Lack of in vivo cross-resistance with 4'-thio-ara-C against drug-resistant murine P388 and L1210 leukemias.

Autor: Waud WR, Gilbert KS, Secrist JA 3rd, Waud, William R, Gilbert, Karen S, Secrist, John A 3rd

Publikováno v: Cancer Chemotherapy & Pharmacology; Aug2011, Vol. 68 Issue 2, p399-403, 5p

The synthesis and biological evaluation of alkyl and benzyl naphthyridinium analogs of eupolauridine as potential antimicrobial and cytotoxic agents.

Autor: Taghavi-Moghadam S; Organic Chemistry Department, Southern Research Institute, 2000 Ninth Avenue South, PO Box 55305, Birmingham, AL 35255, United States., Kwong CD; Organic Chemistry Department, Southern Research Institute, 2000 Ninth Avenue South, PO Box 55305, Birmingham, AL 35255, United States., Secrist JA 3rd; Organic Chemistry Department, Southern Research Institute, 2000 Ninth Avenue South, PO Box 55305, Birmingham, AL 35255, United States. Electronic address: secrist@southernresearch.org., Khan SI; National Center for Natural Products Research, and Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677, United States., Clark AM; National Center for Natural Products Research, and Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677, United States.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2016 Dec 01; Vol. 24 (23), pp. 6119-6130. Date of Electronic Publication: 2016 Feb 23.

6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase.

Autor: Hassan AEA; Southern Research Institute, P.O. Box 55305, Birmingham, AL, 35255-5305, USA; Applied Nucleic Acids Research Centre, Zagazig University, Zagazig, PO Box 44519, Egypt. Electronic address: abdallaelsayed@zu.edu.eg., Abou-Elkhair RAI; Southern Research Institute, P.O. Box 55305, Birmingham, AL, 35255-5305, USA; Applied Nucleic Acids Research Centre, Zagazig University, Zagazig, PO Box 44519, Egypt., Parker WB; Southern Research Institute, P.O. Box 55305, Birmingham, AL, 35255-5305, USA; PNP Therapeutics Inc., 15 Richard Arrington Jr. Blvd North, Birmingham, AL, 35203, USA., Allan PW; Southern Research Institute, P.O. Box 55305, Birmingham, AL, 35255-5305, USA., Secrist JA 3rd; Southern Research Institute, P.O. Box 55305, Birmingham, AL, 35255-5305, USA.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2016 Jan 27; Vol. 108, pp. 616-622. Date of Electronic Publication: 2015 Dec 17.

Synthesis and SAR of geminal substitutions at the C5' carbosugar position of pyrimidine-derived HCV inhibitors.

Autor: Verma VA; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA. verma.vishal@gene.com, Rossman R, Bennett F, Chen L, Gavalas S, Girijavallabhan V, Huang Y, Kim SH, Kosinski A, Pinto P, Rizvi R, Shankar B, Tong L, Velazquez F, Venkatraman S, Kozlowski J, MacCoss M, Kwong CD, Bansal N, Kezar HS 3rd, Reynolds RC, Maddry JA, Ananthan S, Secrist JA 3rd, Li C, Chase R, Curry S, Huang HC, Tong X, Njoroge FG, Arasappan A

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Nov 15; Vol. 22 (22), pp. 6967-73. Date of Electronic Publication: 2012 Sep 07.

Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.

Autor: Bennett F; Merck Research Laboratories, Kenilworth, NJ 07033, USA. frank.bennett@merck.com, Kezar HS 3rd, Girijavallabhan V, Huang Y, Huelgas R, Rossman R, Shih NY, Piwinski JJ, MacCoss M, Kwong CD, Clark JL, Fowler AT, Geng F, Roychowdhury A, Reynolds RC, Maddry JA, Ananthan S, Secrist JA 3rd, Li C, Chase R, Curry S, Huang HC, Tong X, George Njoroge F, Arasappan A

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Aug 01; Vol. 22 (15), pp. 5144-9. Date of Electronic Publication: 2012 Jun 19.