Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Seen-Ling Sim"'
Autor:
Kirat K. Chand, Jatin Patel, S. T. Bjorkman, Seen-Ling Sim, Stephanie M. Miller, Elliot Teo, Lara Jones, Jane Sun, Paul B. Colditz, Kiarash Khosrotehrani, Julie A. Wixey
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-15 (2021)
Abstract The foetal brain is particularly vulnerable to the detrimental effects of foetal growth restriction (FGR) with subsequent abnormal neurodevelopment being common. There are no current treatments to protect the FGR newborn from lifelong neurol
Externí odkaz:
https://doaj.org/article/e8b09f839fb949199093e3762d588305
Autor:
Jilai Zhao, Jatin Patel, Simranpreet Kaur, Seen-Ling Sim, Ho Yi Wong, Cassandra Styke, Isabella Hogan, Sam Kahler, Hamish Hamilton, Racheal Wadlow, James Dight, Ghazaleh Hashemi, Laura Sormani, Edwige Roy, Mervin C. Yoder, Mathias Francois, Kiarash Khosrotehrani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
How endothelial to mesenchymal transition is regulated in endovascular progenitors is unclear. Here, the authors show that blocking Sox9 expression in murine endovascular progenitors regulates this transition on skin wounding, affecting the size of s
Externí odkaz:
https://doaj.org/article/4916239cb44542b7875c762bd088d608
Autor:
Prudence Donovan, Jatin Patel, James Dight, Ho Yi Wong, Seen-Ling Sim, Valentine Murigneux, Mathias Francois, Kiarash Khosrotehrani
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The contribution of endothelial progenitor cells to tumor angiogenesis is controversial. Here, the authors trace the lineage differentiation of endovascular progenitor cells and demonstrate their functional importance in tumor vascularization and pro
Externí odkaz:
https://doaj.org/article/b472c48355de4681b6ea5ebc4841da96
Autor:
Samuel W. Lukowski, Jatin Patel, Stacey B. Andersen, Seen-Ling Sim, Ho Yi Wong, Joshua Tay, Ingrid Winkler, Joseph E. Powell, Kiarash Khosrotehrani
Publikováno v:
Cell Reports, Vol 27, Iss 9, Pp 2748-2758.e3 (2019)
Summary: The cellular and molecular profiles that govern the endothelial heterogeneity of the circulatory system have yet to be elucidated. Using a data-driven approach to study the endothelial compartment via single-cell RNA sequencing, we character
Externí odkaz:
https://doaj.org/article/dca508cce542418f9befa21d508d976c
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1659 (2022)
Macrophages regulate cutaneous wound healing by immune surveillance, tissue repair and remodelling. The depletion of dermal macrophages during the early and middle stages of wound healing has a detrimental impact on wound closure, characterised by re
Externí odkaz:
https://doaj.org/article/afba2bce55b84623a962dcef5bd0930a
Autor:
Julie A. Wixey, S. T. Bjorkman, Lara Jones, Seen-Ling Sim, Jatin Patel, Paul B. Colditz, Jane Sun, Kirat K. Chand, Elliot Teo, Kiarash Khosrotehrani, Stephanie M. Miller
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-15 (2021)
NPJ Regenerative Medicine
NPJ Regenerative Medicine
The foetal brain is particularly vulnerable to the detrimental effects of foetal growth restriction (FGR) with subsequent abnormal neurodevelopment being common. There are no current treatments to protect the FGR newborn from lifelong neurological di
Publikováno v:
Frontiers in Endocrinology. 13
Wnt signaling controls blood vessel growth, regression and patterning during embryonic and postnatal life. Macrophages are major producers of Wnt ligands and angiogenic growth factors. It regulates vascular development and specification during embryo
Autor:
James Dight, Sam L. Kahler, Edwige Roy, Ho Yi Wong, Jatin Patel, Hamish Hamilton, Racheal Wadlow, Mathias Francois, Isabella Hogan, Seen Ling Sim, Simranpreet Kaur, Laura Sormani, Kiarash Khosrotehrani, Mervin C. Yoder, Jilai Zhao, Ghazaleh Hashemi, Cassandra Styke
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Endothelial to mesenchymal transition (EndMT) is a leading cause of fibrosis and disease, however its mechanism has yet to be elucidated. The endothelium possesses a profound regenerative capacity to adapt and reorganize that is attributed to a popul
Publikováno v:
Frontiers in endocrinology. 13
Wnt signaling controls blood vessel growth, regression and patterning during embryonic and postnatal life. Macrophages are major producers of Wnt ligands and angiogenic growth factors. It regulates vascular development and specification during embryo