Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Sebastien Motsch"'
Autor:
Syed M. Faisal, Jarred E. Clewner, Brooklyn Stack, Maria L. Varela, Andrea Comba, Grace Abbud, Sebastien Motsch, Maria G. Castro, Pedro R. Lowenstein
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract Glioblastoma (GBM) remains a challenge in Neuro‐oncology, with a poor prognosis showing only a 5% survival rate beyond two years. This is primarily due to its aggressiveness and intra‐tumoral heterogeneity, which limits complete surgical
Externí odkaz:
https://doaj.org/article/1538c238cfc34c618bb0253cf99982f3
Autor:
Andrea Comba, Maria Luisa Varela, Syed M. Faisal, Clifford C. Abel, II, Anna E. Argento, Wajd N. Al-Holou, Todd C. Hollon, Jacqueline D. Perelman, Patrick J. Dunn, Sebastien Motsch, Maria G. Castro, Pedro R. Lowenstein
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102174- (2023)
Summary: Development of spatial-integrative pre-clinical models is needed for glioblastoma, which are heterogenous tumors with poor prognosis. Here, we present an optimized protocol to generate three-dimensional ex vivo explant slice glioma model fro
Externí odkaz:
https://doaj.org/article/2c43e2be55634ce0ab0275ab171a6f0b
Autor:
Andrea Comba, Syed M. Faisal, Patrick J. Dunn, Anna E. Argento, Todd C. Hollon, Wajd N. Al-Holou, Maria Luisa Varela, Daniel B. Zamler, Gunnar L. Quass, Pierre F. Apostolides, Clifford Abel, Christine E. Brown, Phillip E. Kish, Alon Kahana, Celina G. Kleer, Sebastien Motsch, Maria G. Castro, Pedro R. Lowenstein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
It is essential to improve our understanding of the features that influence aggressiveness and invasion in high grade gliomas (HGG). Here, the authors characterize dynamic anatomical structures in HGG called oncostreams, which are associated with tum
Externí odkaz:
https://doaj.org/article/3b351a9de1174a41bae1168e3664c972
Publikováno v:
Mathematical Biosciences and Engineering, Vol 17, Iss 6, Pp 7692-7707 (2020)
We prove the asymptotic flocking behavior of a general model of swarming dynamics. The model describing interacting particles encompasses three types of behavior: repulsion, alignment and attraction. We refer to this dynamics as the three-zone model.
Externí odkaz:
https://doaj.org/article/fc6ab0106e5f4352b32efcdf7bf7a3a3
Autor:
Andrea Comba, Syed M. Faisal, Maria Luisa Varela, Todd Hollon, Wajd N. Al-Holou, Yoshie Umemura, Felipe J. Nunez, Sebastien Motsch, Maria G. Castro, Pedro R. Lowenstein
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Glioblastomas (GBM) are the most common and aggressive tumors of the central nervous system. Rapid tumor growth and diffuse infiltration into healthy brain tissue, along with high intratumoral heterogeneity, challenge therapeutic efficacy and prognos
Externí odkaz:
https://doaj.org/article/b7e691d8bc6c44449e5536f4139959a2
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007611 (2020)
Modeling cancer cells is essential to better understand the dynamic nature of brain tumors and glioma cells, including their invasion of normal brain. Our goal is to study how the morphology of the glioma cell influences the formation of patterns of
Externí odkaz:
https://doaj.org/article/c72a80a81031409991d893f1e2e88288
Publikováno v:
eLife, Vol 8 (2019)
Efficient transportation is crucial for urban mobility, cell function and the survival of animal groups. From humans driving on the highway, to ants running on a trail, the main challenge faced by all collective systems is how to prevent traffic jams
Externí odkaz:
https://doaj.org/article/99eec500a7a543b9a2e3f786e10fdd49
Autor:
Gregory J. Baker, Viveka Nand Yadav, Sebastien Motsch, Carl Koschmann, Anda-Alexandra Calinescu, Yohei Mineharu, Sandra Ines Camelo-Piragua, Daniel Orringer, Serguei Bannykh, Wesley S. Nichols, Ana C. deCarvalho, Tom Mikkelsen, Maria G. Castro, Pedro R. Lowenstein
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 7, Pp 543-561 (2014)
As glioma cells infiltrate the brain they become associated with various microanatomic brain structures such as blood vessels, white matter tracts, and brain parenchyma. How these distinct invasion patterns coordinate tumor growth and influence clini
Externí odkaz:
https://doaj.org/article/12cd17dca7f14ded948866891f734b16
Autor:
Andrea Comba, Patrick Dunn, Anna E Argento, Padma Kadiyala, Sebastien Motsch, Phillip Kish, Alon Kahana, Daniel Zamler, Karin Muraszko, Maria G Castro, Pedro R Lowenstein
Publikováno v:
Journal of Clinical and Translational Science, Vol 3, Pp 111-111 (2019)
OBJECTIVES/SPECIFIC AIMS: Oncostreams represent a novel growth pattern of GBM. In this study we uncovered the cellular and molecular mechanism that regulates the oncostreams function in GBM growth and invasion. METHODS/STUDY POPULATION: We studied on
Externí odkaz:
https://doaj.org/article/ef69bd0541c1472ca23858f7e1d51710
Collective behavior spans several orders of magnitudes of biological organization, ranging from cell colonies, to flocks of birds, to herds of wildebeests. In this work, we investigate collective motion of glioblastoma cells in an ex-vivo experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e025e7c14d042648d8cdad0b5a5cbe6
https://doi.org/10.1101/2022.07.10.499474
https://doi.org/10.1101/2022.07.10.499474
