The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.

Autor: Manry J; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France., Bastard P; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065., Gervais A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France., Le Voyer T; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France., Rosain J; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France., Philippot Q; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France., Michailidis E; Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10065., Hoffmann HH; Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10065., Eto S; Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan., Garcia-Prat M; Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain., Bizien L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France., Parra-Martínez A; Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain., Yang R; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065., Haljasmägi L; Institute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, Estonia., Migaud M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France., Särekannu K; Institute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, Estonia., Maslovskaja J; Institute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, Estonia., de Prost N; Service de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, 94010 Créteil, France.; Groupe de Recherche Clinique Cardiovascular and Respiratory Manifestations of Acute Lung Injury and Sepsis (CARMAS), Faculté de santé de Créteil, Université Paris Est Créteil, 94010 Créteil Cedex, France., Tandjaoui-Lambiotte Y; Hypoxia and Lung, INSERM U1272, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, 93022 Bobigny, France., Luyt CE; Sorbonne Université, Hôpital Pitié Salpêtrière, Médecine Intensive Réanimation, Assistance Publique-Hôpitaux de Paris, 75013 Paris, France.; INSERM, UMRS 1166-iCAN, Institute of Cardiometabolism and Nutrition, 75013 Paris, France., Amador-Borrero B; Internal Medicine Department, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris, 75010 Paris, France., Gaudet A; INSERM U1019-CNRS UMR9017, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, University of Lille, 59000 Lille, France.; Centre Hospitalier Universitaire, de Lille, Pôle de Réanimation, Hôpital Roger Salengro Lille, 59000 Lille, France., Poissy J; INSERM U1019-CNRS UMR9017, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, University of Lille, 59000 Lille, France.; Centre Hospitalier Universitaire, de Lille, Pôle de Réanimation, Hôpital Roger Salengro Lille, 59000 Lille, France., Morel P; Etablissement Français du Sang, 93218 La Plaine Saint-Denis, France.; Interactions Hôte-Greffon-Tumeur et Ingénierie Cellulaire et Génique (RIGHT), INSERM, Etablissement Français du Sang, Université de Franche-Comté, 25000 Besançon, France., Richard P; Etablissement Français du Sang, 93218 La Plaine Saint-Denis, France., Cognasse F; Santé Ingéniérie Biologie St-Etienne (SAINBIOSE), INSERM U1059, University of Lyon, Université Jean Monnet Saint-Etienne, 42000 Saint-Étienne, France.; Etablissement Français du Sang, Auvergne-Rhône-Alpes, 42000 Saint-Étienne, France., Troya J; Department of Internal Medicine, Infanta Leonor University Hospital, 28031 Madrid, Spain., Trouillet-Assant S; Hospices Civils de Lyon, 69002 Lyon, France.; International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, Ecole Nationale Supérieure, Université Claude Bernard Lyon 1 (UCBL), 69365 Lyon, France.; Joint Research Unit, Hospices Civils de Lyon-BioMérieux, Hospices Civils de Lyon, Lyon Sud Hospital, 69495 Pierre-Bénite, France., Belot A; Hospices Civils de Lyon, 69002 Lyon, France.; International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, Ecole Nationale Supérieure, Université Claude Bernard Lyon 1 (UCBL), 69365 Lyon, France.; National Referee Centre for Rheumatic, and Autoimmune and Systemic Diseases in Children, 69000 Lyon, France.; Immunopathology Federation Lyon Immunopathology Federation (LIFE), Hospices Civils de Lyon, 69002 Lyon, France., Saker K; Hospices Civils de Lyon, 69002 Lyon, France.; International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, Ecole Nationale Supérieure, Université Claude Bernard Lyon 1 (UCBL), 69365 Lyon, France., Garçon P; Intensive Care Unit, Grand Hôpital de l'Est