Distinct Amino Acids in the C-Linker Domain of the Arabidopsis K+ Channel KAT2 Determine Its Subcellular Localization and Activity at the Plasma Membrane

Autor: Alain Chavanieu, Carine Alcon, Hervé Sentenac, Manuel Nieves-Cordones, Linda Jeanguenin, Isabelle Gaillard, Isabelle Chérel, Sebastien Estaran, Wojciech Szponarski, Sabine Zimmermann

Publikováno v: Plant Physiology
Plant Physiology, American Society of Plant Biologists, 2014, 164 (3), pp.1415-29. ⟨10.1104/pp.113.229757⟩

Shaker K+ channels form the major K+ conductance of the plasma membrane in plants. They are composed of four subunits arranged around a central ion-conducting pore. The intracellular carboxy-terminal region of each subunit contains several regulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2a2d05fd69f171760ff8f953527079
https://hal.archives-ouvertes.fr/hal-00962147

Kinetics of interaction between ADP-ribosylation factor-1 (Arf1) and the Sec7 domain of Arno guanine nucleotide exchange factor, modulation by allosteric factors, and the uncompetitive inhibitor brefeldin A

Autor: Martine Pugnière, Sana Bakari, Sebastien Estaran, Alain Chavanieu, Jad Rouhana, Stephane Delbecq, André Padilla, Joël Chopineau, Yvan Boublik

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2013, 288 (7), pp.4659-72. ⟨10.1074/jbc.M112.391748⟩

International audience; The GDP/GTP nucleotide exchange of Arf1 is catalyzed by nucleotide exchange factors (GEF), such as Arno, which act through their catalytic Sec7 domain. This exchange is a complex mechanism that undergoes conformational changes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7454a0bc2581b37e9128037548a79e2
https://pubmed.ncbi.nlm.nih.gov/23255605

Computational Design of Chemicals for the Control of Mosquitoes and Their Diseases

Autor: James Devillers

There is a compelling need for new drugs and efficient treatments against mosquito-borne diseases. Environmentally safe, but effective insecticides that address the problems of resistance are required. Computational Design of Chemicals for the Contro