Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation.

Autor: Pathmanapan S; Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada., Poon R; Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada., De Renshaw TB; Department of Orthopaedic Surgery, Duke University, Durham, NC, USA., Nadesan P; Department of Orthopaedic Surgery, Duke University, Durham, NC, USA., Nakagawa M; Department of Orthopaedic Surgery, Duke University, Durham, NC, USA., Seesankar GA; Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada., Ho Loe AK; Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada., Zhang HH; Department of Orthopaedic Surgery, Duke University, Durham, NC, USA., Guinovart JJ; Institute for Research in Biomedicine (IRB Barcelona) Barcelona, Barcelona, Spain., Duran J; Institute for Research in Biomedicine (IRB Barcelona) Barcelona, Barcelona, Spain., Newgard CB; Department of Pharmacology & Cancer Biology, Duke University, Durham, NC, USA; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA., Wunder JS; Lunenfeld-Tanenbaum Research Institute and the University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, ON, Canada., Alman BA; Department of Orthopaedic Surgery, Duke University, Durham, NC, USA. Electronic address: ben.alman@duke.edu.

Publikováno v: Cell reports [Cell Rep] 2023 Jun 27; Vol. 42 (6), pp. 112578. Date of Electronic Publication: 2023 Jun 01.