Výsledky vyhledávání - "Seemin Seher Ahmed"

Prenatal muscle forces are necessary for vertebral segmentation and disc structure, but not for notochord involution in mice

Autor: D-M Kaimaki, Seemin Seher Ahmed, James C. Iatridis, Niamh C. Nowlan, A Levillain, S Barros, S Schuler, David Labonte

Publikováno v: European Cells & Materials, Vol 41, Pp 558-575 (2021)
European cells & materials

Embryonic muscle forces are necessary for normal vertebral development and spinal curvature, but their involvement in intervertebral disc (IVD) development remains unclear. The aim of the current study was to determine how muscle contractions affect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee368522b4d7d6b8a30c3887e7bd5885
https://doi.org/10.22203/ecm.v041a36

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Sustained Correction of a Murine Model of Phenylketonuria following a Single Intravenous Administration of AAVHSC15-PAH

Autor: Minglun Wang, Hillard Rubin, Jason Lotterhand, Omar L. Francone, Maria Lobikin, Seemin Seher Ahmed, Albert B. Seymour, Diana Lamppu, Laura Adamson-Small, Serena Nicole Dollive, Jeff L. Ellsworth, Teresa Leah Wright, Nancy Avila, Arnold Sengooba, Deiby Faulkner

Publikováno v: Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 568-580 (2020)

Phenylketonuria is an inborn error of metabolism caused by loss of function of the liver-expressed enzyme phenylalanine hydroxylase and is characterized by elevated systemic phenylalanine levels that are neurotoxic. Current therapies do not address t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee594b97971736e6cac44a5e716935cf
https://pubmed.ncbi.nlm.nih.gov/32258219

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Initiation and emerging complexity of the collagen network during prenatal skeletal development

Autor: Niamh C. Nowlan, Seemin Seher Ahmed

Publikováno v: European Cells & Materials, Vol 39, Pp 136-155 (2020)

The establishment of a complex collagen network is critical for the architecture and mechanical properties of cartilage and bone. However, when and how the key collagens in cartilage and bone develop has not been characterised in detail. The study pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3790c78a655e40878c58da8694e02ca7
http://hdl.handle.net/10044/1/77293

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rAAV Gene Therapy in a Canavan's Disease Mouse Model Reveals Immune Impairments and an Extended Pathology Beyond the Central Nervous System

Autor: Qin Su, Elif M. Sikoglu, Daniel A. Kirschner, Jia Li, Reuben Matalon, Thomas G Hampton, Seemin Seher Ahmed, Andrew R. Denninger, Brian K. Kaspar, Stefan A. Schattgen, Guangping Gao, Ashley E. Frakes

Publikováno v: Molecular Therapy. 24:1030-1041

Aspartoacylase (AspA) gene mutations cause the pediatric lethal neurodegenerative Canavan disease (CD). There is emerging promise of successful gene therapy for CD using recombinant adeno-associated viruses (rAAVs). Here, we report an intracerebroven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3cb26654d2cbc4e18d8e122796ff72a
https://doi.org/10.1038/mt.2016.68

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Single intravenous dose of AAVHSC15 vector with human phenylalanine hydroxylase transgene results in sustained correction of phenylketonuria in the PAH mouse model

Autor: Hillard Rubin, Diana Lamppu, Omar L. Francone, Deiby Faulkner, Serena Nicole Dollive, Seemin Seher Ahmed, Arnold Sengooba, Jeff L. Ellsworth, Albert B. Seymour, Teresa Leah Wright

Publikováno v: Molecular Genetics and Metabolism. 126:S56

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::165e0556fbc7c88540b93927a6a63bb2
https://doi.org/10.1016/j.ymgme.2018.12.129

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A Single Intravenous rAAV Injection as Late as P20 Achieves Efficacious and Sustained CNS Gene Therapy in Canavan Mice

Autor: Daniel A. Kirschner, Constance M. Moore, Thomas N. Seyfried, Elif M. Sikoglu, Huapeng Li, Reuben Matalon, Jun Xie, Sylvia Szucs, Terence R. Flotte, Ana A. Liso Navarro, Andrew R. Denninger, Guangping Gao, Hongwei Zhang, Samuel Eaton, Seemin Seher Ahmed, Chunyan Cao, Qin Su

Publikováno v: Molecular Therapy. 21:2136-2147

Canavan's disease (CD) is a fatal pediatric leukodystrophy caused by mutations in aspartoacylase (AspA) gene. Currently, there is no effective treatment for CD; however, gene therapy is an attractive approach to ameliorate the disease. Here, we studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909841e3b2242fd785a839a676201b74
https://doi.org/10.1038/mt.2013.138

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Examination of the Blood Brain Barrier integrity in a mouse model of the neurodegenerative Canavan's disease

Autor: Seemin Seher Ahmed, Guangping Gao

Publikováno v: Journal of neurological disorders. 2(6)

The blood brain barrier (BBB) refers to the complex anatomical barrier in the brain composed of endothelial cells, astroglia, pericytes, perivascular macrophages and basal lamina. Its selectivity controls the entry of substances into the Central Nerv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b08c0b2e0fd09d82a13ae59d4b53c9e
https://pubmed.ncbi.nlm.nih.gov/26550581

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Global CNS Transduction of Adult Mice by Intravenously Delivered rAAVrh.8 and rAAVrh.10 and Nonhuman Primates by rAAVrh.10

Autor: Joshua A. Kramer, Chunyan Cao, Qin Su, Dominic J. Gessler, Ran He, Seemin Seher Ahmed, Guangping Gao, Shaoyong Li, Robert H. Brown, Ronald C. Desrosiers, Bin Yang, Hongwei Zhang, Li Zhong, Zuoshang Xu, Hongyan Wang, Yansu Guo

Some recombinant adeno-associated viruses (rAAVs) can cross the neonatal blood–brain barrier (BBB) and efficiently transduce cells of the central nervous system (CNS). However, in the adult CNS, transduction levels by systemically delivered rAAVs a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029fececbc9386e92e3095b7fc1b6c54
https://europepmc.org/articles/PMC4089005/

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Making the White Matter Matters: Progress in Understanding Canavan's Disease and Therapeutic Interventions Through Eight Decades

Autor: Guangping Gao, Seemin Seher Ahmed

Publikováno v: JIMD Reports ISBN: 9783662461891

Canavan’s disease (CD) is a fatal autosomal recessive pediatric leukodystrophy in which patients show severe neurodegeneration and typically die by the age of 10, though life expectancy in patients can be highly variable. Currently, there is no eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe10baf24797a12d7e29fdceed4bfc3
https://pubmed.ncbi.nlm.nih.gov/25604619

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Gene Transfer to the CNS Using Recombinant Adeno‐Associated Virus

Autor: Seemin Seher Ahmed, Guangping Gao, Lorelei Stoica, Miguel Sena-Esteves

Publikováno v: Current Protocols in Microbiology

Recombinant adeno associated virus (rAAV) vectors are great tools for gene transfer due to their ability to mediate long-term gene expression. Recombinant AAVs have been used at various ages of development with no apparent toxicity. There are multipl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6db8c30f654e93e88abae82a68876305
https://doi.org/10.1002/9780471729259.mc14d05s29

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