Does biomarker use in oncology improve clinical trial failure risk? A large‐scale analysis

Autor: Ashini Weerasinghe, Sebnem S. Kuzulugil, Kirill Pereverzev, Jayson L. Parker, Bora Caglayan, Stephen Mac, Daniel A. Rubinger, Nicholas Mitsakakis, Ayse Bener, Adam Falconi, Zain Shah, Rohan Tangri, Gilberto Lopes

Publikováno v: Cancer Medicine, Vol 10, Iss 6, Pp 1955-1963 (2021)
Cancer Medicine

Purpose To date there has not been an extensive analysis of the outcomes of biomarker use in oncology. Methods Data were pooled across four indications in oncology drawing upon trial outcomes from www.clinicaltrials.gov: breast cancer, non‐small ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e1182f8e14ab1d2bf40538f129c3a5
https://doaj.org/article/65ec00578e364bdfb9e9535663c41254

List of Contributors

Autor: Abrar Alturkistani, Juanjuan An, Norbert Benda, Karina Bienfait, Adele R. Blackler, Martin Bøgsted, David Brindley, Karl Broich, Rasmus F. Brøndum, Patrick Brunhoeber, Matthew Bureau, Josip Car, Alison Carter, Tara Clarke, June Clements, Darren Cross, Brett Doble, Marisa Dolled-Filhart, Elena Domazetoski, Mark W. Duncan, Ehab A. ElGabry, Aaron R. Ellison, Kenneth Emancipator, Harald Enzmann, Maria Farooq, Janine Feng, Kimberley Foley, Evgenii Generalov, Ning Fei Go, Alexey Goltsov, George A. Green, Maria Hersom, Narimon Honarpour, Lahiru Iddamalgoda, Masayuki Ikeda, Suzanne Jenkins, Jan Trøst Jørgensen, Monesh Kapadia, Sylwia Karwowska, Sebnem S. Kuzulugil, Ching Lam, Jason S. Lewis, Jinbo Li, Oliver Liesenfeld, Gilberto Lopes, Dee Luo, Edward Meinert, Ralf Meyer, Amita Mistry, Nicholas Mitsakakis, Jens Mollerup, Michael C. Montalto, Lauren B. Murata, Muhammed Murtaza, Karsten Bork Nielsen, Saumya Pant, Jayson L. Parker, Patrícia M.R. Pereira, Manjunath Ramarao, Ted Rigl, Oliver Schildgen, Verena Schildgen, Catharina Scholl, Sidney A. Scudder, Donna Seyfried, Abha Sharma, Rumiko Shimazawa, Richard Simon, Shalini Singh, Nicholas B. Sobol, David A. Stanforth, Julia Stingl, Vijayaraghava Seshadri Sundararajan, Prashanth Suravajhala, Alessandra Tosolini, Jeff Tsou, Kathryn M. Tully, Eric E. Walk, Dianna Wu, Xiaolei Xu, Karen Yu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6486bed3732fa46213d3cbf9f5daccdf
https://doi.org/10.1016/b978-0-12-813539-6.00033-x

The Twitter Bullishness Index

Autor: Carl Julien Barrelet, Sebnem S. Kuzulugil, Ayse Bener

Publikováno v: IDEAS

The Twitter Bullishness Index (TBI) has previously been reported to be a social media analytics indicator for the stock market. We explore the different components that shape the TBI. First, we determine the users to be dominated by the US and the En

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c792a324cb07b47695f8e4e4fe1b520f
https://doi.org/10.1145/2938503.2938508

Clinical evaluation of a machine learning-based early warning system for patient deterioration.

