Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Seda Onder"'
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254450 (2021)
Isopeptide crosslinked proteins can be the product of transglutaminase or of exposure to organophosphorus toxicants (OP). Transglutaminase links glutamine to lysine with loss of ammonia. OP toxicants induce a link between glutamic acid and lysine wit
Externí odkaz:
https://doaj.org/article/f71f9d78cba4493881187d548b22dde3
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Human butyrylcholinesterase (BChE) is purified in large quantities from Cohn fraction IV-4 to use for protection against the toxicity of chemical warfare agents. Small scale preliminary experiments use outdated plasma from the American Red Cross as t
Externí odkaz:
https://doaj.org/article/5ef6f000670b45a3b0fcefcf272f8f11
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Hupresin is a new affinity resin that binds butyrylcholinesterase (BChE) in human plasma and acetylcholinesterase (AChE) solubilized from red blood cells (RBC). Hupresin is available from the CHEMFORASE company. BChE in human plasma binds to Hupresin
Externí odkaz:
https://doaj.org/article/306a5261570548f0ae06ec4dc404d69d
Publikováno v:
Chemical Research in Toxicology. 35:1570-1578
Exposure to organophosphorus pesticides (OP) can have chronic adverse effects that are independent of inhibition of acetylcholinesterase, the classic target for acute OP toxicity. In pure proteins, the organophosphorus pesticide chlorpyrifos oxon ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6263da828f1c58ea1652c60c060778ae
https://doi.org/10.1021/acs.chemrestox.2c00194
https://doi.org/10.1021/acs.chemrestox.2c00194
Publikováno v:
Neurotoxicology
Cultured SH-SY5Y human neuroblastoma cells are used in neurotoxicity assays. These cells express markers of the cholinergic and dopaminergic systems. Acetylcholinesterase (AChE) activity has been reported in these cells. Neurotoxic organophosphate co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c6914486963965bc4cf4fac2371c2d
https://doi.org/10.1016/j.neuro.2022.02.006
https://doi.org/10.1016/j.neuro.2022.02.006
Publikováno v:
Drug Development Research. 83:900-909
Amyloid precursor-like protein-2 (APLP2) and its C-terminal fragments (CTFs) are expressed at high levels in pancreatic cancer cells and knockdown of APLP2 expression inhibits tumor growth. CTFs are released from APLP2 by beta-secretase (BACE). In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6320a3634c74f0b665f5a36bcf7026
https://doi.org/10.1002/ddr.21915
https://doi.org/10.1002/ddr.21915
Autor:
Gaoping Xiao, Seda Onder, Daan Noort, Oksana Lockridge, Lawrence M. Schopfer, A. Fidder, Udaya Yerramalla, Ozden Tacal, Marco van Grol
Publikováno v:
Journal of Proteome Research
Chronic low-dose exposure to organophosphorus pesticides is associated with the risk of neurodegenerative disease. The mechanism of neurotoxicity is independent of acetylcholinesterase inhibition. Adducts on tyrosine, lysine, threonine, and serine ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9082411d7a68d6e70c2d1050b434502
https://doi.org/10.1021/acs.jproteome.1c00383
https://doi.org/10.1021/acs.jproteome.1c00383
Publikováno v:
Chemico-biological interactions. 366
Alzheimer's disease (AD) is characterized by extracellular amyloid plaques composed of amyloid-β peptide (Aβ), intracellular neurofibrillary tangles containing hyperphosphorylated tau protein and neuronal loss. Most of the FDA-approved AD drugs cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0004839b1b627a021f0965162bcdf5ec
https://pubmed.ncbi.nlm.nih.gov/36027949
https://pubmed.ncbi.nlm.nih.gov/36027949
Publikováno v:
Chemico-biological interactions. 363
Epidemiological evidence suggests that people chronically exposed to organophosphorus pesticides are at increased risk of neurodegenerative disease. Covalently linked amyloid beta dimers have been isolated from the brains of Alzheimer's patients. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e286484a29865b13aac21a58950161
https://pubmed.ncbi.nlm.nih.gov/35779611
https://pubmed.ncbi.nlm.nih.gov/35779611
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254450 (2021)
PLoS ONE
PLoS ONE
Isopeptide crosslinked proteins can be the product of transglutaminase or of exposure to organophosphorus toxicants (OP). Transglutaminase links glutamine to lysine with loss of ammonia. OP toxicants induce a link between glutamic acid and lysine wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3615f4bac8d1c1a921161a014cd82f1e
https://aperta.ulakbim.gov.tr/record/233718
https://aperta.ulakbim.gov.tr/record/233718
