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Loss of Heterozygosity at 1p36 Independently Predicts for Disease Progression But Not Decreased Overall Survival Probability in Neuroblastoma Patients: A Children’s Cancer Group Study

Autor: Erik P. Sulman, Peter White, John N. Lukens, Patricia M. Thompson, Michael D. Hogarty, Matthew J. Weiss, Seeger Rc, Katherine K. Matthay, Garrett M. Brodeur, John M. Maris, Daniel O. Stram, Robert B. Gerbing, Chun Guo

Publikováno v: Journal of Clinical Oncology. 18:1888-1899

PURPOSE: To determine the independent prognostic significance of 1p36 loss of heterozygosity (LOH) in a representative group of neuroblastoma patients. PATIENTS AND METHODS: Diagnostic tumor specimens from 238 patients registered onto the most recent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c57277f87dd86cafe98d6e0f700166
https://doi.org/10.1200/jco.2000.18.9.1888

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Treatment of High-Risk Neuroblastoma with Intensive Chemotherapy, Radiotherapy, Autologous Bone Marrow Transplantation, and 13-cis-Retinoic Acid

Autor: Richard E. Harris, Garrett M. Brodeur, Patrick S. Swift, Seeger Rc, Daniel O. Stram, Katherine K. Matthay, C. P. Reynolds, Judith G. Villablanca, H. Shimada, Robert B. Gerbing, C T Black, Norma K.C. Ramsay

Publikováno v: New England Journal of Medicine. 341:1165-1173

Background Children with high-risk neuroblastoma have a poor outcome. In this study, we assessed whether myeloablative therapy in conjunction with transplantation of autologous bone marrow improved event-free survival as compared with chemotherapy al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8515fcf2a0bbe2cb87dbe6659b478256
https://doi.org/10.1056/nejm199910143411601

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Successful treatment of stage III neuroblastoma based on prospective biologic staging: a Children's Cancer Group study

Autor: James B. Atkinson, H. Shimada, Katherine K. Matthay, Robert B. Gerbing, Daniel O. Stram, Gerald M. Haase, C T Black, Seeger Rc, Patrick S. Swift, Carlos A. Perez, John N. Lukens, Garrett M. Brodeur

Publikováno v: Journal of Clinical Oncology. 16:1256-1264

PURPOSE To identify a biologically favorable and unfavorable subset of patients with Evans stage III neuroblastoma and to determine whether treatment stratification would improve the event-free survival (EFS) for high-risk patients and maintain excel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d905d38cf455727b99dc90715026e1
https://doi.org/10.1200/jco.1998.16.4.1256

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Phase I trial of 13-cis-retinoic acid in children with neuroblastoma following bone marrow transplantation

Autor: C. P. Reynolds, Vassilios I. Avramis, Seeger Rc, Judith G. Villablanca, Katherine K. Matthay, A. A. Khan, Norma K.C. Ramsay

Publikováno v: Europe PubMed Central

PURPOSE Treatment of neuroblastoma cell lines with 13-cis-retinoic acid (cis-RA) can cause sustained inhibition of proliferation. Since cis-RA has demonstrated clinical responses in neuroblastoma patients, it may be effective in preventing relapse af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97445966e69c9073cb8ee16a5cff4d1
https://doi.org/10.1200/jco.1995.13.4.894

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Patterns of relapse after autologous purged bone marrow transplantation for neuroblastoma: a Childrens Cancer Group pilot study

Autor: Michael T. Selch, James B. Atkinson, Daniel O. Stram, Katherine K. Matthay, C. P. Reynolds, Seeger Rc

Publikováno v: Europe PubMed Central

PURPOSE The goal of this investigation was to determine if comparing sites of neuroblastoma at relapse after myeloablative chemoradiotherapy and purged autologous bone marrow transplantation (ABMT) with sites of disease at diagnosis and before ABMT c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab7521fa08d389c8e59e34d67dd6480
https://doi.org/10.1200/jco.1993.11.11.2226

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Consensus criteria for sensitive detection of minimal neuroblastoma cells in bone marrow, blood and stem cell preparations by immunocytology and QRT-PCR: recommendations by the International Neuroblastoma Risk Group Task Force

Autor: Beiske, K, Burchill, SA, Cheung, IY, Hiyama, E, Seeger, RC, Cohn, SL, Pearson, ADJ, Matthay, KK, International neuroblastoma Risk Group Task Force

Publikováno v: British journal of cancer, vol 100, iss 10

Disseminating disease is a predictive and prognostic indicator of poor outcome in children with neuroblastoma. Its accurate and sensitive assessment can facilitate optimal treatment decisions. The International Neuroblastoma Risk Group (INRG) Task Fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7e77de3b980f95f9c3cf0148ac7be798
https://escholarship.org/uc/item/4ps6d5j2

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A significant association of Ha-ras p21 in neuroblastoma cells with patient prognosis. A retrospective study of 103 cases

Autor: Takahito Fujisawa, Seeger Rc, Hiroyuki Shimada, Dennis J. Slamon, Takeo Tanaka, Noriaki Ida, Hiroko Shimoda

Publikováno v: Cancer. 68:1296-1302

To evaluate biologic characteristics of neuroblastoma, the authors examined the expression of Ha-ras gene (Ha-ras p21) in 103 primary tumors obtained at the time of diagnosis. Higher expression of the Ha-ras p21 in tumor cells showed a significant as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8128036a24a8dc82ba76404d26ce5435
https://doi.org/10.1002/1097-0142(19910915)68:6<1296::aid-cncr2820680619>3.0.co

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High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification

Autor: F Lottspeich, C P Reynolds, Christoph Eckerskorn, Seeger Rc, John R. Strahler, Nabil Hailat, Xiao-Xiang Zhu, Garrett M. Brodeur, R. Melhem, David R. Keim

The gene encoding a novel protein designated nm23-H1, which was recently identified as identical to the A subunit of nucleotide diphosphate kinase from human erythrocytes, has been proposed to play a role in tumor metastasis suppression. We report th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00b0f484834a641fd7646230b732636
https://europepmc.org/articles/PMC296039/

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Prognostic value of immunocytologic detection of bone marrow metastases in neuroblastoma

Autor: S G Romansky, Seeger Rc, T J Moss, Harland N. Sather, G D Hammond, C. P. Reynolds

Publikováno v: The New England journal of medicine. 324(4)

Morphologic evaluation of bone marrow for neuroblastoma cells is a routine and important component of clinical staging. Specific immunostaining of malignant cells with monoclonal antibodies should be more sensitive, however, and may improve the detec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be8cd7941986e70303bafa312c8ed0c
https://pubmed.ncbi.nlm.nih.gov/1985243

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