Výsledky vyhledávání - "Sebastien Robert Stephens"

Charcot Foot and the Osteoclast: More Than Just Cytokines

Autor: Simon Platt, Sebastien Robert Stephens

Publikováno v: Foot & Ankle Orthopaedics
Foot & Ankle Orthopaedics, Vol 4 (2019)

Category: Basic Sciences/Biologics Introduction/Purpose: Charcot foot is a serious complication of diabetes present in up to 13% carrying with high morbidity (dislocations, fractures, deformities) and up to 14% mortality. In Charcot, osteoclasts are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0352788bd6771e4923dd10fb42c886
http://europepmc.org/articles/PMC8696459

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Normalization of Microbiome after Diabetic Foot Ulcer Treatment

Autor: Simon Platt, Sebastien Robert Stephens, Alexandre S. Stephens

Publikováno v: Foot & Ankle Orthopaedics, Vol 4 (2019)
Foot & Ankle Orthopaedics

Category: Diabetes Introduction/Purpose: Diabetic ulcers carry with it extensive morbidity. The microbiome of diabetic foot infections have previously been shown to be polymicrobial. We hypothesized that ulcer treatment would normalize the foot micro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6105ad2736fa7ed7c56152ed87b14e45
https://doaj.org/article/d1db5f1a1d4f49bfbe03a1498548e3c8

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Cardiovascular risk factor mediation of the effects of education and Genetic Risk Score on cardiovascular disease: a prospective observational cohort study of the Framingham Heart Study

Autor: Alexandre S. Stephens, Sebastien Robert Stephens, Katie L Powell

Publikováno v: BMJ Open
BMJ Open, Vol 11, Iss 1 (2021)

ObjectivesLevel of education and genetic risk are key predictors of cardiovascular disease (CVD). While several studies have explored the causal mechanisms of education effects, it remains uncertain to what extent genetic risk is mediated by establis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bbf28ef59bbc5f4e3639f32b81d087a
https://doi.org/10.1136/bmjopen-2020-045210

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Polymeric nanofibrous substrates stimulate pluripotent stem cells to form three-dimensional multilayered patty-like spheroids in feeder-free culture and maintain their pluripotency

Autor: Sebastien Robert Stephens, Patrick Hans-Heinrich Warnke, Mohammad A. Alamein, Ernst J. Wolvetang, Dmitry A. Ovchinnikov, Katherine A. Sanders

Publikováno v: Journal of Tissue Engineering and Regenerative Medicine. 9:1078-1083

Expansion of pluripotent stem cells in defined media devoid of animal-derived feeder cells to generate multilayered three-dimensional (3D) bulk preparations or spheroids, rather than two-dimensional (2D) monolayers, is advantageous for many regenerat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4724fd447ecb2387d1353d86103c96a5
https://doi.org/10.1002/term.1960

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SLC4A2-mediated Cl − /HCO 3 − exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts

Autor: Antonios O. Aliprantis, Andrew K. Stewart, Sebastien Robert Stephens, Seth L. Alper, Lynn Neff, Gary E. Shull, Serhan Zenger, Kelly Tsang, Roland Baron, Fabienne Coury

Publikováno v: Proceedings of the National Academy of Sciences. 110:2163-2168

Bone remodeling requires osteoclasts to generate and maintain an acidified resorption compartment between the apical membrane and the bone surface to solubilize hydroxyapatite crystals within the bone matrix. This acidification process requires ( i )

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd030b9d17d48d28176a273257a861a
https://doi.org/10.1073/pnas.1206392110

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Microtubule Dynamic Instability Controls Podosome Patterning in Osteoclasts through EB1, Cortactin, and Src

Autor: Klemens Rottner, Frank P. L. Lai, Roland Baron, Detina Zalli, Lynn Neff, Sebastien Robert Stephens, Martin Biosse Duplan, William C. Horne, J. Margit Oelkers, Serhan Zenger

In osteoclasts (OCs) podosomes are organized in a belt, a feature critical for bone resorption. Although microtubules (MTs) promote the formation and stability of the belt, the MT and/or podosome molecules that mediate the interaction of the two syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592d87168cefa865f8c488540f82ac46
https://europepmc.org/articles/PMC3911273/

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Antimicrobial peptide coating of dental implants: biocompatibility assessment of recombinant human beta defensin-2 for human cells

Autor: Patrick Hans-Heinrich Warnke, Eske Voss, Paul A.J. Russo, Qin Liu, Sebastien Robert Stephens, Michael Kleine, Hendrik Terheyden

Publikováno v: The International journal of oralmaxillofacial implants. 28(4)

Purpose Artificial materials such as dental implants are at risk of bacterial contamination in the oral cavity. Human beta defensins (HBDs), small cationic antimicrobial peptides that exert a broad-spectrum antibacterial function at epithelial surfac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4e03f8a8d59901cd22d3accc8a734a
https://pubmed.ncbi.nlm.nih.gov/23869355

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Primordium of an artificial Bruch's membrane made of nanofibers for engineering of retinal pigment epithelium cell monolayers

Autor: Mohammad A. Alamein, Qin Liu, Patrick Hans-Heinrich Warnke, Sebastien Robert Stephens, Robert Bourke, Peter Heiner, Stuart Skabo

Publikováno v: Acta biomaterialia. 9(12)

Transplanted retinal pigment epithelium (RPE) cells hold promise for treatment of age-related macular degeneration (AMD) and Stargardt disease (SD), but it is conceivable that the degenerated host Bruch's membrane (BM) as a natural substrate for RPE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5e9af5218f711c875012007f8bf086
https://pubmed.ncbi.nlm.nih.gov/23917149

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Mass production of nanofibrous extracellular matrix with controlled 3D morphology for large-scale soft tissue regeneration

Autor: Stuart Skabo, Qin Liu, Mohammad A. Alamein, Patrick H. Warnke, Sebastien Robert Stephens

Publikováno v: Tissue engineering. Part C, Methods. 19(6)

Biomaterials that mimic the nanofibrous architecture of the natural extracellular matrix (ECM) are in the focus for stem cell hosting or delivery in tissue engineering of multilayered soft tissues such as skin, mucosa, or retina. Synthetic nanofibers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089aaa442cd7b7e992e02689e0524efe
https://pubmed.ncbi.nlm.nih.gov/23102268

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