Výsledky vyhledávání

Akademický článek

Effects of Sulfur Containing Glycine Imine Derivatives Compounds on Multidrug Resistance Proteins (MRPs) and Apoptosis Mechanism in MCF-7 and DLD-1 Cell Lines

Autor: Seda MESCİ, Burak YAZGAN, Melek GÜL, Tuba YILDIRIM

Publikováno v: Bezmiâlem Science, Vol 10, Iss 4, Pp 461-469 (2022)

Objective:Glutathione (GSH) is a tripeptide consisting of glycine, glutamic acid and cysteine. If the sulfur containing amino acids like methionine and cysteine increase in the cells, the level of GSH increases. GSH is one of the most important and p

Externí odkaz: https://doaj.org/article/b31990026add4ab79a0a69428026fe28

Zobrazit plný text záznamu

Akademický článek

ATP‐Binding Cassette Transporters Mediated Chemoresistance in MCF-7 Cells: Modulation by PhTAD-Substituted Dihydropyrrole Compounds

Autor: Burak YAZGAN, Seda MESCİ, Maşuk AKŞAHIN, Arif AYAR, Melek GÜL, Tuba YILDIRIM

Publikováno v: Ahi Evran Medical Journal, Vol 6, Iss 1, Pp 77-85 (2022)

Purpose: ABC proteins transport many substrates such as antibiotics and drugs. Increase of ABCs lead chemoresistance in cancer. In view of this information, in our study, we planned to investigate both PhTAD-substituted dihydropyrrole compound's imp

Externí odkaz: https://doaj.org/article/5dd289eaf318407fa0f7c510a8517957

Zobrazit plný text záznamu

Akademický článek

Antiproliferative Activity of Pyrrolidine Derivatives compound in Colon Cancer Cells

Autor: Seda Mesci, Melek Gül, Tuba Yıldırım

Publikováno v: Hitit Medical Journal, Vol 4, Iss 1, Pp 1-5 (2022)

Objective: Anti-cancer drug research plays an important role for chemotherapeutic treatments in various types of cancer. Pyrolidine derived compounds have been reported by many researchers to be a potent anti-cancer compound. It is aimed to investiga

Externí odkaz: https://doaj.org/article/4ad20808a6194190a5b12e55b79c728f

Zobrazit plný text záznamu

Akademický článek

A Multidisciplinary Approach to Coronavirus Disease (COVID-19)

Autor: Aliye Gediz Erturk, Arzu Sahin, Ebru Bati Ay, Emel Pelit, Emine Bagdatli, Irem Kulu, Melek Gul, Seda Mesci, Serpil Eryilmaz, Sirin Oba Ilter, Tuba Yildirim

Publikováno v: Molecules, Vol 26, Iss 12, p 3526 (2021)

Since December 2019, humanity has faced an important global threat. Many studies have been published on the origin, structure, and mechanism of action of the SARS-CoV-2 virus and the treatment of its disease. The priority of scientists all over the w

Externí odkaz: https://doaj.org/article/76ffea753fe04e44aa41307247277164

Zobrazit plný text záznamu

Plný text ve formátu HTML

Antioxidant, Cytotoxic Activity and Pharmacokinetic Studies by Swiss Adme, Molinspiration, Osiris and DFT of PhTAD-substituted Dihydropyrrole Derivatives

Autor: Melek Gul, Burak Yazgan, Masuk Aksahin, Arif Ayar, Tuba Yildirim, Seda Mesci

Publikováno v: Current Computer-Aided Drug Design. 18:52-63

Background: Pyrrole compounds having a heterocyclic structure are the most researched and biological activities such as antioxidant and anticancer activities. Objective: Herein is a first effort to study the significance of heterocyclic compounds to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915f1af4a82f2134060e536c369a53da
https://doi.org/10.2174/1573409917666210223105722

Zobrazit plný text záznamu

Zinc and phosphorus fertilization in Galanthus elwesii Hook: Changes in the total alkaloid, flavonoid, and phenolic content, and evaluation of anti-cancer, anti-microbial, and antioxidant activities

Autor: Ebru Batı Ay, Muhammed Akif Açıkgöz, Beril Kocaman, Seda Mesci, Berna Kocaman, Tuba Yıldırım

Publikováno v: Scientia Horticulturae. 317:112034

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02dc1e3d15aa15d8139510f5c8b6d5cd
https://doi.org/10.1016/j.scienta.2023.112034

Zobrazit plný text záznamu

PhTAD-Substituted Dihydropyrrole Compounds Regulate Apoptotic Cell Death in MCF-7 Cells

Autor: Masuk Aksahin, Burak Yazgan, Tuba Yildirim, Seda Mesci, Melek Gul, Arif Ayar

Publikováno v: Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 14:737-750

Breast cancer is the most common type of cancer amongst women. Apoptosis is known as a programmed cell death and this mechanism induces cancer cell death. Dihydropyrrole compounds contain a heterocyclic structure and these molecules have many biologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba32ccef45e15f8302b062cf41a75651
https://doi.org/10.18185/erzifbed.894125

Zobrazit plný text záznamu

ANTIPROLIFERATIVE ACTIVITY OF PYRROLIDINE DERIVATIVES COMPOUND IN COLON CANCER CELLS

Autor: Seda MESCİ, Melek GÜL, Tuba YILDIRIM

Publikováno v: Hitit Medical Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a3433bc6507e4f3529c1f2f4acd5446
https://doi.org/10.52827/hititmedj.924278

Zobrazit plný text záznamu

ATP‐Binding Cassette Transporters Mediated Chemoresistance in MCF-7 Cells: Modulation by PhTAD-Substituted Dihydropyrrole Compounds

Autor: Burak YAZGAN, Seda MESCİ, Maşuk AKŞAHIN, Arif AYAR, Melek GÜL, Tuba YILDIRIM

Publikováno v: Ahi Evran Medical Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94bb3444ab6f6be59b61633453a12373
https://doi.org/10.46332/aemj.896830

Zobrazit plný text záznamu

The effect of ATP-binding cassette (ABC) transporters in human cancers

Autor: Burak Yazgan, Tuba Yildirim, Sevgi Marakli, Seda Mesci

Publikováno v: Volume: 1, Issue: 1 14-19
International Journal of Science Letters

Multi-drug resistance (MDR) can be defined as a negative effect on the drug-target relationships, decreasing in intracellular drug aggregation. ABC (ATP-binding cassette) are popular transporter proteins in the development of MDR. ABC proteins in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0723445729c529dae27723a91e0678
https://doi.org/10.38058/ijsl.594000

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání