Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sebastien G. M. Uzel"'
Autor:
John H. Ahrens, Sebastien G. M. Uzel, Mark Skylar‐Scott, Mariana M. Mata, Aric Lu, Katharina T. Kroll, Jennifer A. Lewis
Publikováno v:
Advanced materials (Deerfield Beach, Fla.). 34(26)
The ability to replicate the 3D myocardial architecture found in human hearts is a grand challenge. Here, the fabrication of aligned cardiac tissues via bioprinting anisotropic organ building blocks (aOBBs) composed of human induced pluripotent stem
Autor:
Bradley Duncan, Robert D. Weeks, Benjamin Barclay, Devon Beck, Patrick Bluem, Roberto Rojas, Maxwell Plaut, John Russo, Sebastien G. M. Uzel, Jennifer A. Lewis, Theodore Fedynyshyn
Publikováno v:
Advanced Materials Technologies. 8:2370011
Publikováno v:
Nature Protocols. 15:421-449
This protocol describes the design, fabrication and use of a 3D physiological and pathophysiological motor unit model consisting of motor neurons coupled to skeletal muscles interacting via the neuromuscular junction (NMJ) within a microfluidic devic
Publikováno v:
Advanced Materials. 35:2206958
Recent advances in computational design and 3D printing enable the fabrication of polymer lattices with high strength-to-weight ratio and tailored mechanics. To date, 3D lattices composed of monolithic materials have primarily been constructed due to
Autor:
Bradley Duncan, Robert D. Weeks, Benjamin Barclay, Devon Beck, Patrick Bluem, Roberto Rojas, Maxwell Plaut, John Russo, Sebastien G. M. Uzel, Jennifer A. Lewis, Theodore Fedynyshyn
Publikováno v:
Advanced Materials Technologies. 8:2201496
Publikováno v:
Advanced Materials Technologies. 7:2101710
Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels
Autor:
Sebastien G. M. Uzel, Jennifer A. Lewis, Mark A. Skylar-Scott, Sarita Damaraju, Ryan L. Truby, Lucy Nam, John H. Ahrens
Publikováno v:
Science Advances
We report a biomanufacturing method for creating perfusable human tissues composed of stem cell–derived organ building blocks.
Engineering organ-specific tissues for therapeutic applications is a grand challenge, requiring the fabrication and
Engineering organ-specific tissues for therapeutic applications is a grand challenge, requiring the fabrication and
Autor:
Viktoria Andreeva, Donald Wlodkowic, Pamela C. Yelick, Sebastien G. M. Uzel, Adrian Devitt-Lee, Jin Akagi, Jean-François Paré, Dany S. Adams, Michael Levin
Publikováno v:
The Journal of Physiology. 594:3245-3270
Key points Xenopus laevis craniofacial development is a good system for the study of Andersen–Tawil Syndrome (ATS)-associated craniofacial anomalies (CFAs) because (1) Kcnj2 is expressed in the nascent face; (2) molecular-genetic and biophysical te
Autor:
Caroline Cvetkovic, Randall Jeffrey Platt, Rashid Bashir, Roger D. Kamm, Sebastien G. M. Uzel, Ritu Raman, Parijat Sengupta
Publikováno v:
Proceedings of the National Academy of Sciences. 113:3497-3502
Complex biological systems sense, process, and respond to their surroundings in real time. The ability of such systems to adapt their behavioral response to suit a range of dynamic environmental signals motivates the use of biological materials for o
Publikováno v:
Science Advances
Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease involving loss of motor neurons (MNs) and muscle atrophy, still has no effective treatment, despite much research effort. To provide a platform for testing drug candidates a