Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Seethu Xavy"'
Autor:
Jie Liu, Shirley Mihardja, Irving L. Weissman, Ravindra Majeti, Jens-Peter Volkmer, Balaji Agoram, Kavitha Sompalli, Sharline Chen, Seethu Xavy, Timothy S Choi, Dongdong Feng
Publikováno v:
JCI Insight
The CD47/signal regulatory protein α (Cd47/SIRPα)interaction provides a macrophage immune checkpoint pathway that plays a critical role in cancer immune evasion across multiple cancers. Here, we report the engineering of a humanized anti-SIRPα mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47165cdac3a638bd37ce609e8658616
https://pubmed.ncbi.nlm.nih.gov/32427583
https://pubmed.ncbi.nlm.nih.gov/32427583
Autor:
Suchita Rastogi, M. Ryan Corces-Zimmerman, Feifei Zhao, Wan-Jen Hong, Bruno C. Medeiros, Steven M. Chan, David A. Tyvoll, Daniel Thomas, Seethu Xavy, Ravindra Majeti
Publikováno v:
Nature Medicine. 21:178-184
Mutant isocitrate dehydrogenase (IDH) 1 and 2 proteins alter the epigenetic landscape in acute myeloid leukemia (AML) cells through production of the oncometabolite (R)-2-hydroxyglutarate (2-HG). Here we performed a large-scale RNA interference (RNAi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10e2e6768627cebeda9815d325220d2
https://doi.org/10.1038/nm.3788
https://doi.org/10.1038/nm.3788
Autor:
Andreas Reinisch, M. Ryan Corces, Rui Li, Seethu Xavy, Feifei Zhao, Jason D. Buenrostro, Ying Shen, Julie L. Koenig, Claire Mazumdar, Daniel Thomas, Ryan A. Flynn, Steven M. Chan, Howard Y. Chang, Ravindra Majeti, Wan-Jen Hong
SummaryRecurrent mutations in cohesin complex proteins have been identified in pre-leukemic hematopoietic stem cells and during the early development of acute myeloid leukemia and other myeloid malignancies. Although cohesins are involved in chromoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe447414e5d56e96573acc3132353f4
https://europepmc.org/articles/PMC4671831/
https://europepmc.org/articles/PMC4671831/
Autor:
Feng Lan, Susmita Chatterjee, Toshinobu Nishimura, Seethu Xavy, Jinfeng Shen, M. Ryan Corces, Joseph C. Wu, Soham Chanda, Rahul Sinha, Ravindra Majeti, Mark P. Chao, Rachel M. Morganti, Mohamed Ameen, Andreas Reinisch, Andrew J. Gentles, Haodi Wu, Daniel Haag, Marius Wernig
Publikováno v:
Cell Stem Cell. 20:329-344.e7
Understanding the relative contributions of genetic and epigenetic abnormalities to acute myeloid leukemia (AML) should assist integrated design of targeted therapies. In this study, we generated induced pluripotent stem cells (iPSCs) from AML patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b51986f3f6e1896ff1bcfebd378a2b1
https://doi.org/10.1016/j.stem.2016.11.018
https://doi.org/10.1016/j.stem.2016.11.018
Autor:
Nagaraja M, Phani, Shreeshakala, Acharya, Seethu, Xavy, Nalini, Bhaskaranand, Manoj K, Bhat, Aditya, Jain, Padmalatha S, Rai, Kapaettu, Satyamoorthy, Satyamoorthy, Kapaettu
Publikováno v:
Gene. 536(2)
Establishing genetic basis of Idiopathic generalized epilepsies (IGE) is challenging because of their complex inheritance pattern and genetic heterogeneity. Kir4.1 inwardly rectifying channel (KCNJ10) is one of the independent genes reported to be as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f038a33e2b19c573ad50c343a62a507
https://pubmed.ncbi.nlm.nih.gov/24378235
https://pubmed.ncbi.nlm.nih.gov/24378235
Autor:
Steven M. Chan, Wan-Jen Hong, Ravi Majeti, Andreas Reinisch, Seethu Xavy, Howard Y. Chang, Feifei Zhao, Julie L. Koenig, Michael Ryan Corces-Zimmerman, Claire Mazumdar, Ying Shen, Daniel Thomas, Jason D. Buenrostro, Rui Li
Publikováno v:
Blood. 126:841-841
Recurrent mutations in the components of the cohesin complex (RAD21, SMC1A, SMC3, and STAG2) have been identified in human AML and other myeloid malignancies, and have been shown to occur as pre-leukemic mutations in HSC. Cohesin functions to hold ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fc77a84bc650a1968f640ee3018ca49
https://doi.org/10.1182/blood.v126.23.841.841
https://doi.org/10.1182/blood.v126.23.841.841
Autor:
Aditya Jain, Manoj K. Bhat, Seethu Xavy, Kapaettu Satyamoorthy, Padmalatha S. Rai, Nagaraja M. Phani, Nalini Bhaskaranand, Shreeshakala Acharya
Publikováno v:
Gene. 539:285
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fd099b9a6551851d7176bfa18994631
https://doi.org/10.1016/j.gene.2014.02.005
https://doi.org/10.1016/j.gene.2014.02.005