PLK1 overexpression suppresses homologous recombination and confers cellular sensitivity to PARP inhibition.

Autor: Pae S; Department of Frontier Medicine, Institute of Medical Science, Graduate School of Medicine, St. Marianna University, Kawasaki, 2168511, Japan., Sedukhina AS; Department of Frontier Medicine, Institute of Medical Science, Graduate School of Medicine, St. Marianna University, Kawasaki, 2168511, Japan.; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan., Sugiyama R; Department of Breast and Endocrine Surgery, Graduate School of Medicine, St. Marianna University, Kawasaki, 216-8511, Japan., Atanacio SJ; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan., Ohara T; Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kawasaki, 216-8511, Japan., Ishii M; Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kawasaki, 216-8511, Japan., Minagawa K; Division of Genomic Epidemiology and Clinical Trials, Clinical Trials Research Center, Nihon University School of Medicine, Tokyo, Japan., Akichjev R; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan.; Katholieke Universiteit Leuven, 3000, Leuven, Belgium., Go F; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan.; K International School Tokyo, Koto, 1350021, Japan., Chandankeri Z; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan.; K International School Tokyo, Koto, 1350021, Japan., Janjetic ZMM; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan.; K International School Tokyo, Koto, 1350021, Japan., Sato E; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan., Yamaura A; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan., Meguro R; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan.; University of Michigan Ann Arbor, Ann Arbor, MI, 48109, USA., Palanisamy K; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan.; School of Medicine, University of Nottingham, Nottingham, NG7 2UH, UK., Maeda I; Department of Pathology, Kitasato University Kitasato Institute Hospital, Minato, 1080072, Japan.; Department of Pathology, Kitasato University School of Medicine, Sagamihara, 2520374, Japan., Takeuchi O; Biomedical Laboratory, Department of Research, Kitasato University Kitasato Institute Hospital, Tokyo, Japan., Suzuki N; Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kawasaki, 216-8511, Japan., Yudo K; Department of Frontier Medicine, Institute of Medical Science, Graduate School of Medicine, St. Marianna University, Kawasaki, 2168511, Japan., Bernal JA; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Sato K; Department of Frontier Medicine, Institute of Medical Science, Graduate School of Medicine, St. Marianna University, Kawasaki, 2168511, Japan. kosato@marianna-u.ac.jp.; Shirokane Sanko Clinic Research Centre, Minato, 1080072, Japan. kosato@marianna-u.ac.jp.

Publikováno v: Scientific reports [Sci Rep] 2024 Dec 28; Vol. 14 (1), pp. 31276. Date of Electronic Publication: 2024 Dec 28.

A new bioinformatics approach identifies overexpression of GRB2 as a poor prognostic biomarker for prostate cancer

Autor: Teppei Iwata, Anna S. Sedukhina, Manabu Kubota, Shigeko Oonuma, Ichiro Maeda, Miki Yoshiike, Wataru Usuba, Kimino Minagawa, Eleina Hames, Rei Meguro, Sunny Cho, Stephen H. H. Chien, Shiro Urabe, Sookhee Pae, Kishore Palanisamy, Toshio Kumai, Kazuo Yudo, Eiji Kikuchi, Ko Sato

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)

Abstract A subset of prostate cancer displays a poor clinical outcome. Therefore, identifying this poor prognostic subset within clinically aggressive groups (defined as a Gleason score (GS) ≧8) and developing effective treatments are essential if

Externí odkaz: https://doaj.org/article/57ba76a682034c09bcdb46e58c83ae0b

A new bioinformatics approach identifies overexpression of GRB2 as a poor prognostic biomarker for prostate cancer.

Autor: Iwata, Teppei^1,2, Sedukhina, Anna S.¹, Kubota, Manabu³, Oonuma, Shigeko³, Maeda, Ichiro^4,5, Yoshiike, Miki², Usuba, Wataru², Minagawa, Kimino⁶, Hames, Eleina⁷, Meguro, Rei⁷, Cho, Sunny⁷, Chien, Stephen H. H.⁷, Urabe, Shiro⁷, Pae, Sookhee⁷, Palanisamy, Kishore⁷, Kumai, Toshio⁶, Yudo, Kazuo¹, Kikuchi, Eiji², Sato, Ko¹ kosato@marianna-u.ac.jp

Publikováno v: Scientific Reports. 3/11/2021, Vol. 11 Issue 1, p1-8. 8p.

NF‐kB signaling in cardiomyocytes is inhibited by sevoflurane and promoted by propofol

Autor: Juan A. Bernal, Miki Sakamoto, Toshio Kumai, Marta Roche-Molina, Anna S. Sedukhina, Ko Sato, Mariya Lytvyn, Eiichi Inada, Eri Sato, Keiko Oda-Kawashima, Ayako Yamaura, Naoki Okamoto, Teppei Iwata, Kimino Minagawa

Publikováno v: FEBS Open Bio
Repisalud
Instituto de Salud Carlos III (ISCIII)
FEBS Open Bio, Vol 10, Iss 2, Pp 259-267 (2020)

Both inhalational and intravenous anesthetics affect myocardial remodeling, but the precise effect of each anesthetic on molecular signaling in myocardial remodeling is unknown. Here, we performed in silico analysis to investigate signaling alteratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4aa5c3adf9bfa2023d56ef09bc2a1e7
http://europepmc.org/articles/PMC6996339

LSD1 Overexpression Is Associated with Poor Prognosis in Basal-Like Breast Cancer, and Sensitivity to PARP Inhibition.

Autor: Nagasawa, Satoi^1,2, Sedukhina, Anna S.¹, Nakagawa, Yuko^1,3, Maeda, Ichiro⁴, Kubota, Manabu⁴, Ohnuma, Shigeko⁴, Tsugawa, Koichiro², Ohta, Tomohiko¹, Roche-Molina, Marta⁵, Bernal, Juan A.⁵, Narváez, Ana J.⁶, Jeyasekharan, Anand D.⁷, Sato, Ko¹ kosato@marianna-u.ac.jp

Publikováno v: PLoS ONE. Feb2015, Vol. 10 Issue 2, p1-12. 12p.