Francilien Site de Marne-La-Vallée, 77600 Jossigny, France., Rivière JG; Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain., Lagier JC; Microbes, Evolution, Phylogénie et Infection (MEPHI), Institut Hospitalo-Universitaire Méditerranée Infection, Institut de Recherche pour le Développement, Assistance Publique Hôpitaux de Marseille, Aix-Marseille Université, 13005 Marseille, France., Gentile S; Service d'Evaluation Médicale, Hôpitaux Universitaires de Marseille Assistance Publique Hôpitaux de Marseille, 13005 Marseille, France.; Aix-Marseille University, School of Medicine, EA 3279, Centre d'Études et de Recherche sur les Services de Santé et la Qualité de vie (CEReSS)-Health Service Research and Quality of Life Center, 13385 Marseille, France., Rosen LB; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892., Shaw E; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892., Morio T; Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan., Tanaka J; Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan., Dalmau D; Hospital Universitari MútuaTerrassa, Universitat de Barcelona, 08193 Barcelona, Spain.; Fundació Docència i Recerca Mutua Terrassa, 08221 Terrassa, Spain., Tharaux PL; Paris Cardiovascular Research Center (PARCC), INSERM, Université de Paris, 75015 Paris, France., Sene D; Internal Medicine Department, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris, 75010 Paris, France., Stepanian A; Service d'Hématologie Biologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Université de Paris, 75010 Paris, France.; EA3518, Institut Universitaire d'Hématologie-Hôpital Saint Louis, Université de Paris, 75010 Paris, France., Mégarbane B; Réanimation Médicale et Toxicologique, Hôpital Lariboisière Assistance Publique-Hôpitaux de Paris, Université de Paris, INSERM, UMRS-1144, 75010 Paris, France., Triantafyllia V; Laboratory of Immunobiology, Center for Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece., Fekkar A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Service de Parasitologie-Mycologie, Groupe Hospitalier Pitié Salpêtrière, Assistance Publique-Hôpitaux de Paris, 75013 Paris, France., Heath JR; Institute for Systems Biology, Seattle, WA 98109., Franco JL; Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia UdeA, 050010 Medellín, Colombia., Anaya JM; Center for Autoimmune Disease Research, School of Medicine and Health Sciences, Universidad del Rosario, 110111 Bogotá, Colombia., Solé-Violán J; Intensive Care Medicine, University Hospital of Gran Canaria Dr. Negrín, Canarian Health System, 35010 Las Palmas de Gran Canaria, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain.; Department of Clinical Sciences, Universidad Fernando Pessoa Canarias, 35450 Las Palmas de Gran Canaria, Spain., Imberti L; CHemato-oncology Research Laboratory of Associazione italiana contro le leucemie-linfomi e mieloma, Diagnostic Departement, Azienda Socio Sanitaria Territoriale, Spedali Civili di Brescia, 25123 Brescia, Italy., Biondi A; Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, European Reference Network for Rare Hereditary Metabolic Disorders (MetabERN), University of Milano Bicocca, Fondazione Monza Brianza Bambino Mamma (MBBM), Ospedale San Gerardo, 20900 Monza, Italy., Bonfanti P; Department of Infectious Diseases, San Gerardo Hospital, University of Milano Bicocca, 20900 Monza, Italy., Castagnoli R; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892.; Pediatric Clinic, Fondazione Istituto di Ricovero e Cura a carattere scientifico (IRCCS) Policlinico San Matteo, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy., Delmonte OM; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892., Zhang Y; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892.; National Institute of Allergy and Infectious Diseases (NIAID) Clinical Genomics Program, NIH, Bethesda, MD 20892., Snow AL; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814., Holland SM; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892., Biggs CM; Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC V6H 0B3, Canada., Moncada-Vélez M; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065., Arias AA; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065.; Primary Immunodeficiencies Group, University of Antioquia UdeA, 050010 Medellin, Colombia.; School of Microbiology, University of Antioquia UdeA, 