Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Seema, Chugh"'
Autor:
Sunita Shankar, Jean Ching-Yi Tien, Ronald F. Siebenaler, Seema Chugh, Vijaya L. Dommeti, Sylvia Zelenka-Wang, Xiao-Ming Wang, Ingrid J. Apel, Jessica Waninger, Sanjana Eyunni, Alice Xu, Malay Mody, Andrew Goodrum, Yuping Zhang, John J. Tesmer, Rahul Mannan, Xuhong Cao, Pankaj Vats, Sethuramasundaram Pitchiaya, Stephanie J. Ellison, Jiaqi Shi, Chandan Kumar-Sinha, Howard C. Crawford, Arul M. Chinnaiyan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Argonaute 2 (AGO2) binds RAS and is required for cellular transformation. Here, the authors establish a KRAS-driven mouse model of pancreatic cancer with conditional loss of AGO2 and show that the early phase of neoplastic lesion initiation is depend
Externí odkaz:
https://doaj.org/article/4879439f815846169a9d5e62cae6d7c2
Autor:
Srikanth Barkeer, Seema Chugh, Saswati Karmakar, Garima Kaushik, Sanchita Rauth, Satyanarayana Rachagani, Surinder K. Batra, Moorthy P. Ponnusamy
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-15 (2018)
Abstract Background Glycosylation plays a critical role in the aggressiveness of pancreatic cancer (PC). Emerging evidences indicate significant involvement of cancer stem cells (CSCs) in PC aggressiveness. However, the importance of glycosylation in
Externí odkaz:
https://doaj.org/article/70214dd4c5ac4e30a1cde8d00b179290
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 8, Pp 813-825 (2018)
Aberrant glycosylation plays a critical role in tumor aggressiveness, progression, and metastasis. Emerging evidence associates cancer initiation and metastasis to the enrichment of cancer stem cells (CSCs). Several universal markers have been identi
Externí odkaz:
https://doaj.org/article/253199de21454c809382681013622070
Autor:
Seema Chugh, Rama Krishna Nimmakayala, Christopher M. Thompson, Sushil Kumar, Satyanarayana Rachagani, Frank Leon, Moorthy P. Ponnusamy, Saswati Karmakar, Palanisamy Nallasamy, Rohitesh Gupta, Dipakkumar R. Prajapati
Publikováno v:
British Journal of Cancer
Br J Cancer
Br J Cancer
Background Several reports have shown the role of glycosylation in pancreatic cancer (PC), but a global systematic screening of specific glycosyltransferases (glycoTs) in its progression remains unknown. Methods We demonstrate a rigorous top-down app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4991c12cb93fa4518d02a1e1ec7e381d
http://europepmc.org/articles/PMC7251111
http://europepmc.org/articles/PMC7251111
Autor:
Ronald F, Siebenaler, Seema, Chugh, Jessica J, Waninger, Vijaya L, Dommeti, Carson, Kenum, Malay, Mody, Anudeeta, Gautam, Nidhi, Patel, Alec, Chu, Pushpinder, Bawa, Jennifer, Hon, Richard D, Smith, Heather, Carlson, Xuhong, Cao, John J G, Tesmer, Sunita, Shankar, Arul M, Chinnaiyan
Publikováno v:
PNAS nexus. 1(3)
Activating mutations in RAS GTPases drive nearly 30% of all human cancers. Our prior work described an essential role for Argonaute 2 (AGO2), of the RNA-induced silencing complex, in mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a0db7859f58a658fbd6a0c12517a0b0
https://pubmed.ncbi.nlm.nih.gov/35923912
https://pubmed.ncbi.nlm.nih.gov/35923912
Autor:
Yize Li, Tung-Shing M. Lih, Saravana M. Dhanasekaran, Rahul Mannan, Lijun Chen, Marcin Cieslik, Yige Wu, Rita Jiu-Hsien Lu, David J. Clark, Iga Kołodziejczak, Runyu Hong, Siqi Chen, Yanyan Zhao, Seema Chugh, Wagma Caravan, Nataly Naser Al Deen, Noshad Hosseini, Chelsea J. Newton, Karsten Krug, Yuanwei Xu, Kyung-Cho Cho, Yingwei Hu, Yuping Zhang, Chandan Kumar-Sinha, Weiping Ma, Anna Calinawan, Matthew A. Wyczalkowski, Michael C. Wendl, Yuefan Wang, Shenghao Guo, Cissy Zhang, Anne Le, Aniket Dagar, Alex Hopkins, Hanbyul Cho, Felipe da Veiga Leprevost, Xiaojun Jing, Guo Ci Teo, Wenke Liu, Melissa A. Reimers, Russell Pachynski, Alexander J. Lazar, Arul M. Chinnaiyan, Brian A. Van Tine, Bing Zhang, Karin D. Rodland, Gad Getz, D.R. Mani, Pei Wang, Feng Chen, Galen Hostetter, Mathangi Thiagarajan, W. Marston Linehan, David Fenyö, Scott D. Jewell, Gilbert S. Omenn, Rohit Mehra, Maciej Wiznerowicz, Ana I. Robles, Mehdi Mesri, Tara Hiltke, Eunkyung An, Henry Rodriguez, Daniel W. Chan, Christopher J. Ricketts, Alexey I. Nesvizhskii, Hui Zhang, Li Ding, Alicia Francis, Amanda G. Paulovich, Andrzej Antczak, Anthony Green, Antonio Colaprico, Ari Hakimi, Barb Pruetz, Barbara Hindenach, Birendra Kumar Yadav, Boris Reva, Brenda Fevrier-Sullivan, Brian J. Druker, Cezary Szczylik, Charles