Publikováno v:
Journal of biochemistry. 169(5)
Cellular liquid–liquid phase separation is a physiologically inevitable phenomenon in molecularly crowded environments inside cells and serves to compartmentalize biomolecules to facilitate several functions, forming cytoplasmic and nuclear RNA gra
Autor:
Sefan Asamitsu, Hiroshi Sugiyama, Fumitaka Hashiya, Junichi Taniguchi, Ganesh N. Pandian, Mengting Ai, Zutao Yu, Kaori Hashiya, Toshikazu Bando, Soumen K. Samanta, Lyle Isaacs, Shuji Ikeda
Publikováno v:
Chemical communications (Cambridge, England). 56(15)
We developed an epigenetically active, cooperative DNA binding transcription factor platform assisted by cucurbit[7]uril (CB7) host–guest modules. This new type of molecule termed ePIP–HoGu not only mimics the operation of transcription factors a
Autor:
Yuki Tanoue, Masayuki Takeuchi, Hirohito Kashiwagi, Yasushi Yabuki, Susumu Ikenoshita, Norifumi Shioda, Yoshiki Imai, Takaichi Fukuda, Sefan Asamitsu
Publikováno v:
Biochemical and biophysical research communications. 531(1)
Guanine-rich DNA and RNA can form a four-stranded structure, termed G-quadruplexes (G4s) in vitro as well as in cells. The formation of G4 is implicated in many physiological events, such as gene transcription, translation, and epigenetics. However,