050010 Medellin, Colombia., Lorenzo L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France., Boucherit S; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France., Anglicheau D; Department of Nephrology and Transplantation, Necker University Hospital, Assistance Publique-Hôpitaux de Paris, 75743 Paris, France.; Institut Necker Enfants Malades, INSERM U1151-CNRS UMR 8253, Université de Paris, 75015 Paris, France., Planas AM; Institute for Biomedical Research, Spanish National Research Council, 08036 Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, 08036 Barcelona, Spain., Haerynck F; Department of Paediatric Immunology and Pulmonology, Center for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, 9000 Ghent, Belgium., Duvlis S; Faculty of Medical Sciences, University 'Goce Delchev,' Štip 2000, Republic of North Macedonia.; Institute of Public Health of the Republic of North Macedonia, Skopje 1000, Republic of North Macedonia., Ozcelik T; Department of Molecular Biology and Genetics, Bilkent University, 06800 Ankara, Turkey., Keles S; Meram Faculty of Medicine, Necmettin Erbakan University, 42080 Konya, Turkey., Bousfiha AA; Clinical Immunology Unit, Department of Pediatric Infectious Disease, Centre Hospitalier-Universitaire Ibn Roucshd, 20360 Casablanca, Morocco.; Laboratoire d'Immunologie Clinique, Inflammation et Allergie (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, 20250 Casablanca, Morocco., El Bakkouri J; Clinical Immunology Unit, Department of Pediatric Infectious Disease, Centre Hospitalier-Universitaire Ibn Roucshd, 20360 Casablanca, Morocco.; Laboratoire d'Immunologie Clinique, Inflammation et Allergie (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, 20250 Casablanca, Morocco., Ramirez-Santana C; Center for Autoimmune Disease Research, School of Medicine and Health Sciences, Universidad del Rosario, 111211 Bogotá, Colombia., Paul S; Department of Immunology, CIC1408, Groupe sur l'Immunité des Muqueuses et des Agents Pathogènes (GIMAP) Centre International de Recherche en Infectiologie, INSERM U1111, University Hospital of Saint-Étienne, 42000 Saint-Étienne, France., Pan-Hammarström Q; Department of Biosciences and Nutrition, Karolinska Institutet, 171 77 Stockholm, Sweden., Hammarström L; Department of Biosciences and Nutrition, Karolinska Institutet, 171 77 Stockholm, Sweden., Dupont A; University of Lille, INSERM, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1011-European Genomic Institute for Diabetes (EGID), F-59000 Lille, France., Kurolap A; The Genetics Institute and Genomics Center, Tel Aviv Sourasky Medical Center, 6423906 Tel Aviv, Israel., Metz CN; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY 11030., Aiuti A; Vita-Salute San Raffaele University, and Clinical Genomics, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, 20132 Milan, Italy., Casari G; Vita-Salute San Raffaele University, and Clinical Genomics, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, 20132 Milan, Italy., Lampasona V; Diabetes Research Institute, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, 20132 Milan, Italy., Ciceri F; Hematology and Bone Marrow Transplantation Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele University Vita-Salute San Raffaele, 20132 Milano, Italy., Barreiros LA; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, 05508-060 São Paulo, Brazil., Dominguez-Garrido E; Fundación Rioja Salud, Centro de Investigación Biomédica de La Rioja, 26006 Logroño, Spain., Vidigal M; University of São Paulo, 05508-060 São Paulo, Brazil., Zatz M; University of São Paulo, 05508-060 São Paulo, Brazil., van de Beek D; Department of Neurology, Amsterdam UMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands., Sahanic S; Department of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria., Tancevski I; Department of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria., Stepanovskyy Y; Shupyk National Healthcare University of Ukraine, 04112 Kyiv, Ukraine., Boyarchuk O; Department of Children's Diseases and Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, 46022 Ternopil, Ukraine., Nukui Y; Department of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University, Tokyo 113-8655, Japan., Tsumura M; Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan., Vidaur L; Intensive Care Medicine, Donostia University