Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Sebok K"'
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Interactions between extracellular matrix (ECM) proteins and β1 integrins play an essential role maintaining vascular integrity in the brain, particularly under vascular remodeling conditions. As blood vessels in the spinal cord are reporte
Externí odkaz:
https://doaj.org/article/2087fb5ca2174f71b2bd6bae24a15573
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract Background Maintaining a tight blood–brain barrier (BBB) is an important prerequisite for the preservation of neurological health, though current evidence suggests it declines with age. While extracellular matrix-integrin interactions play
Externí odkaz:
https://doaj.org/article/5d0b48c365d6408cb41c6c0149a70f6b
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 12, Pp 2557-2563 (2023)
The blood-brain barrier is a unique property of central nervous system blood vessels that protects sensitive central nervous system cells from potentially harmful blood components. The mechanistic basis of this barrier is found at multiple levels, in
Externí odkaz:
https://doaj.org/article/5760e6faad5447fe847950586b54f485
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-12 (2022)
Abstract Blood vessels in the central nervous system (CNS) are unique in having high electrical resistance and low permeability, which creates a selective barrier protecting sensitive neural cells within the CNS from potentially harmful components in
Externí odkaz:
https://doaj.org/article/0b6869dcd1ec4830857bbfa2e3f03ffb
Autor:
Sebok K. Halder, Richard Milner
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11235 (2023)
In response to chronic mild hypoxia (CMH, 8% O2), spinal cord blood vessels launch a robust angiogenic response that is associated with transient disruption of the blood–spinal cord barrier (BSCB) which, in turn, triggers a microglial vasculo-prote
Externí odkaz:
https://doaj.org/article/2e548c7ef42c41e9962aac536d91f501
Autor:
Sebok K. Halder, Richard Milner
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background Chronic mild hypoxia (CMH, 8% O2) stimulates robust vascular remodelling in the brain, but it also triggers transient vascular disruption. This raises the fundamental question: is the vascular leak an unwanted side-effect of angio
Externí odkaz:
https://doaj.org/article/cd64671c5826419795e33483102dc817
Autor:
Sebok K. Halder, Richard Milner
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract We recently demonstrated that when mice are exposed to chronic mild hypoxia (CMH, 8% O2), blood vessels in the spinal cord show transient vascular leak that is associated with clustering and activation of microglia around disrupted vessels.
Externí odkaz:
https://doaj.org/article/2f24194a8d4649aebcc9c8f1f3c939df
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract Early in the development of multiple sclerosis (MS) and its mouse model experimental autoimmune encephalomyelitis (EAE), vascular integrity is compromised. This is accompanied by a marked vascular remodeling response, though it is currently
Externí odkaz:
https://doaj.org/article/94b9874d96744978a9d055bd5e825c49
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
BackgroundActivated protein C (APC), a serine protease with antithrombotic effects, protects in animal models of ischemic stroke by suppressing inflammation and enhancing vascular integrity, angiogenesis, neurogenesis and neuroprotection. A small num
Externí odkaz:
https://doaj.org/article/59f9dcb53d1e4dc38a19196a69c08e75
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract While hypoxic pre-conditioning protects against neurological disease the underlying mechanisms have yet to be fully defined. As chronic mild hypoxia (CMH, 10% O2) triggers profound vascular remodeling in the central nervous system (CNS), the
Externí odkaz:
https://doaj.org/article/9f07c3102d7f44f5967c6241c29f03f3