Autor: Verma AA; St. Michael's Hospital (Verma, Colacci, Bell, Ailon, Friedrich, Kuzulugil, Yang, Lee, Pou-Prom, Mamdani), Unity Health Toronto; Department of Medicine (Verma, Colacci, Ailon, Friedrich, Lee, Mamdani), and Institute of Health Policy, Management, and Evaluation (Verma, Stukel, Colacci, Murray, Mamdani), and Department of Laboratory Medicine and Pathobiology (Verma, Mamdani), University of Toronto; ICES Central (Stukel); Leslie Dan Faculty of Pharmacy (Mamdani), University of Toronto, Toronto, Ont. amol.verma@mail.utoronto.ca., Stukel TA; St. Michael's Hospital (Verma, Colacci, Bell, Ailon, Friedrich, Kuzulugil, Yang, Lee, Pou-Prom, Mamdani), Unity Health Toronto; Department of Medicine (Verma, Colacci, Ailon, Friedrich, Lee, Mamdani), and Institute of Health Policy, Management, and Evaluation (Verma, Stukel, Colacci, Murray, Mamdani), and Department of Laboratory Medicine and Pathobiology (Verma, Mamdani), University of Toronto; ICES Central (Stukel); Leslie Dan Faculty of Pharmacy (Mamdani), University of Toronto, Toronto, Ont., Colacci M; St. Michael's Hospital (Verma, Colacci, Bell, Ailon, Friedrich, Kuzulugil, Yang, Lee, Pou-Prom, Mamdani), Unity Health Toronto; Department of Medicine (Verma, Colacci, Ailon, Friedrich, Lee, Mamdani), and Institute of Health Policy, Management, and Evaluation (Verma, Stukel, Colacci, Murray, Mamdani), and Department of Laboratory Medicine and Pathobiology (Verma, Mamdani), University of Toronto; ICES Central (Stukel); Leslie Dan Faculty of Pharmacy (Mamdani), University of Toronto, Toronto, Ont., Bell S; St. Michael's Hospital (Verma, Colacci, Bell, Ailon, Friedrich, Kuzulugil, Yang, Lee, Pou-Prom, Mamdani), Unity Health Toronto; Department of Medicine (Verma, Colacci, Ailon, Friedrich, Lee, Mamdani), and Institute of Health Policy, Management, and Evaluation (Verma, Stukel, Colacci, Murray, Mamdani), and Department of Laboratory Medicine and Pathobiology (Verma, Mamdani), University of Toronto; ICES Central (Stukel); Leslie Dan Faculty of Pharmacy (Mamdani), University of Toronto, Toronto, Ont., Ailon J; St. Michael's Hospital (Verma, Colacci, Bell, Ailon, Friedrich, Kuzulugil, Yang, Lee, Pou-Prom, Mamdani), Unity Health Toronto; Department of Medicine (Verma, Colacci, Ailon, Friedrich, Lee, Mamdani), and Institute of Health Policy, Management, and Evaluation (Verma, Stukel, Colacci, Murray, Mamdani), and Department of Laboratory Medicine and Pathobiology (Verma, Mamdani), University of Toronto; ICES Central (Stukel); Leslie Dan Faculty of Pharmacy (Mamdani), University of Toronto, Toronto, Ont., Friedrich JO; St. Michael's Hospital (Verma, Colacci, Bell, Ailon, Friedrich, Kuzulugil, Yang, Lee, Pou-Prom, Mamdani), Unity Health Toronto; Department of Medicine (Verma, Colacci, Ailon, Friedrich, Lee, Mamdani), and Institute of Health Policy, Management, and Evaluation (Verma, Stukel, Colacci, Murray, Mamdani), and Department of Laboratory Medicine and Pathobiology (Verma, Mamdani), University of Toronto; ICES Central (Stukel); Leslie Dan Faculty of Pharmacy (Mamdani), University of Toronto, Toronto, Ont., Murray J; St. Michael's Hospital (Verma, Colacci, Bell, Ailon, Friedrich, Kuzulugil, Yang, Lee, Pou-Prom, Mamdani), Unity Health Toronto; Department of Medicine (Verma, Colacci, Ailon, Friedrich, Lee, Mamdani), and Institute of Health Policy, Management, and Evaluation (Verma, Stukel, Colacci, Murray, Mamdani), and Department of Laboratory Medicine and Pathobiology (Verma, Mamdani), University of Toronto; ICES Central (Stukel); Leslie Dan Faculty of Pharmacy (Mamdani), University of Toronto, Toronto, Ont., Kuzulugil S; St. Michael's Hospital (Verma, Colacci, Bell, Ailon, Friedrich, Kuzulugil, Yang, Lee, Pou-Prom, Mamdani), Unity Health Toronto; Department of Medicine (Verma, Colacci, Ailon, Friedrich, Lee, Mamdani), and Institute of Health Policy, Management, and Evaluation (Verma, Stukel, Colacci, Murray, Mamdani), and Department of Laboratory Medicine and Pathobiology (Verma, Mamdani), University of Toronto; ICES Central (Stukel); Leslie Dan Faculty of Pharmacy (Mamdani), University of Toronto, Toronto, Ont., Yang Z; St. Michael's Hospital (Verma, Colacci, Bell, Ailon, Friedrich, Kuzulugil, Yang, Lee, Pou-Prom, Mamdani), Unity Health Toronto; Department of Medicine (Verma, Colacci, Ailon, Friedrich, Lee, Mamdani), and Institute of Health Policy, Management, and Evaluation (Verma, Stukel, Colacci, Murray, Mamdani), and Department of Laboratory Medicine and Pathobiology (Verma, Mamdani), University of Toronto; ICES Central (Stukel); Leslie Dan Faculty of Pharmacy (Mamdani), University of Toronto, Toronto, Ont., Lee Y; St. Michael's Hospital (Verma, Colacci, Bell, Ailon, Friedrich, Kuzulugil, Yang, Lee, Pou-Prom, Mamdani), Unity Health Toronto; Department of Medicine (Verma, Colacci, Ailon, Friedrich, Lee, Mamdani), and Institute of Health Policy, Management, and Evaluation (Verma, Stukel, Colacci, Murray, Mamdani), and Department of Laboratory Medicine and Pathobiology (Verma, Mamdani), University of Toronto; ICES Central (Stukel); Leslie Dan Faculty of Pharmacy (Mamdani), University of Toronto, Toronto, Ont., Pou-Prom C; St. Michael's Hospital (Verma, Colacci, Bell, Ailon, Friedrich, Kuzulugil, Yang, Lee, Pou-Prom, Mamdani), Unity Health Toronto; Department of Medicine (Verma, Colacci, Ailon, Friedrich, Lee, Mamdani), and Institute of Health Policy, Management, and Evaluation (Verma, Stukel, Colacci, Murray, Mamdani), and Department of Laboratory Medicine and Pathobiology (Verma, Mamdani), University of Toronto; ICES Central (Stukel); Leslie Dan Faculty of Pharmacy (Mamdani), University of Toronto, Toronto, Ont., Mamdani M; St. Michael's Hospital (Verma, Colacci, Bell, Ailon, Friedrich, Kuzulugil, Yang, Lee, Pou-Prom, Mamdani), Unity Health Toronto; Department of Medicine (Verma, Colacci, Ailon, Friedrich, Lee, Mamdani), and Institute of Health Policy, Management, and Evaluation (Verma, Stukel, Colacci, Murray, Mamdani), and Department of Laboratory Medicine and Pathobiology (Verma, Mamdani), University of Toronto; ICES Central (Stukel); Leslie Dan Faculty of Pharmacy (Mamdani), University of Toronto, Toronto, Ont.

Publikováno v: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne [CMAJ] 2024 Sep 15; Vol. 196 (30), pp. E1027-E1037. Date of Electronic Publication: 2024 Sep 15.