Zobrazeno 1 - 10
of 403
pro vyhledávání: '"Seema A, Khan"'
Publikováno v:
Genes and Environment, Vol 45, Iss 1, Pp 1-11 (2023)
Abstract The number of breast cancer patients is increasing worldwide. Furthermore, breast cancer often develops in young people, even those only in their 30s, who play a central role in their families and society. Results from many cohort studies su
Externí odkaz:
https://doaj.org/article/9bc087b6b41a40a2b99bcd179f9455b3
Autor:
Oukseub Lee, Latifa A. Bazzi, Yanfei Xu, Erik Pearson, Minhua Wang, Omid Hosseini, Azza M. Akasha, Jennifer Nam Choi, Scott Karlan, Melissa Pilewskie, Masha Kocherginsky, Kelly Benante, Thomas Helland, Gunnar Mellgren, Eileen Dimond, Marjorie Perloff, Brandy M. Heckman-Stoddard, Seema A. Khan
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116105- (2024)
Breast cancer prevention only requires local exposure of the breast to active drug. However, oral preventive agents entail systemic exposure, causing adverse effects that limit acceptance by high-risk women. Drug-delivery through the breast skin is a
Externí odkaz:
https://doaj.org/article/866b000bd0524b18baec1ef3a47518c6
Autor:
Atieh Hajirahimkhan, Caitlin Howell, Elizabeth T. Bartom, Huali Dong, Daniel D. Lantvit, Xiaoling Xuei, Shao-Nong Chen, Guido F. Pauli, Judy L. Bolton, Susan E. Clare, Seema A. Khan, Birgit M. Dietz
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Breast cancer risk continues to increase post menopause. Anti-estrogen therapies are available to prevent postmenopausal breast cancer in high-risk women. However, their adverse effects have reduced acceptability and overall success in cance
Externí odkaz:
https://doaj.org/article/b8f59066aa7a47d7acf8ab8b42dc1051
Autor:
York E. Miller, Moumita Ghosh, Daniel T. Merrick, Brandi Kubala, Eva Szabo, Lisa Bengtson, Masha Kocherginsky, Irene B. Helenowski, Kelly Benante, Tia Schering, Jihye Kim, Hyunmin Kim, Duc Ha, Raymond C. Bergan, Seema A. Khan, Robert L. Keith
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionIloprost, a prostacyclin analog, has lung cancerpreventive activity in preclinical models and improved dysplasia in former smokers in a phase IIb trial. Oral iloprost is currently unavailable. We performed a phase Ib trial of inhaled ilop
Externí odkaz:
https://doaj.org/article/502903e34d9c4e43b8cf25ff8ca2f407
Autor:
Oukseub Lee, Minhua Wang, Omid Hosseini, Maarten C. Bosland, Miguel Muzzio, Irene Helenowski, Seema A. Khan
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 162, Iss , Pp 114607- (2023)
Aggressive estrogen receptor (ER) positive breast cancer is frequently tamoxifen-resistant; alternative endocrine approaches exist for therapy, but not for prevention, particularly in premenopausal women. We examined the efficacy of the selective ER
Externí odkaz:
https://doaj.org/article/8344c8c8d0934f1d8bb111c6691ef418
Autor:
Shivangi Yadav, Ranya Virk, Carolina H. Chung, Mariana Bustamante Eduardo, David VanDerway, Duojiao Chen, Kirsten Burdett, Hongyu Gao, Zexian Zeng, Manish Ranjan, Gannon Cottone, Xiaoling Xuei, Sriram Chandrasekaran, Vadim Backman, Robert Chatterton, Seema Ahsan Khan, Susan E. Clare
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-17 (2022)
Abstract Improved understanding of local breast biology that favors the development of estrogen receptor negative (ER−) breast cancer (BC) would foster better prevention strategies. We have previously shown that overexpression of specific lipid met
Externí odkaz:
https://doaj.org/article/52f370b4b3ad414294bef582910b2c61
Autor:
Zexian Zeng, Chengsheng Mao, Andy Vo, Xiaoyu Li, Janna Ore Nugent, Seema A. Khan, Susan E. Clare, Yuan Luo
Publikováno v:
BMC Bioinformatics, Vol 22, Iss S4, Pp 1-13 (2021)
Abstract Background Genetic information is becoming more readily available and is increasingly being used to predict patient cancer types as well as their subtypes. Most classification methods thus far utilize somatic mutations as independent feature
Externí odkaz:
https://doaj.org/article/039ab7f7844f490e8b53a1ab45ad0851
Autor:
Manish Ranjan, Oukseub Lee, Gannon Cottone, Elnaz Mirzaei Mehrabad, Benjamin T. Spike, Zexian Zeng, Shivangi Yadav, Robert Chatterton, J. Julie Kim, Susan E. Clare, Seema A. Khan
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-17 (2021)
Abstract Background The ovarian hormones estrogen and progesterone (EP) are implicated in breast cancer causation. A specific consequence of progesterone exposure is the expansion of the mammary stem cell (MSC) and luminal progenitor (LP) compartment
Externí odkaz:
https://doaj.org/article/54ebd66fced14276b1e7e69565c3d521
Autor:
Shivangi Yadav, Ranya Virk, Carolina H. Chung, Mariana Bustamante Eduardo, David VanDerway, Duojiao Chen, Kirsten Burdett, Hongyu Gao, Zexian Zeng, Manish Ranjan, Gannon Cottone, Xiaoling Xuei, Sriram Chandrasekaran, Vadim Backman, Robert Chatterton, Seema Ahsan Khan, Susan E. Clare
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/0482c004ab534c9386ad84675aab7af9
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-13 (2019)
Abstract Background Women, who carry a germline BRCA1 gene mutation, have a markedly increased risk of developing breast cancer during their lifetime. While BRCA1 carriers frequently develop triple-negative, basal-like, aggressive breast tumors, horm
Externí odkaz:
https://doaj.org/article/c35c8f44df574135a6c1f38e19325c74