Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Sebastien Zanella"'
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113085- (2023)
Summary: Persistent sodium current (INaP) in the spinal locomotor network promotes two distinct nonlinear firing patterns: a self-sustained spiking triggered by a brief excitation in bistable motoneurons and bursting oscillations in interneurons of t
Externí odkaz:
https://doaj.org/article/2907ac06fc39438389de5495859e1f14
Autor:
Atsushi Doi, Henner Koch, Frank P. Elsen, Cali Caughie, Alfredo J. Garcia, Jan-Marino Ramirez, Sebastien Zanella
Publikováno v:
The Journal of Physiology. 593:305-319
Prostaglandin E2 (PGE2) augments distinct inspiratory motor patterns, generated within the preBotzinger complex (preBotC), in a dose-dependent way. The frequency of sighs and gasping are stimulated at low concentrations, while the frequency of eupnoe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d692d033c14379d371f0b1c3532645fb
https://doi.org/10.1113/jphysiol.2014.279794
https://doi.org/10.1113/jphysiol.2014.279794
Autor:
Najate Benamer, Sebastien Zanella, Yingtang Shi, Natasha N. Kumar, Christian Gestreau, Sheng Wang, Florian Lesage, Douglas A. Bayliss, David Penton, Patrice G. Guyenet, Jacques Barhanin, Michelle Bévengut
Publikováno v:
The Journal of Neuroscience. 33:16033-16044
Phox2b-expressing glutamatergic neurons of the retrotrapezoid nucleus (RTN) display properties expected of central respiratory chemoreceptors; they are directly activated by CO2/H+via an unidentified pH-sensitive background K+channel and, in turn, fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f384a76a53ffee2629291f8ee188fea8
https://doi.org/10.1523/jneurosci.2451-13.2013
https://doi.org/10.1523/jneurosci.2451-13.2013
Autor:
Alfredo J. Garcia, Sebastien Zanella, Shakil A. Khan, Nanduri R. Prabhakar, Maggie A. Khuu, Tatiana Dashevskiy, Jan-Marino Ramirez
Publikováno v:
Frontiers in Neuroscience
Chronic intermittent hypoxia (CIH) is a common state experienced in several breathing disorders, including obstructive sleep apnea (OSA) and apneas of prematurity. Unraveling how CIH affects the CNS, and in turn how the CNS contributes to apneas is p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3f6d17d0002f18c64cce3377ad37de
https://doi.org/10.3389/fnins.2016.00004
https://doi.org/10.3389/fnins.2016.00004
Autor:
Sebastien Zanella, Jan Ramirez, Shane E. Kruse, Albert Quintana, Richard D. Palmiter, Dong-Hoon Lee, Henner Koch
Publikováno v:
Journal of Clinical Investigation. 122:2359-2368
Leigh syndrome (LS) is a subacute necrotizing encephalomyelopathy with gliosis in several brain regions that usually results in infantile death. Loss of murine Ndufs4, which encodes NADH dehydrogenase (ubiquinone) iron-sulfur protein 4, results in co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fab5844db4d26d00415334c54d6c26
https://doi.org/10.1172/jci62923
https://doi.org/10.1172/jci62923
Autor:
Frédéric Brocard, Michelle Bévengut, Sebastien Zanella, Christian Gestreau, Jacques Barhanin, Yves Cazals
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2015, 6 (1), ⟨10.1038/ncomms9780⟩
Nature Communications, 2015, ⟨10.1038/ncomms9780⟩
Nature Communications, Nature Publishing Group, 2015, ⟨10.1038/ncomms9780⟩
Nature Communications, 2015, 6 (1), ⟨10.1038/ncomms9780⟩
Nature Communications, Nature Publishing Group, 2015, 6 (1), ⟨10.1038/ncomms9780⟩
Nature Communications, 2015, ⟨10.1038/ncomms9780⟩
Nature Communications, Nature Publishing Group, 2015, ⟨10.1038/ncomms9780⟩
Nature Communications, 2015, 6 (1), ⟨10.1038/ncomms9780⟩