Hospital, Biodonostia Institute of Donostia, 20014 San Sebastián, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain., Tangye SG; Garvan Institute of Medical Research, Sydney, NWS 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine and Health, University of New South Wales, Sydney, NWS 2010, Australia., Burrel S; Sorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié Salpêtrière, Service de Virologie, 75013 Paris, France., Duffy D; Translational Immunology Unit, Institut Pasteur, Université Paris Cité, 75015 Paris, France., Quintana-Murci L; Human Evolutionary Genetics Unit, Institut Pasteur, CNRS UMR 2000, 75015 Paris, France.; Department of Human Genomics and Evolution, Collège de France, 75231 Paris, France., Klocperk A; Department of Immunology, 2nd Faculty of Medicine, Charles University and University Hospital in Motol, 150 06 Prague, Czech Republic., Kann NY; Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia 117997., Shcherbina A; Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia 117997., Lau YL; Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong 999077, China., Leung D; Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong 999077, China., Coulongeat M; Division of Geriatric Medicine, Tours University Medical Center, 37044 Tours, France., Marlet J; INSERM U1259, Morphogenèse et Antigénicité du VIH et des Virus des Hépatites (MAVIVH), Université de Tours, 37044 Tours, France.; Service de Bactériologie, Virologie et Hygiène Hospitalière, Centre Hospitalier Universitaire de Tours, 37044 Tours, France., Koning R; Department of Neurology, Amsterdam UMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands., Reyes LF; Department of Microbiology, Universidad de La Sabana, 250001 Chía, Colombia.; Department of Critical Care Medicine, Clínica Universidad de La Sabana, 250001 Chía, Colombia., Chauvineau-Grenier A; Service de Biologie Médicale, Centre Hospitalier Intercommunal Robert Ballanger, 93600 Aulnay-sous-Bois, France., Venet F; Laboratoire d'Immunologie, Hospices Civils de Lyon, Hôpital Edouard Herriot, 69437 Lyon, France.; Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, 69007 Lyon, France.; EA 7426, Pathophysiology of Injury-Induced Immunosuppression, Université Claude Bernard Lyon 1, Hospices Civils de Lyon, BioMérieux, Hôpital Edouard Herriot, 69437 Lyon, France., Monneret G; Laboratoire d'Immunologie, Hospices Civils de Lyon, Hôpital Edouard Herriot, 69437 Lyon, France.; EA 7426, Pathophysiology of Injury-Induced Immunosuppression, Université Claude Bernard Lyon 1, Hospices Civils de Lyon, BioMérieux, Hôpital Edouard Herriot, 69437 Lyon, France., Nussenzweig MC; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065.; HHMI, Rockefeller University, New York, NY 10065., Arrestier R; Service de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, 94010 Créteil, France.; Groupe de Recherche Clinique Cardiovascular and Respiratory Manifestations of Acute Lung Injury and Sepsis (CARMAS), Faculté de santé de Créteil, Université Paris Est Créteil, 94010 Créteil Cedex, France., Boudhabhay I; Department of Nephrology and Transplantation, Necker University Hospital, Assistance Publique-Hôpitaux de Paris, 75743 Paris, France.; Institut Necker Enfants Malades, INSERM U1151-CNRS UMR 8253, Université de Paris, 75015 Paris, France., Baris-Feldman H; The Genetics Institute and Genomics Center, Tel Aviv Sourasky Medical Center, 6423906 Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, 6997801 Tel Aviv, Israel., Hagin D; Sackler Faculty of Medicine, Tel Aviv University, 6997801 Tel Aviv, Israel.; Allergy and Clinical Immunology Unit, Department of Medicine, Tel Aviv Sourasky Medical Center, 6423906 Tel Aviv, Israel., Wauters J; Medical Intensive Care Unit, University Hospitals Leuven, 3000 Leuven, Belgium., Meyts I; Laboratory of Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.; Department of Pediatrics, Jeffrey Modell Diagnostic and Research Network Center, University Hospitals Leuven, 3000 Leuven, Belgium., Dyer AH; Department of Age-Related Healthcare, Tallaght University Hospital, Dublin D24 NR0A, Ireland.; Department of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin D08 W9RT, Ireland., Kennelly SP; Department of Age-Related Healthcare, Tallaght University Hospital, Dublin D24 NR0A, Ireland.; Department of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin