Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Seddon Y, Thomas"'
Autor:
Gregory S. Whitehead, Seddon Y. Thomas, Keiko Nakano, Derek J. Royer, Catherine G. Burke, Hideki Nakano, Donald N. Cook
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
The intensity and longevity of inflammatory responses to inhaled allergens is determined largely by the balance between effector and regulatory immune responses, but the mechanisms that determine the relative magnitudes of these opposing forces remai
Externí odkaz:
https://doaj.org/article/68c891eaece8469ca1404ec09b7ac379
Autor:
Brita Kilburg-Basnyat, Debra A. Tokarz, Sanjay Varikuti, Jennifer H. Madenspacher, Robert M. Tighe, Myles X Hodge, Michael B. Fessler, Sky W Reece, Kymberly M. Gowdy, Seddon Y. Thomas, Katelyn Dunigan-Russell, Donald N. Cook, Bin Luo
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Asthma is a common respiratory disease currently affecting more than 300 million worldwide and is characterized by airway inflammation, hyperreactivity, and remodeling. It is a heterogeneous disease consisting of corticosteroid-sensitive T-helper cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e7f28b0bbf7b93cec00d20a5d5c2e9
https://doi.org/10.1165/rcmb.2020-0007oc
https://doi.org/10.1165/rcmb.2020-0007oc
Autor:
Gregory S. Whitehead, Seddon Y. Thomas, Keiko Nakano, Derek J. Royer, Catherine G. Burke, Hideki Nakano, Donald N. Cook
Publikováno v:
JCI insight. 7(4)
The intensity and longevity of inflammatory responses to inhaled allergens is determined largely by the balance between effector and regulatory immune responses, but the mechanisms that determine the relative magnitudes of these opposing forces remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a16448a6a449937f5e4c29af62ba20
https://pubmed.ncbi.nlm.nih.gov/35191395
https://pubmed.ncbi.nlm.nih.gov/35191395
Autor:
Jerry A. Nick, Julie M. Meacham, Renee D. Stapleton, Edward Abraham, Michael B. Fessler, Donald N. Cook, William J. Janssen, Seddon Y. Thomas, Carmen Mikacenic, Jeffrey G. McDonald, Mark M. Wurfel, Kymberly M Gowdy, Ginger W. Muse, Jennifer Martinez, Bonne M. Thompson, Mary Jane Thomassen, Stavros Garantziotis, Jennifer H. Madenspacher, Eric D. Morrell
Publikováno v:
JCI Insight
Alveolar macrophages (AM) play a central role in initiation and resolution of lung inflammation, but the integration of these opposing core functions is poorly understood. AM expression of cholesterol 25-hydroxylase (CH25H), the primary biosynthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47bea17f8999073ec76ae01e5764a3a
https://pubmed.ncbi.nlm.nih.gov/32343675
https://pubmed.ncbi.nlm.nih.gov/32343675
Autor:
K. Ton, David A. D'Alessandro, M. Villavicencio-Theoduloz, M. Prario, Erin Coglianese, Seddon Y. Thomas, J. Richards, K. Drezek, A. Gallandt
Publikováno v:
The Journal of Heart and Lung Transplantation. 40:S430-S431
Purpose Left Ventricular Assist Devices (LVADs) are a leading treatment for advanced heart failure. However, it is primarily major medical centers that have the resources to support an LVAD program. Many patients live far from an implant center, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5e39b1b2c96057c257b8db3cf5fb2d4
https://doi.org/10.1016/j.healun.2021.01.1201
https://doi.org/10.1016/j.healun.2021.01.1201
Autor:
Imtiaz A Khan, Seddon Y Thomas, Magali M Moretto, Frederick S Lee, Sabina A Islam, Crescent Combe, Joseph D Schwartzman, Andrew D Luster
Publikováno v:
PLoS Pathogens, Vol 2, Iss 6, p e49 (2006)
The host response to intracellular pathogens requires the coordinated action of both the innate and acquired immune systems. Chemokines play a critical role in the trafficking of immune cells and transitioning an innate immune response into an acquir
Externí odkaz:
https://doaj.org/article/4567ffbc98584134ad92c3e22ca4a72f
Autor:
Donald N. Cook, Jonathan S. Serody, Ge Zhang, Jenny P.-Y. Ting, Xian Chen, Yisong Y. Wan, Xiaojiang Xu, Paul A. Wade, Bing Wu, Song Zhang, Qing Kong, Seddon Y. Thomas, Motoki Takaku, Wei-Chun Chou, Liyun Zou, Ai Di Gu
Publikováno v:
Nature. 551:105-109
T helper 17 (TH17) cells are critically involved in host defence, inflammation, and autoimmunity. Transforming growth factor β (TGFβ) is instrumental in TH17 cell differentiation by cooperating with interleukin-6 (refs 6, 7). Yet, the mechanism by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d17900e0a17c776c6c8465232bb18881
https://doi.org/10.1038/nature24283
https://doi.org/10.1038/nature24283
Autor:
Keiko Nakano, Miranda R. Lyons-Cohen, Seddon Y. Thomas, G S Whitehead, Hideki Nakano, Donald N. Cook, Paul A. Wade, Motoki Takaku, Kymberly M. Gowdy, Xiaojiang Xu, James M. Ward
Publikováno v:
Mucosal immunology
Sensitization to inhaled allergens is dependent on activation of conventional dendritic cells (cDCs) and on the adaptor molecule, MyD88. However, many cell types in the lung express Myd88, and it is unclear how signaling in these different cell types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c5c01e350c12d9f18ee7490b872732
http://europepmc.org/articles/PMC5918466
http://europepmc.org/articles/PMC5918466
Autor:
David A. D'Alessandro, Seddon Y. Thomas, K. Milley, Erin Coglianese, Denise W. Gee, L. Irwin, Janice M. Camuso, K. Flanders, Gregory D. Lewis, T. Logan
Publikováno v:
The Journal of Heart and Lung Transplantation. 39:S494-S495
Purpose Patients in end stage heart failure with a BMI >35 are considered unacceptable candidates for heart transplantation due to increased morbidity and mortality after transplant. Those with a left ventricular assist device (LVAD) may struggle los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c013f262de3c40b9859430deb10260b
https://doi.org/10.1016/j.healun.2020.01.078
https://doi.org/10.1016/j.healun.2020.01.078
Autor:
Donald N. Cook, Gentaro Izumi, Seddon Y. Thomas, Alexander Medvedev, Hideki Nakano, Hong Soon Kang, Gregory S. Whitehead, Keiko Nakano, Anton M. Jetten, Tadeusz P Karcz, Sergei S. Makarov
Publikováno v:
JCI Insight. 4
Airway neutrophilia occurs in approximately 50% of patients with asthma and is associated with particularly severe disease. Unfortunately, this form of asthma is usually refractory to corticosteroid treatment, and there is an unmet need for new thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d465e2168b15ac16b5cd7ca75bed2642
https://doi.org/10.1172/jci.insight.125528
https://doi.org/10.1172/jci.insight.125528