Adeno-associated virus-mediated gene delivery of Perm1 enhances cardiac contractility in mice.

Autor: Sreedevi K; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.; Center for Vascular and Heart Research, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia, United States., Zaitsev AV; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.; Center for Vascular and Heart Research, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia, United States., Doku A; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.; Translational Biology Medicine and Health Graduate Program, Virginia Tech, Blacksburg, Virginia, United States.; Center for Vascular and Heart Research, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia, United States., Thomas R; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.; Translational Biology Medicine and Health Graduate Program, Virginia Tech, Blacksburg, Virginia, United States.; Center for Vascular and Heart Research, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia, United States., James A; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.; Department of Human Nutrition, Food and Exercise, Virginia Tech, Blacksburg, Virginia, United States.; Center for Vascular and Heart Research, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia, United States., Do S; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.; Center for Vascular and Heart Research, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia, United States., Zhang M; Fralin Biomedical Research Institute, Center for Exercise Medicine Research at Virginia Tech Carilion, Roanoke, Virginia, United States., Sedovy MW; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.; Translational Biology Medicine and Health Graduate Program, Virginia Tech, Blacksburg, Virginia, United States.; Center for Vascular and Heart Research, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia, United States., Leng X; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.; Center for Vascular and Heart Research, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia, United States., Dennison CL; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.; Center for Vascular and Heart Research, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia, United States.; Tissue Processing Core at Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia, United States., Johnstone SR; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.; Center for Vascular and Heart Research, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia, United States.; Department of Biological Sciences, College of Science, Virginia Tech, Roanoke, Virginia, United States.; Department of Surgery, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, United States., Kirk JA; Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois, United States., Yan Z; Department of Human Nutrition, Food and Exercise, Virginia Tech, Blacksburg, Virginia, United States.; Fralin Biomedical Research Institute, Center for Exercise Medicine Research at Virginia Tech Carilion, Roanoke, Virginia, United States., Warren JS; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, Virginia, United States.; Department of Human Nutrition, Food and Exercise, Virginia Tech, Blacksburg, Virginia, United States.; Center for Vascular and Heart Research, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia, United States.

Publikováno v: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2024 Oct 01; Vol. 327 (4), pp. H1112-H1118. Date of Electronic Publication: 2024 Sep 13.

Preserving Endothelial Integrity in Human Saphenous Veins during Preparation for Coronary Bypass Surgery.

Autor: Sedovy MW; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, Roanoke, Virginia, USA.; Translational Biology, Medicine, and Health Graduate Program, Virginia Tech, Blacksburg, Virginia, USA., Leng X; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, Roanoke, Virginia, USA., Iqbal F; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, Roanoke, Virginia, USA.; Division of Cardiothoracic Surgery, Department of Surgery, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA., Renton MC; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, Roanoke, Virginia, USA., Leaf M; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, Roanoke, Virginia, USA.; Division of Cardiothoracic Surgery, Department of Surgery, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA., Roberts K; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, Roanoke, Virginia, USA., Malek A; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, Roanoke, Virginia, USA., Arnold WS; Division of Cardiothoracic Surgery, Department of Surgery, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA.; Carilion Cardiothoracic Surgery, Cardiovascular Institute, Carilion Clinic, Roanoke, Virginia, USA., Wyatt DA; Division of Cardiothoracic Surgery, Department of Surgery, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA.; Carilion Cardiothoracic Surgery, Cardiovascular Institute, Carilion Clinic, Roanoke, Virginia, USA., Choate CW; Division of Cardiothoracic Surgery, Department of Surgery, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA.; Carilion Cardiothoracic Surgery, Cardiovascular Institute, Carilion Clinic, Roanoke, Virginia, USA., Rowe JF; Division of Cardiothoracic Surgery, Department of Surgery, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA.; Carilion Cardiothoracic Surgery, Cardiovascular Institute, Carilion Clinic, Roanoke, Virginia, USA., Baker JW; Division of Cardiothoracic Surgery, Department of Surgery, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA.; Carilion Cardiothoracic Surgery, Cardiovascular Institute, Carilion Clinic, Roanoke, Virginia, USA., Johnstone SR; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, Roanoke, Virginia, USA.; Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, USA., Joseph M; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, Roanoke, Virginia, USA.; Division of Cardiothoracic Surgery, Department of Surgery, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA.; Carilion Cardiothoracic Surgery, Cardiovascular Institute, Carilion Clinic, Roanoke, Virginia, USA.

Publikováno v: Journal of vascular research [J Vasc Res] 2024; Vol. 61 (2), pp. 68-76. Date of Electronic Publication: 2024 Jan 12.

A Soluble Platelet-Derived Growth Factor Receptor-β Originates via Pre-mRNA Splicing in the Healthy Brain and Is Upregulated during Hypoxia and Aging.

