Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II).

Autor: Jayatunga MK; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom., Thompson S; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom. Electronic address: sam.thompson@chem.ox.ac.uk., McKee TC; Center for Cancer Research, Molecular Targets Laboratory, Frederick National Laboratory Cancer Research, Frederick, MD 21702, USA., Chan MC; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom., Reece KM; NCI, Mol. Pharmacol. Sect., Med. Oncol. Branch, Ctr. Canc. Res., NIH, Bldg. 10, Room 5A01, 9000 Rockville Pike, Bethesda, MD 20892, USA., Hardy AP; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom., Sekirnik R; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom., Seden PT; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom., Cook KM; NCI, Mol. Pharmacol. Sect., Med. Oncol. Branch, Ctr. Canc. Res., NIH, Bldg. 10, Room 5A01, 9000 Rockville Pike, Bethesda, MD 20892, USA., McMahon JB; Center for Cancer Research, Molecular Targets Laboratory, Frederick National Laboratory Cancer Research, Frederick, MD 21702, USA., Figg WD; NCI, Mol. Pharmacol. Sect., Med. Oncol. Branch, Ctr. Canc. Res., NIH, Bldg. 10, Room 5A01, 9000 Rockville Pike, Bethesda, MD 20892, USA. Electronic address: figgw@helix.nih.gov., Schofield CJ; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom., Hamilton AD; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom. Electronic address: andrew.hamilton@admin.ox.ac.uk.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2015 Apr 13; Vol. 94, pp. 509-16. Date of Electronic Publication: 2014 Jun 27.

Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1.

Autor: Egleton JE; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK., Thinnes CC; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK., Seden PT; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK., Laurieri N; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK., Lee SP; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK., Hadavizadeh KS; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK., Measures AR; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK., Jones AM; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK., Thompson S; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK., Varney A; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK., Wynne GM; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK., Ryan A; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK; Faculty of Science, Engineering and Computing, University of Kingston, KT1 2EE, UK., Sim E; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK; Faculty of Science, Engineering and Computing, University of Kingston, KT1 2EE, UK., Russell AJ; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. Electronic address: angela.russell@chem.ox.ac.uk.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2014 Jun 01; Vol. 22 (11), pp. 3030-54. Date of Electronic Publication: 2014 Mar 28.

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages.

Autor: Abuhammad A; Department of Pharmacology, University of Oxford, Oxford, United Kingdom., Fullam E, Lowe ED, Staunton D, Kawamura A, Westwood IM, Bhakta S, Garner AC, Wilson DL, Seden PT, Davies SG, Russell AJ, Garman EF, Sim E

Publikováno v: PloS one [PLoS One] 2012; Vol. 7 (12), pp. e52790. Date of Electronic Publication: 2012 Dec 28.

Total synthesis of the marine metabolite (-)-clavosolide D.

Autor: Seden PT; School of Chemistry, University of Bristol, Cantock's Close, Bristol, U.K., Charmant JP, Willis CL

Publikováno v: Organic letters [Org Lett] 2008 Apr 17; Vol. 10 (8), pp. 1637-40. Date of Electronic Publication: 2008 Mar 21.