D08 W9RT, Ireland., Bourke NM; Department of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin D08 W9RT, Ireland., Halwani R; Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, 27272 Sharjah, United Arab Emirates.; Immunology Research Lab, College of Medicine, King Saud University, 11362 Riyadh, Saudi Arabia., Sharif-Askari FS; Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, 27272 Sharjah, United Arab Emirates., Dorgham K; Sorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, 75013 Paris, France., Sallette J; Cerba HealthCare, 92130 Issy-les-Moulineaux, France., Sedkaoui SM; Cerba HealthCare, 92130 Issy-les-Moulineaux, France., AlKhater S; Department of Pediatrics, King Fahad Hospital of the University, Al Khobar 34445, Saudi Arabia.; College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia., Rigo-Bonnin R; Department of Clinical Laboratory, Hospital Universitari de Bellvitge, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain., Morandeira F; Department of Immunology, Hospital Universitari de Bellvitge, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain., Roussel L; Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, QC H4A 3J1, Canada.; Infectious Disease Susceptibility Program, Research Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada., Vinh DC; Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, QC H4A 3J1, Canada.; Infectious Disease Susceptibility Program, Research Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, 8000 Aarhus, Denmark., Condino-Neto A; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, 05508-060 São Paulo, Brazil., Prando C; Faculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe, 80250-200 Curitiba, Brazil., Bondarenko A; Shupyk National Healthcare University of Ukraine, 04112 Kyiv, Ukraine., Spaan AN; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065.; Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Gilardin L; Service de Médecine Interne, Hôpital Universitaire Jean-Verdier, Assistance Publique-Hôpitaux de Paris, 93140 Bondy, France.; INSERM U1138, Centre de Recherche des Cordeliers, 75006 Paris, France., Fellay J; School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.; Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland., Lyonnet S; Imagine Institute, Université de Paris, INSERM, UMR 1163, 75015 Paris, France., Bilguvar K; Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT 06511.; Department of Genetics, Yale University School of Medicine, New Haven, CT 06520.; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510.; Department of Medical Genetics, Acibadem University School of Medicine, 34750 Istanbul, Turkey., Lifton RP; Institute for Biomedical Research, Spanish National Research Council, 08036 Barcelona, Spain.; Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT 06511.; Department of Genetics, Yale University School of Medicine, New Haven, CT 06520., Mane S; Department of Genetics, Yale University School of Medicine, New Haven, CT 06520., Anderson MS; Institut d'Investigacions Biomèdiques August Pi i Sunyer, 08036 Barcelona, Spain., Boisson B; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065., Béziat V; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065., Zhang SY; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065., Andreakos E; Laboratory of Immunobiology, Center for Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece., Hermine O; Imagine Institute, University of Paris, 75015 Paris, France.; Department of Paediatric Immunology and Pulmonology, Center for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, 9000 Ghent, Belgium., Pujol A; Neurometabolic Diseases Laboratory, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain.; Centre for Biomedical Research on Rare Diseases (CIBERER) U759, Instituto de Salud Carlos III, 28029 Madrid, Spain.; Catalan Institution of Research and Advanced Studies (ICREA), 08010 Barcelona, Spain., Peterson P; Institute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, Estonia., Mogensen TH; Department of Infectious Diseases, Aarhus University Hospital, 8000 Aarhus, Denmark.; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Rowen L; Institute for Systems Biology, Seattle, WA 98109., Mond J; ADMA Biologics Inc., Ramsey, NJ 07446., Debette S; University of Bordeaux, INSERM, Bordeaux Population Health Center, UMR1219, F-33000 