Zobrazeno 1 - 10
of 15 390
pro vyhledávání: '"Second Messenger System"'
Autor:
Val J. Watts, Tarsis F. Brust, Roland Seifert, Justin E. LaVigne, Katrina F. Ostrom, Carmen W. Dessauer, Rennolds S. Ostrom
Publikováno v:
Physiol Rev
Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9, that serve as major effector enzymes of G protein-coupled receptors (GPCRs). The trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ceb5e97ae2d30b573398a632376d578
https://doi.org/10.1152/physrev.00013.2021
https://doi.org/10.1152/physrev.00013.2021
Autor:
S Acreman, Quan Zhang
Publikováno v:
Chronic Diseases and Translational Medicine. 8:7-18
Glucagon is a potent glucose-elevating hormone that is secreted by pancreatic α-cells. While well-controlled glucagon secretion plays an important role in maintaining systemic glucose homeostasis and preventing hypoglycaemia, it is increasingly appa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c282ec335ee9f7a7af1b5091232743
https://doi.org/10.1016/j.cdtm.2021.06.001
https://doi.org/10.1016/j.cdtm.2021.06.001
Autor:
Jenna Gallie, Anuradha Mukherjee
Publikováno v:
Molecular Microbiology
Many bacteria form mats at the air-liquid interface of static microcosms. These structures typically involve the secretion of exopolysaccharide(s), the production of which is often controlled by the secondary messenger c-di-GMP. Mechanisms of mat for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a9f39ca160b9b8fb4931f95342e361
https://doi.org/10.1111/mmi.14855
https://doi.org/10.1111/mmi.14855
Autor:
Ru Yao, Chan Li, Baohua Ma, Sihai Lu, Jie Liu, Juncai Wei, Rui Xu, Xiaoe Zhao, Yaju Tang, Qiang Wei, Hui Zhang
Publikováno v:
Theriogenology. 176:35-42
G protein-coupled estrogen receptor (GPER), which is different from traditional estrogen nuclear receptors (ERs), mediates the rapid transduction of nongenomic signals in cells, and works by regulating transcription and intracellular second messenger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cf629b6fc04589d6d378f5182b2452
https://doi.org/10.1016/j.theriogenology.2021.09.010
https://doi.org/10.1016/j.theriogenology.2021.09.010
Publikováno v:
Mol Pharmacol
G protein-coupled receptors (GPCRs) transduce a diverse variety of extracellular stimuli into intracellular signaling. These receptors are the most clinically productive drug targets at present. Despite decades of research on the signaling consequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fae4ae514450ce94e0739a3973bb9f
https://doi.org/10.1124/molpharm.121.000332
https://doi.org/10.1124/molpharm.121.000332
Autor:
Adam C. Straub, Annie Beuve
Publikováno v:
Nitric Oxide
Soluble guanylyl cyclase (sGC, also called GC1) is the main receptor for nitric oxide (NO) that catalyzes the production of the second messenger molecule, 3′5′ cyclic guanosine monophosphate (cGMP) leading to vasorelaxation, and inhibition of leu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9dafbded8c18af59832d999533a3a1
https://doi.org/10.1016/j.niox.2021.09.008
https://doi.org/10.1016/j.niox.2021.09.008
Publikováno v:
Stem Cell Reviews and Reports. 18:1181-1192
Reactive oxygen species (ROS) play important roles as second messengers in a wide array of cellular processes including differentiation of stem cells. We identified Nox4 as the major ROS-generating enzyme whose expression is induced during differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3f37dfc695f4435d501193c37be874
https://doi.org/10.1007/s12015-021-10303-x
https://doi.org/10.1007/s12015-021-10303-x
Publikováno v:
Journal of Plant Research. 135:137-144
Cyclic AMP (cAMP) acts as a second messenger and is involved in the regulation of various physiological responses. Recently, we identified the cAMP-synthesis/hydrolysis enzyme CAPE, which contains the two catalytic domains adenylyl cyclase (AC) and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43dbec07dd096d47313918080780987e
https://doi.org/10.1007/s10265-021-01359-4
https://doi.org/10.1007/s10265-021-01359-4
Publikováno v:
Journal of Innate Immunity. 14:275-292
Within the last 60 years, microbiological research has challenged many dogmas such as bacteria being unicellular microorganisms directed by nutrient sources; these investigations produced new dogmas such as cyclic diguanylate monophosphate (cyclic di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc2feb62b70cc9304e158d97f1830cba
https://doi.org/10.1159/000519573
https://doi.org/10.1159/000519573
Autor:
Shamshad Cockcroft
Publikováno v:
Essays in Biochemistry
Lipids are essential constituents of cellular membranes. Once regarded merely as structural components, lipids have taken centre stage with the discovery of their roles in cell signalling and in the generation of bioactive metabolites. Lipids regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dad9bf8b2855a501437657d52360f14
http://europepmc.org/articles/PMC8578989
http://europepmc.org/articles/PMC8578989