Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress.

Autor: Byrne FL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia. Electronic address: frances.byrne@unsw.edu.au., Olzomer EM; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Marriott GR; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Quek LE; School of Mathematics and Statistics, The University of Sydney, Sydney, Australia., Katen A; School of Chemistry, University of New South Wales, Sydney, NSW, Australia., Su J; School of Chemistry, University of New South Wales, Sydney, NSW, Australia., Nelson ME; Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Australia., Hart-Smith G; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Larance M; Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Australia., Sebesfi VF; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Cuff J; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Martyn GE; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Childress E; Department of Chemistry and VT Center for Drug Discovery, Virginia Tech, Blacksburg, VA, USA., Alexopoulos SJ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Poon IK; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia., Faux MC; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia., Burgess AW; Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia., Reid G; Concord Medical School, Asbestos Disease Research Institute, University of Sydney, Australia., McCarroll JA; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia., Santos WL; Department of Chemistry and VT Center for Drug Discovery, Virginia Tech, Blacksburg, VA, USA., Quinlan KG; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Turner N; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia., Fazakerley DJ; Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Australia., Kumar N; School of Chemistry, University of New South Wales, Sydney, NSW, Australia., Hoehn KL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia. Electronic address: k.hoehn@unsw.edu.au.

Publikováno v: Redox biology [Redox Biol] 2020 Jan; Vol. 28, pp. 101374. Date of Electronic Publication: 2019 Nov 05.

Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells.

Autor: Wegner, Marthe-Susanna, Schömel, Nina, Olzomer, Ellen M., Trautmann, Sandra, Olesch, Catherine, Byrne, Frances L., Brüne, Bernhard, Gurke, Robert, Ferreirós, Nerea, Weigert, Andreas, Geisslinger, Gerd, Hoehn, Kyle L.

Publikováno v: Cellular & Molecular Life Sciences; Nov2021, Vol. 78 Issue 21/22, p7025-7041, 17p