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Reply to Ashktorab et al.: Mutational landscape of colon cancers in African Americans.

Autor: Guda K; Division of General Medical Sciences-Oncology, Case Comprehensive Cancer Center, and Department of Medicine., Veigl ML; Case Comprehensive Cancer Center, and Department of Medicine., Varadan V; Division of General Medical Sciences-Oncology, Case Comprehensive Cancer Center, and., Nosrati A; Division of Hematology and Oncology., Ravi L; Division of Hematology and Oncology., Lutterbaugh J; Division of Hematology and Oncology., Beard L; Division of Hematology and Oncology., Willson JK; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390; and., Sedwick WD; Case Comprehensive Cancer Center, and Department of Medicine, Division of Hematology and Oncology., Wang ZJ; Case Comprehensive Cancer Center, and Department of Genetics and Genome Sciences., Molyneaux N; Department of Genetics and Genome Sciences., Miron A; Department of Genetics and Genome Sciences., Adams MD; J. Craig Venter Institute, La Jolla, CA 92037., Elston RC; Case Comprehensive Cancer Center, and Department of Epidemiology and Biostatistics., Markowitz SD; Case Comprehensive Cancer Center, and Department of Medicine, Division of Hematology and Oncology, Case Medical Center, Case Western Reserve University, Cleveland, OH 44106; sxm10@case.edu., Willis JE; Case Comprehensive Cancer Center, and Department of Medicine, Case Medical Center, Case Western Reserve University, Cleveland, OH 44106; Department of Pathology.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Jun 02; Vol. 112 (22), pp. E2853. Date of Electronic Publication: 2015 May 04.

Antifolate-induced misincorporation of deoxyuridine monophosphate into DNA: inhibition of high molecular weight DNA synthesis in human lymphoblastoid cells

Autor: Oliver E. Brown, Sedwick Wd, Marc Kutler

Publikováno v: Proceedings of the National Academy of Sciences. 78:917-921

In vitro exposure of a human lymphoblastoid cell line (WIL-2) to the antifolate metoprine (DDMP), when followed by the addition of exogenous deoxyuridine, led to intracellular accumulation of deoxyuridine triphosphate (dUTP) and incorporation of deox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985af1a8ab932c75ecf8ad6fa2af3dc0
https://doi.org/10.1073/pnas.78.2.917