Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasms

Autor: Frédéric Féger, Sebastion Létard, Joelle Kersual, Michel Dy, Yael Zermati, Olivier Lortholary, Nathalie Casteran, Michel Arock, Olivier Hermine, Yann Bieche, Karim Dorgham, Paulo De Sepulveda, Patrice Dubreuil, Michel Vidaud, Antoni Ribadeau Dumas, Guy Gorochov, Christophe Parizot

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2003, 22 (5), pp.660-4. ⟨10.1038/sj.onc.1206120⟩
Oncogene, Nature Publishing Group, 2003, 22 (5), pp.660-4. 〈10.1038/sj.onc.1206120〉
Oncogene, 2003, 22 (5), pp.660-4. ⟨10.1038/sj.onc.1206120⟩

Systemic mastocytosis (SM) is a rare disease caused by an abnormal mast cell accumulation in various tissues. Two classes of constitutive activating c-kit mutations are found in SM. The most frequent class occurs in the catalytic pocket coding region

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https://hal.archives-ouvertes.fr/hal-00282566