Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Seemana, Bhattacharya"'
Autor:
Weiguo Zhang, Guopan Yu, Hongying Zhang, Mahesh Basyal, Charlie Ly, Bin Yuan, Vivian Ruvolo, Sujan Piya, Seemana Bhattacharya, Qi Zhang, Gautam Borthakur, Venkata Battula, Marina Konopleva, William G. Rice, Michael Andreeff
Publikováno v:
Haematologica, Vol 108, Iss 6 (2022)
Strategies to overcome resistance to FMS-like tyrosine kinase 3 (FLT3)-targeted therapy in acute myeloid leukemia (AML) are urgently needed. We identified autophagy as one of the resistance mechanisms, induced by hypoxia and the bone marrow microenvi
Externí odkaz:
https://doaj.org/article/fc214a4663764cf4a1afa569299e8742
Autor:
Seemana Bhattacharya, Sujan Piya, Huaxian Ma, Priyanka Sharma, Qi Zhang, Natalia Baran, Vivian R. Ruvolo, Teresa McQueen, R. Eric Davis, Rasoul Pourebrahim, Marina Konopleva, Hagop Kantarjian, Nicholas D. P. Cosford, Michael Andreeff, Gautam Borthakur
Publikováno v:
Molecular Cancer Research. 21:548-563
Despite effective new therapies, adaptive resistance remains the main obstacle in acute myelogenous leukemia (AML) therapy. Autophagy induction is a key mechanism for adaptive resistance. Leukemic blasts at diagnosis express higher levels of the apic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9a5c832416503f974f37b6633499ecf
https://doi.org/10.1158/1541-7786.mcr-22-0343
https://doi.org/10.1158/1541-7786.mcr-22-0343
Autor:
Gautam Borthakur, Michael Andreeff, Nicholas D. P. Cosford, Hagop Kantarjian, Marina Konopleva, Rasoul Pourebrahim, R. Eric Davis, Teresa McQueen, Vivian R. Ruvolo, Natalia Baran, Qi Zhang, Priyanka Sharma, Huaxian Ma, Sujan Piya, Seemana Bhattacharya
Supplementary Table S1. Abbreviations of cell populations analyzed using Bloodspot. Supplementary Table S2. Comparative analysis of significance based on survival curves generated using GraphPad. Supplementary Table S3. Mutational profiles of AML cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435eee18836ae5e671c247e980580b6a
https://doi.org/10.1158/1541-7786.22354231
https://doi.org/10.1158/1541-7786.22354231
Autor:
Gautam Borthakur, Michael Andreeff, Nicholas D. P. Cosford, Hagop Kantarjian, Marina Konopleva, Rasoul Pourebrahim, R. Eric Davis, Teresa McQueen, Vivian R. Ruvolo, Natalia Baran, Qi Zhang, Priyanka Sharma, Huaxian Ma, Sujan Piya, Seemana Bhattacharya
S1. Effect of genetic abrogation of ULK1 in vitro and in vivo. S2. ULK1 inhibitor SBI-0206965 has anti-leukemic activity and can overcome autophagic adaptation in drug-resistant cells. S3. ULK1 inhibition reverses drug-resistance and synergizes with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9360f17846f0cceb94c58e29d5c2f719
https://doi.org/10.1158/1541-7786.22354234
https://doi.org/10.1158/1541-7786.22354234
Autor:
Gautam Borthakur, Michael Andreeff, Nicholas D. P. Cosford, Hagop Kantarjian, Marina Konopleva, Rasoul Pourebrahim, R. Eric Davis, Teresa McQueen, Vivian R. Ruvolo, Natalia Baran, Qi Zhang, Priyanka Sharma, Huaxian Ma, Sujan Piya, Seemana Bhattacharya
Despite effective new therapies, adaptive resistance remains the main obstacle in acute myelogenous leukemia (AML) therapy. Autophagy induction is a key mechanism for adaptive resistance. Leukemic blasts at diagnosis express higher levels of the apic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3c99bcedd03d3e4397c9e520053e49
https://doi.org/10.1158/1541-7786.c.6491044.v1
https://doi.org/10.1158/1541-7786.c.6491044.v1
Autor:
Weiguo Zhang, Guopan Yu, Hongying Zhang, Mahesh Basyal, Charlie Ly, Bin Yuan, Vivian Ruvolo, Sujan Piya, Seemana Bhattacharya, Qi Zhang, Gautam Borthakur, Venkata Battula, Marina Konopleva, William G. Rice, Michael Andreeff
Publikováno v:
Haematologica.