Bordeaux, France.; Department of Neurology, Institute of Neurodegenerative Diseases, Bordeaux University Hospital, F-33000 Bordeaux, France., de Lamballerie X; Institut Hospitalo-Universitaire Méditerranée Infection, Unité des Virus Émergents, Aix-Marseille University, Institut pour la Recherche et le Développment (IRD) 190, INSERM 1207, 13005 Marseille, France., Burdet C; Epidémiologie clinique du Centre d'Investigation Clinique (CIC-EP), INSERM CIC 1425, Hôpital Bichat, 75018 Paris, France.; Université de Paris, Infection Antimicrobials Modelling Evolution (IAME), UMR 1137, INSERM, 75870 Paris, France.; Département Epidémiologie, Biostatistiques et Recherche Clinique, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, 75018 Paris, France., Bouadma L; Université de Paris, Infection Antimicrobials Modelling Evolution (IAME), UMR 1137, INSERM, 75870 Paris, France.; Service de Réanimation Médicale et des Maladies Infectieuses, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Nord Université de Paris, F-75018 Paris, France., Zins M; Cohorte Constances Groupe Hospitalier Universitaire centre, Assistance Publique-Hôpitaux de Paris, Université de Paris, 94800 Villejuif, France., Soler-Palacin P; Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain., Colobran R; Immunology Division, Genetics Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain., Gorochov G; Sorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, 75013 Paris, France.; Département d'Immunologie, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpétrière, 75015 Paris, France., Solanich X; Department of Internal Medicine, Hospital Universitari de Bellvitge, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain., Susen S; University of Lille, INSERM, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1011-European Genomic Institute for Diabetes (EGID), F-59000 Lille, France., Martinez-Picado J; IrsiCaixa AIDS Research Institute, 08916 Badalona, Spain.; Institute for Health Science Research Germans Trias i Pujol (IGTP), 08916 Badalona, Spain.; Department of Infectious Diseases and Immunity, University of Vic-Central University of Catalonia, 08500 Vic, Spain.; Catalan Institution of Research and Advanced Studies (ICREA), 08010 Barcelona, Spain.; Consorcio Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain., Raoult D; Microbes, Evolution, Phylogénie et Infection (MEPHI), Institut Hospitalo-Universitaire Méditerranée Infection, Institut de Recherche pour le Développement, Assistance Publique Hôpitaux de Marseille, Aix-Marseille Université, 13005 Marseille, France., Vasse M; Service de Biologie Clinique and UMR-S 1176, Hôpital Foch, 92150 Suresnes, France., Gregersen PK; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY 11030., Piemonti L; Diabetes Research Institute, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, 20132 Milan, Italy., Rodríguez-Gallego C; Department of Clinical Sciences, Universidad Fernando Pessoa Canarias, 35450 Las Palmas de Gran Canaria, Spain.; Department of Immunology, University Hospital of Gran Canaria Dr. Negrin, Canarian Health System, 35010 Las Palmas de Gran Canaria, Spain., Notarangelo LD; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892., Su HC; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Kisand K; Institute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, Estonia., Okada S; Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan., Puel A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065., Jouanguy E; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065., Rice CM; Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10065., Tiberghien P; Etablissement Français du Sang, 93218 La Plaine Saint-Denis, France.; Interactions Hôte-Greffon-Tumeur et Ingénierie Cellulaire et Génique (RIGHT), INSERM, Etablissement Français du Sang, Université de Franche-Comté, 25000 Besançon, France., Zhang Q; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065., Casanova JL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065.; HHMI, Rockefeller University, New York, NY 10065., Abel L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065., Cobat A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, University of Paris, 75015 Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 May 24; Vol. 119 (21), pp. e2200413119. Date of Electronic Publication: 2022 May 16.