In the cochlea, K+ is essential for mechano-electrical transduction. Here, we explore cochlear structure and function in mice lacking K+ channels of the two-pore domain family. A profound deafness associated with a decrease in endocochlear potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebe88cebb4a4fa9a323a406463addd7
https://hal-amu.archives-ouvertes.fr/hal-01791157/document
https://hal-amu.archives-ouvertes.fr/hal-01791157/document
Autor:
Andrew A. Hill, Jan-Marino Ramirez, Ridhdhi Upadhyaya, rd Alfredo J. Garcia, Sebastien Zanella
Publikováno v:
Journal of Neurophysiology
Journal of Neurophysiology, American Physiological Society, 2011, 105 (2), pp.625-39. ⟨10.1152/jn.00237.2010⟩
Journal of Neurophysiology, 2011, 105 (2), pp.625-39. ⟨10.1152/jn.00237.2010⟩
Journal of Neurophysiology, American Physiological Society, 2011, 105 (2), pp.625-39. ⟨10.1152/jn.00237.2010⟩
Journal of Neurophysiology, 2011, 105 (2), pp.625-39. ⟨10.1152/jn.00237.2010⟩
Neurons depend on aerobic metabolism, yet are very sensitive to oxidative stress and, as a consequence, typically operate in a low O2 environment. The balance between blood flow and metabolic activity, both of which can vary spatially and dynamically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6a5fedb9a92827714633ab08c4c916
https://doi.org/10.1152/jn.00237.2010
https://doi.org/10.1152/jn.00237.2010
Autor:
Gérard Hilaire, Sebastien Zanella, Mathias Dutschmann, Nicolas Voituron, Clément Menuet, Anne-Marie Lajard
Publikováno v:
Respiratory Physiology & Neurobiology
Respiratory Physiology & Neurobiology, 2010, 170 (2), pp.173-82. ⟨10.1016/j.resp.2009.12.009⟩
Respiratory Physiology and Neurobiology
Respiratory Physiology and Neurobiology, Elsevier, 2010, 170 (2), pp.173-82. ⟨10.1016/j.resp.2009.12.009⟩
Respiratory Physiology & Neurobiology, 2010, 170 (2), pp.173-82. ⟨10.1016/j.resp.2009.12.009⟩
Respiratory Physiology and Neurobiology
Respiratory Physiology and Neurobiology, Elsevier, 2010, 170 (2), pp.173-82. ⟨10.1016/j.resp.2009.12.009⟩
International audience; Rett syndrome is a neurodevelopmental disease accompanied by complex, disabling symptoms, including breathing symptoms. Because Rett syndrome is caused by mutations in the transcriptional repressor methyl-CpG-binding protein 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9e15641c666a2f8fd96501089bae41
https://doi.org/10.1016/j.resp.2009.12.009
https://doi.org/10.1016/j.resp.2009.12.009
Publikováno v:
Respiratory Physiology & Neurobiology
Respiratory Physiology & Neurobiology, 2009, 168 (1-2), pp.119-124. ⟨10.1016/j.resp.2009.03.010⟩
Respiratory Physiology & Neurobiology, 2009, 168 (1-2), pp.119-124. ⟨10.1016/j.resp.2009.03.010⟩
Prader-Willi syndrome (PWS) is a multigenic disorder caused by the loss of paternal expression of genes in the 15q11-q13 region. It is a complex and progressive disease. From birth, patients present breathing disorders (apnea, rhythm instability, hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46dc55a0c1b1869dc7cdfee76473b16a
https://doi.org/10.1016/j.resp.2009.03.010
https://doi.org/10.1016/j.resp.2009.03.010
Publikováno v:
Respiratory Physiology & Neurobiology. 161:10-15
Apneas are common and prognostically relevant disorders of the central control of breathing, but pharmacological interventions are dissatisfying. The respiratory phenotype of C57BL/6J mice is characterized by the occurrence of spontaneous central apn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c898f9b6948f115414752521872bc6
https://doi.org/10.1016/j.resp.2007.11.001
https://doi.org/10.1016/j.resp.2007.11.001