Combined EGFR and ROCK Inhibition in Triple-negative Breast Cancer Leads to Cell Death Via Impaired Autophagic Flux

Autor: Stamatia Rontogianni, Maarten Altelaar, Sander van Doorn, Daniel S. Peeper, Sedef Iskit

Publikováno v: Mol Cell Proteomics

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with very limited therapeutic options. We have recently shown that the combined inhibition of EGFR and ROCK in TNBC cells results in cell death, however, the underlying me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cabd9158b8bf0c8df2fae69fc8d2e6
https://europepmc.org/articles/PMC7000121/

Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival

Autor: Lodewyk F. A. Wessels, Daniel S. Peeper, Andreas Schlicker, Sedef Iskit

Publikováno v: Oncotarget

Fra-1 (Fos-related antigen-1) is a member of the AP-1 (activator protein-1) family of transcription factors. We previously showed that Fra-1 is necessary for breast cancer cells to metastasize in vivo, and that a classifier comprising genes that are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc319f8aebe5c6a05b76a59865d320e
http://europepmc.org/articles/PMC4791222

Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer

Autor: Sedef Iskit, Daniel S. Peeper, Aida Shahrabi, Pasi Halonen, Patricia A. Possik, Cor Lieftink, Roderick L. Beijersbergen

Publikováno v: Oncotarget, 7(28), 42859-42872. Impact Journals
Iskit, S, Lieftink, C, Halonen, P, Shahrabi, A, Possik, P A, Beijersbergen, R L & Peeper, D S 2016, ' Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer ', Oncotarget, vol. 7, no. 28, pp. 42859-42872 . https://doi.org/10.18632/oncotarget.10230
Oncotarget

Breast cancer is the second most common cause of cancer-related deaths worldwide among women. Despite several therapeutic options, 15% of breast cancer patients succumb to the disease owing to tumor relapse and acquired therapy resistance. Particular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b2e2a76375475dfd26f61f987f1eb1
https://research.vumc.nl/en/publications/a7697ee0-2515-4fac-a7a9-94858798e39b