Autor: Payne LB; Fralin Biomedical Research Institute (FBRI) at Virginia Tech-Carilion (VTC), Roanoke, VA 24016, USA.; FBRI Center for Vascular and Heart Research, Roanoke, VA 24016, USA., Abdelazim H; Fralin Biomedical Research Institute (FBRI) at Virginia Tech-Carilion (VTC), Roanoke, VA 24016, USA.; FBRI Center for Vascular and Heart Research, Roanoke, VA 24016, USA., Hoque M; Fralin Biomedical Research Institute (FBRI) at Virginia Tech-Carilion (VTC), Roanoke, VA 24016, USA.; FBRI Center for Vascular and Heart Research, Roanoke, VA 24016, USA., Barnes A; Fralin Biomedical Research Institute (FBRI) at Virginia Tech-Carilion (VTC), Roanoke, VA 24016, USA.; FBRI Center for Vascular and Heart Research, Roanoke, VA 24016, USA.; Department of Biomedical Engineering and Mechanics, School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061, USA., Mironovova Z; Fralin Biomedical Research Institute (FBRI) at Virginia Tech-Carilion (VTC), Roanoke, VA 24016, USA.; FBRI Center for Vascular and Heart Research, Roanoke, VA 24016, USA., Willi CE; Fralin Biomedical Research Institute (FBRI) at Virginia Tech-Carilion (VTC), Roanoke, VA 24016, USA.; FBRI Center for Vascular and Heart Research, Roanoke, VA 24016, USA., Darden J; Fralin Biomedical Research Institute (FBRI) at Virginia Tech-Carilion (VTC), Roanoke, VA 24016, USA.; FBRI Center for Vascular and Heart Research, Roanoke, VA 24016, USA., Houk C; Fralin Biomedical Research Institute (FBRI) at Virginia Tech-Carilion (VTC), Roanoke, VA 24016, USA.; Virginia Tech Carilion School of Medicine, Roanoke, VA 24016, USA., Sedovy MW; Fralin Biomedical Research Institute (FBRI) at Virginia Tech-Carilion (VTC), Roanoke, VA 24016, USA.; FBRI Center for Vascular and Heart Research, Roanoke, VA 24016, USA., Johnstone SR; Fralin Biomedical Research Institute (FBRI) at Virginia Tech-Carilion (VTC), Roanoke, VA 24016, USA.; FBRI Center for Vascular and Heart Research, Roanoke, VA 24016, USA.; Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA., Chappell JC; Fralin Biomedical Research Institute (FBRI) at Virginia Tech-Carilion (VTC), Roanoke, VA 24016, USA.; FBRI Center for Vascular and Heart Research, Roanoke, VA 24016, USA.; Department of Biomedical Engineering and Mechanics, School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061, USA.; Virginia Tech Carilion School of Medicine, Roanoke, VA 24016, USA.

Publikováno v: Biomolecules [Biomolecules] 2023 Apr 21; Vol. 13 (4). Date of Electronic Publication: 2023 Apr 21.

Connexin 43 across the Vasculature: Gap Junctions and Beyond.

Autor: Sedovy MW; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, 4 Riverside Circle, Roanoke, Virginia, USA.; Translational Biology, Medicine, And Health Graduate Program, Virginia Tech, Blacksburg, Virginia, USA., Leng X; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, 4 Riverside Circle, Roanoke, Virginia, USA., Leaf MR; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, 4 Riverside Circle, Roanoke, Virginia, USA.; Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA., Iqbal F; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, 4 Riverside Circle, Roanoke, Virginia, USA.; Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA., Payne LB; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, 4 Riverside Circle, Roanoke, Virginia, USA., Chappell JC; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, 4 Riverside Circle, Roanoke, Virginia, USA., Johnstone SR; The Fralin Biomedical Research Institute at Virginia Tech Carilion, Center for Vascular and Heart Research, 4 Riverside Circle, Roanoke, Virginia, USA.; Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, USA.

Publikováno v: Journal of vascular research [J Vasc Res] 2023; Vol. 60 (2), pp. 101-113. Date of Electronic Publication: 2022 Dec 13.

Clinical Impact of Connexin 43 Deregulation on Myocardial Infraction.

Autor: TSANTOULAS, Alexandros¹ alextsantoulas@gmail.com, TSIAMBAS, Evangelos^2,3,4, SPYROPOULOU, Despoina⁵, ADAMOPOULOU, Maria⁶, MASTRONIKOLI, Sofianiki⁷, ROUKAS, Dimitrios⁸, VYLLIOTIS, Antonis⁴, KAFKAS, Nikolaos¹, FOTIADES, Panagiotis³, AGROGIANNIS, George⁸, LAZARIS, Andreas⁸, KAVANTZAS, Nikolaos⁸

Publikováno v: Maedica - a Journal of Clinical Medicine. 2024, Vol. 19 Issue 2, p373-379. 7p.