Zobrazeno 1 - 10
of 2 096
pro vyhledávání: '"Secondary progressive"'
Publikováno v:
Неврология, нейропсихиатрия, психосоматика, Vol 16, Iss 0, Pp 88-90 (2024)
The article provides an analysis of modern methods of treatment of secondary progressive multiple sclerosis (SPMS). The only drug that has proven its effectiveness in all types of SPMS (with exacerbations and without exacerbations) is siponimod. Clin
Externí odkaz:
https://doaj.org/article/801c56066d954331893c62e836625fab
Autor:
Simone Agostini, Roberta Mancuso, Lorenzo Agostino Citterio, Domenico Caputo, Letizia Oreni, Riccardo Nuzzi, Maria Barbara Pasanisi, Marco Rovaris, Mario Clerici
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106648- (2024)
Relapsing-remitting (RR) Multiple Sclerosis (MS) is the most common form of the disease; RRMS patients can maintain their clinical phenotype throughout life or can develop a secondary progressive (SP) course over time. We investigated whether circula
Externí odkaz:
https://doaj.org/article/155bde9b0f7a46e59b1a6a54aa5eee59
Autor:
Clara G. Chisari, Umberto Aguglia, Maria Pia Amato, Roberto Bergamaschi, Antonio Bertolotto, Simona Bonavita, Vincenzo Brescia Morra, Paola Cavalla, Eleonora Cocco, Antonella Conte, Salvatore Cottone, Giovanna De Luca, Alessia Di Sapio, Massimo Filippi, Antonio Gallo, Claudio Gasperini, Franco Granella, Giacomo Lus, Davide Maimone, Giorgia Teresa Maniscalco, Girolama Marfia, Lucia Moiola, Damiano Paolicelli, Ilaria Pesci, Paolo Ragonese, Marco Rovaris, Giuseppe Salemi, Claudio Solaro, Rocco Totaro, Maria Trojano, Marika Vianello, Mauro Zaffaroni, Vito Lepore, Francesco Patti, Carlo Avolio, Roberto Balgera, Paola Banfi, Paolo Bellantonio, Placido Bramanti, Lorenzo Capone, Guido Cavalletti, Luca Chiveri, Raffaella Clerici, Marinella Clerico, Francesco Corea, Vincenzo Dattola, Francesca De Robertis, Giancarlo Di Battista, Simonetta Galgani, Maurizia Gatto, Maria Grazia Grasso, Matilde Inglese, Lorenzo Lo Russo, Francesco Ottavio Logullo, Renato Mantegazza, Alessandra Protti, Monica Rezzonico, Mariarosa Rottoli, Marco Salvetti, Elio Scarpini, Leonardo Sinisi, Maddalena Sparaco, Daniele Spitaleri, Tiziana Tassinari, Simone Tonietti, Paola Valentino, Franco Valzania, Simonetta Venturi
Publikováno v:
Neurotherapeutics, Vol 21, Iss 4, Pp e00363- (2024)
Treatment options for secondary progressive MS (SPMS) are limited, especially considering that the new drugs recently approved are licensed for actively relapsing patients. We aimed to compare the disability progression in a real-world cohort of SPMS
Externí odkaz:
https://doaj.org/article/26800f29a8714b44b0ce1491be5de728
Autor:
Verena Isabell Leussink, Manda Jankovic, Marie Groth, Katrin Schuh, Inessa Schwab Sauerbeck, Olaf Hoffmann
Publikováno v:
Brain and Behavior, Vol 14, Iss 6, Pp n/a-n/a (2024)
Abstract Background The revised Lublin classification offers a framework for categorizing multiple sclerosis (MS) according to the clinical course and imaging results. Diagnosis of secondary progressive MS (SPMS) is often delayed by a period of uncer
Externí odkaz:
https://doaj.org/article/954ea2297b7c425db81391a2d0ef1a74
Autor:
Rabeah Al-Temaimi, Raed Alroughani
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e32685- (2024)
Multiple sclerosis (MS) is a complex, neurodegenerative chronic disorder. Circulating diagnostic biomarkers for MS have remained elusive, and those proposed so far have limited sensitivity and specificity to MS. Plasma-circulating microRNAs (miRNAs)
Externí odkaz:
https://doaj.org/article/48b44601a9134a70bf246d11c8528da3
Autor:
Krizia Sanna, Antonio Bruno, Sara Balletta, Silvia Caioli, Monica Nencini, Diego Fresegna, Livia Guadalupi, Ettore Dolcetti, Federica Azzolini, Fabio Buttari, Roberta Fantozzi, Angela Borrelli, Mario Stampanoni Bassi, Luana Gilio, Gianluca Lauritano, Valentina Vanni, Francesca De Vito, Alice Tartacca, Fabrizio Mariani, Valentina Rovella, Alessandra Musella, Diego Centonze, Georgia Mandolesi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundSecondary progressive multiple sclerosis (SPMS) is defined by the irreversible accumulation of disability following a relapsing-remitting MS (RRMS) course. Despite treatments advances, a reliable tool able to capture the transition from RRM
Externí odkaz:
https://doaj.org/article/8487908276e1450781995b35527d24c5
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8850 (2024)
Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are two neuroprotective and anti-inflammatory molecules of the central nervous system (CNS). Both bind to three G protein-coupled receptors, namely PAC
Externí odkaz:
https://doaj.org/article/efe662440eed497bad3c01a05b090cc4
Autor:
Massimo Filippi, Laura Ferrè, Chiara Zanetta, Caterina Rizzi, Gabriella Pessina, Francesco Assogna, Maria A. Rocca
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Disease-modifying therapies (DMTs) for multiple sclerosis (MS) reduce relapse frequency, magnetic resonance imaging (MRI) activity, and slow disability progression. Numerous DMTs are approved for relapsing forms of MS although real-world data on pati
Externí odkaz:
https://doaj.org/article/ef54c05740f2416b8afe67eb74d099e0
Autor:
Crystal Watson, Dhanalakshmi Thirumalai, Arie Barlev, Eddie Jones, Sasha Bogdanovich, Kiren Kresa-Reahl
Publikováno v:
Neurology and Therapy, Vol 12, Iss 6, Pp 1961-1979 (2023)
Abstract Introduction Much of the current literature on treatment patterns and disability progression in multiple sclerosis (MS) does not distinguish between the relapsing–remitting and progressive subtypes (including primary [PPMS] and secondary p
Externí odkaz:
https://doaj.org/article/e5bed912d1c24028a5e2841dc4079259
Autor:
Priya Jhelum, Stephanie Zandee, Fari Ryan, Juan G. Zarruk, Bernhard Michalke, Vivek Venkataramani, Laura Curran, Wendy Klement, Alexandre Prat, Samuel David
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-22 (2023)
Abstract Ferroptosis is a form of lipid peroxidation-mediated cell death and damage triggered by excess iron and insufficiency in the glutathione antioxidant pathway. Oxidative stress is thought to play a crucial role in progressive forms of multiple
Externí odkaz:
https://doaj.org/article/18aee7bd8ba0455cb2561b0275634eaa