A. Goldthwaite, Chet Birger, Corbin D. Jones, Daniel C. Rohrer, Darlene Tansil, David Chesla, David Heiman, Elizabeth Duffy, Eri E. Schadt, Francesca Petralia, Gabriel Bromiński, Gabriela M. Quiroga-Garza, George D. Wilson, Ginny Xiaohe Li, Grace Zhao, Yi Hsiao, James Hsieh, Jan Lubiński, Jasmin Bavarva, Jasmine Huang, Jason Hafron, Jennifer Eschbacher, Jennifer Hon, Jesse Francis, John Freymann, Josh Vo, Joshua Wang, Justin Kirby, Kakhaber Zaalishvili, Karen A. Ketchum, Katherine A. Hoadley, Ki Sung Um, Liqun Qi, Marcin J. Domagalski, Matt Tobin, Maureen Dyer, Meenakshi Anurag, Melissa Borucki, Michael A. Gillette, Michael J. Birrer, Michael M. Ittmann, Michael H. Roehrl, Michael Schnaubelt, Michael Smith, Mina Fam, Nancy Roche, Negin Vatanian, Nicollette Maunganidze, Olga Potapova, Oxana V. Paklina, Pamela VanderKolk, Patricia Castro, Paweł Kurzawa, Pushpa Hariharan, Qin Li, Qing Kay Li, Rajiv Dhir, Ratna R. Thangudu, Rebecca Montgomery, Richard D. Smith, Sailaja Mareedu, Samuel H. Payne, Sandra Cerda, Sandra Cottingham, Sarah Haynes, Shankha Satpathy, Shannon Richey, Shilpi Singh, Shirley X. Tsang, Shuang Cai, Song Cao, Stacey Gabriel, Steven A. Carr, Tao Liu, Thomas Bauer, Toan Le, Xi S. Chen, Xu Zhang, Yvonne Shutack, Zhen Zhang
Publikováno v:
Cancer Cell. 41:139-163.e17
Clear cell renal cell carcinomas (ccRCCs) represent ∼75% of RCC cases and account for most RCC-associated deaths. Inter- and intratumoral heterogeneity (ITH) results in varying prognosis and treatment outcomes. To obtain the most comprehensive prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4878f21a9513cdfa5b273d1fdbaef4e6
https://doi.org/10.1016/j.ccell.2022.12.001
https://doi.org/10.1016/j.ccell.2022.12.001
Autor:
Rama K. Nimmakayala, Raghupathy Vengoji, Jesse L. Cox, Frank Leon, Moorthy P. Ponnusamy, Palanisamy Nallasamy, Seema Chugh, Satyanarayana Rachagani, Surinder K. Batra, Kavita Mallya, Saswati Karmakar, Parthasarathy Seshacharyulu
Publikováno v:
Oncogene. 41(1)
Aberrant protein glycosylation has been shown to have a significant contribution in aggressive cancer, including pancreatic cancer (PC). Emerging evidence has implicated the involvement of cancer stem cells (CSCs) in PC aggressiveness; however, the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde0af0be8197c0bc1a1905b0ee6824c
https://pubmed.ncbi.nlm.nih.gov/34675409
https://pubmed.ncbi.nlm.nih.gov/34675409
Autor:
Rui Wang, Fengyun Su, Alice Xu, Arul M. Chinnaiyan, Yunhui Cheng, Sunita Shankar, Jennifer Hon, Lisha Wang, Rahul Mannan, Jean Ching-Yi Tien, Andrew Goodrum, Vijaya L. Dommeti, Seema Chugh, Xuhong Cao, Xiaoming Wang, Carson Kenum, Yuping Zhang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance RAS proteins (HRAS, NRAS, and KRAS) integrate extracellular trophic signals to promote cell proliferation. Constitutively active KRAS drives tumor initiation and progression in nonsmall cell lung cancer (NSCLC). As RAS proteins are often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70602fef14a9fbd0647e8f5b232338b9
https://pubmed.ncbi.nlm.nih.gov/33972443
https://pubmed.ncbi.nlm.nih.gov/33972443
Autor:
Seema Chugh, Jean C. Tien, Jennifer Hon, Pushpinder Singh Bawa, Carson Kenum, Chi Chiang Li, Yunhui Cheng, Andrew D. Delekta, Jae Eun Choi, Rahul Mannan, Yuanyuan Qiao, Rajen Mody, Arul Chinnaiyan
Publikováno v:
Cancer Research. 82:2018-2018
Neuroblastoma (NB) is the most common extracranial pediatric tumor, and accounts for approximately 12% of cancer-related deaths in children. Though several genomic drivers have been identified, the development of targeted therapy for treating this ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e98ef31f83c29246aea5718aa1eb40af
https://doi.org/10.1158/1538-7445.am2022-2018
https://doi.org/10.1158/1538-7445.am2022-2018
Autor:
Jennifer Hon, Carson Kenum, Pushpinder S. Bawa, Vijaya L. Dommeti, Anastasia A. Sahu, Miriam Gandham, Chi-Chiang Li, Zainab I. Taher, Sylvia Zelenka-Wang, Jean C. Tien, Sunita Shankar, Seema Chugh, Arul M. Chinnaiyan
Publikováno v:
Cancer Research. 82:2538-2538
KRAS mutations have been observed in nearly 95% of pancreatic ductal adenocarcinoma (PDAC), however targeting KRAS remains a major therapeutic challenge. Previous studies from our group have discovered a novel interaction between KRAS and Argonaute 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1529d7ae24333c70c5b7f6dd87f6467b
https://doi.org/10.1158/1538-7445.am2022-2538
https://doi.org/10.1158/1538-7445.am2022-2538