A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis.

Autor: Sedrani C; Luxembourg Centre for Systems Biomedicine, University of Luxembourg., Gomez-Giro G; Luxembourg Centre for Systems Biomedicine, University of Luxembourg., Grandmougin L; Luxembourg Centre for Systems Biomedicine, University of Luxembourg., Schwamborn JC; Luxembourg Centre for Systems Biomedicine, University of Luxembourg., Wilmes P; Luxembourg Centre for Systems Biomedicine, University of Luxembourg; Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine, University of Luxembourg; paul.wilmes@uni.lu.

Publikováno v: Journal of visualized experiments : JoVE [J Vis Exp] 2023 Jul 28 (197). Date of Electronic Publication: 2023 Jul 28.

Design and Characterization of a Novel eEF2K Degrader with Potent Therapeutic Efficacy Against Triple‐Negative Breast Cancer.

Autor: Zhong, Changxin^1,2 (AUTHOR), Zhu, Rongfeng³ (AUTHOR), Jiang, Ting^1,2 (AUTHOR), Tian, Sheng³ (AUTHOR), Zhao, Xiaobao³ (AUTHOR), Wan, Xiaoya^1,2 (AUTHOR), Jiang, Shilong⁴ (AUTHOR), Chen, Zonglin^1,5 (AUTHOR), Gong, Rong^1,2 (AUTHOR), He, Linhao^1,2 (AUTHOR), Yang, Jin‐Ming⁶ (AUTHOR), Ye, Na³ (AUTHOR) yena@suda.edu.cn, Cheng, Yan^1,2,7 (AUTHOR) yancheng@csu.edu.cn

Publikováno v: Advanced Science. 2/2/2024, Vol. 11 Issue 5, p1-16. 16p.

Strategies for Competitive Activity‐Based Protein Profiling in Small Molecule Inhibitor Discovery and Characterization.

Autor: Zhu, He^1,2,3 (AUTHOR), Sharafi, Mona^1,4 (AUTHOR), Teh, Wei Pin^1,4 (AUTHOR), Bratt, Ariana S.^1,4 (AUTHOR), Buhrlage, Sara J.^1,4,5 (AUTHOR), Marto, Jarrod A.^1,2,3,5 (AUTHOR) Jarrod_Marto@dfci.harvard.edu

Publikováno v: Israel Journal of Chemistry. Mar2023, Vol. 63 Issue 3/4, p1-13. 13p.

We are MedChem: The Frontiers in Medicinal Chemistry 2024.

Autor: Schiedel M; Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106, Braunschweig, Germany., Barbie P; Bayer AG, R&D, Pharmaceuticals Laboratory IV, Bldg., S106, 231, 13342, Berlin, Germany., Pape F; NUVISAN GmbH, Muellerstraße 178, 13353, Berlin, Germany., Pinto M; AbbVie Deutschland GmbH & Co. KG Computational Drug Discovery, Knollstrasse, 67061, Ludwigshafen, Germany., Unzue Lopez A; Merck Healthcare KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany., Méndez M; Sanofi R&D, Integrated Drug Discovery Industriepark Höchst, Bldg. G838, 65926, Frankfurt am Main, Germany., Hessler G; Sanofi R&D, Integrated Drug Discovery Industriepark Höchst, Bldg. G838, 65926, Frankfurt am Main, Germany., Merk D; Department of Pharmacy, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377, Munich, Germany., Gehringer M; Institute for Biomedical Engineering, Faculty of Medicine, University of Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany.; Institute of Pharmaceutical Sciences, Pharmaceutical/Medicinal Chemistry Department, University of Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany., Lamers C; Institute of Drug Discovery, Faculty of Medicine, Leipzig University, Brüderstr. 34, 04103, Leipzig, Germany.

Publikováno v: ChemMedChem [ChemMedChem] 2024 Sep 23, pp. e202400543. Date of Electronic Publication: 2024 Sep 23.

Searching for Small Molecules with an Atomic Sort.

Autor: Duggan, Brendan M.¹ (AUTHOR) bmduggan@ucsd.edu, Cullum, Reiko² (AUTHOR), Fenical, William² (AUTHOR), Amador, Luis A.³ (AUTHOR), Rodríguez, Abimael D.³ (AUTHOR), La Clair, James J.⁴ (AUTHOR) jlaclair@ucsd.edu

Publikováno v: Angewandte Chemie. Jan2020, Vol. 132 Issue 3, p1160-1164. 5p.