Strategies to overcome resistance to FMS-like tyrosine kinase 3 (FLT3)-targeted therapy in acute myeloid leukemia (AML) are urgently needed. We identified autophagy as one of the resistance mechanisms, induced by hypoxia and the bone marrow microenvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05ee87d8e28f43037d4e9202c66ad64
https://pubmed.ncbi.nlm.nih.gov/36226489
https://pubmed.ncbi.nlm.nih.gov/36226489
Autor:
Sujan Piya, Yaling Yang, Seemana Bhattacharya, Priyanka Sharma, Huaxian Ma, Hong Mu, Hua He, Vivian Ruvolo, Natalia Baran, R. Eric Davis, Abhinav K. Jain, Marina Konopleava, Hagop Kantarjian, Michael Andreeff, M. James You, Gautam Borthakur
Publikováno v:
Leukemia. 36(5)
The NOTCH1-MYC-CD44 axis integrates cell-intrinsic and extrinsic signaling to ensure the persistence of leukemia-initiating cells (LICs) in T-cell acute lymphoblastic leukemia (T-ALL) but a common pathway to target this circuit is poorly defined. Bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56a5f1a06350eb078374aa12a5a433d
https://pubmed.ncbi.nlm.nih.gov/35173274
https://pubmed.ncbi.nlm.nih.gov/35173274
Autor:
Arijit Bhowmik, Nilanjana Das, Uttam Pal, Madhumita Mandal, Seemana Bhattacharya, Moumita Sarkar, Parasuraman Jaisankar, Nakul C Maiti, Mrinal K Ghosh
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59798 (2013)
Despite recent advances in medicine, 30-40% of patients with breast cancer show recurrence underscoring the need for improved effective therapy. In this study, by in vitro screening we have selected a novel synthetic indole derivative 2,2'-diphenyl-3
Externí odkaz:
https://doaj.org/article/3aa39d79e65245f7bfda713766dd5396
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 3, Iss 1, Pp 1-12 (2018)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Herpesvirus-associated ubiquitin-specific protease (HAUSP) is a USP family deubiquitinase. HAUSP is a protein of immense biological importance as it is involved in several cellular processes, including host-virus interactions, oncogenesis and tumor s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a6318bf9ccc829eb2ed64e01745712
http://link.springer.com/article/10.1038/s41392-018-0012-y
http://link.springer.com/article/10.1038/s41392-018-0012-y
Autor:
Yimin Qian, Vivian Ruvolo, Seemana Bhattacharya, Sujan Piya, Michael Andreeff, Marina Konopleva, R. Eric Davis, Philip L. Lorenzi, Hong Mu, Teresa McQueen, Hagop M. Kantarjian, Natalia Baran, M. James You, Gautam Borthakur, Zhiqiang Wang, Jo Ishizawa, Craig M. Crews
Publikováno v:
The Journal of clinical investigation. 129(5)
The antileukemic effect of inhibiting bromodomain and extra-terminal domain-containing (BET-containing) proteins (BETPs) such as BRD4 has largely been largely attributed to transcriptional downregulation of cellular anabolic and antiapoptotic process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f222cf2cc0f3bdb337c2cdc9541fb2
https://pubmed.ncbi.nlm.nih.gov/30829648
https://pubmed.ncbi.nlm.nih.gov/30829648