Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Sebastiano Cavallaro"'
Autor:
Giovanna Morello, Maria Guarnaccia, Valentina La Cognata, Valentina Latina, Pietro Calissano, Giuseppina Amadoro, Sebastiano Cavallaro
Publikováno v:
Cells, Vol 12, Iss 18, p 2254 (2023)
Increasing evidence implicates decreased energy metabolism and mitochondrial dysfunctions among the earliest pathogenic events of Alzheimer’s disease (AD). However, the molecular mechanisms underlying bioenergetic dysfunctions in AD remain, to date
Externí odkaz:
https://doaj.org/article/358f217c82594c0390666379dbfcf1f3
Autor:
Valentina La Cognata, Agata Grazia D’Amico, Grazia Maugeri, Giovanna Morello, Maria Guarnaccia, Benedetta Magrì, Eleonora Aronica, Daniel L. Alkon, Velia D’Agata, Sebastiano Cavallaro
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12825 (2023)
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and ultimately fatal neurodegenerative disease, characterized by a progressive depletion of upper and lower motor neurons (MNs) in the brain and spinal cord. The aberrant regulation of seve
Externí odkaz:
https://doaj.org/article/2a9db14d847947fea2e4425e31ddfc26
Autor:
Elisabetta Anna Tendi, Giovanna Morello, Maria Guarnaccia, Valentina La Cognata, Salvatore Petralia, Maria Anna Messina, Concetta Meli, Agata Fiumara, Martino Ruggieri, Sebastiano Cavallaro
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1899 (2023)
Hyperphenylalaninemia (HPA) is the most common inherited amino acid metabolism disorder characterized by serious clinical manifestations, including irreversible brain damage, intellectual deficiency and epilepsy. Due to its extensive genic and alleli
Externí odkaz:
https://doaj.org/article/ac5a963f51804b68b167b03cf3c04b63
Autor:
Valentina La Cognata, Agata Grazia D’Amico, Grazia Maugeri, Giovanna Morello, Maria Guarnaccia, Benedetta Magrì, Eleonora Aronica, Velia D’Agata, Sebastiano Cavallaro
Publikováno v:
Cells, Vol 12, Iss 14, p 1813 (2023)
Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease characterized by progressive depletion of motor neurons (MNs). Recent evidence suggests a role in ALS pathology for the C-X-C motif chemokine receptor 2 (CXCR2), whose
Externí odkaz:
https://doaj.org/article/67e4d3e895fc47febaf52f18148224ab
Autor:
Giovanna Morello, Valentina La Cognata, Maria Guarnaccia, Vincenzo La Bella, Francesca Luisa Conforti, Sebastiano Cavallaro
Publikováno v:
Cells, Vol 12, Iss 14, p 1884 (2023)
Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease with limited treatment options. Diagnosis can be difficult due to the heterogeneity and non-specific nature of the initial symptoms, resulting in delays that compro
Externí odkaz:
https://doaj.org/article/de3c624e6a8447b395751b72fc0d7193
Autor:
Valentina Latina, Anna Atlante, Francesca Malerba, Federico La Regina, Bijorn Omar Balzamino, Alessandra Micera, Annabella Pignataro, Egidio Stigliano, Sebastiano Cavallaro, Pietro Calissano, Giuseppina Amadoro
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9683 (2023)
Beyond deficits in hippocampal-dependent episodic memory, Alzheimer’s Disease (AD) features sensory impairment in visual cognition consistent with extensive neuropathology in the retina. 12A12 is a monoclonal cleavage specific antibody (mAb) that i
Externí odkaz:
https://doaj.org/article/5153491f1e5a4f88bf9d67a72809dd43
Autor:
Giovanna Morello, Valentina La Cognata, Maria Guarnaccia, Velia D’Agata, Sebastiano Cavallaro
Publikováno v:
Cells, Vol 12, Iss 7, p 1057 (2023)
Transcriptional regulation is fundamental to most biological processes and reverse-engineering programs can be used to decipher the underlying programs. In this review, we describe how genomics is offering a systems biology-based perspective of the i
Externí odkaz:
https://doaj.org/article/da164e7f815942c9aa2a75adb667c498
Autor:
Valentina La Cognata, Elisabetta Golini, Rosario Iemmolo, Sara Balletta, Giovanna Morello, Carla De Rosa, Ambra Villari, Sara Marinelli, Valentina Vacca, Gabriele Bonaventura, Paola Dell'Albani, Eleonora Aronica, Fabio Mammano, Silvia Mandillo, Sebastiano Cavallaro
Publikováno v:
Neurobiology of Disease, Vol 160, Iss , Pp 105538- (2021)
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease characterized by depletion of motor neurons (MNs), for which effective medical treatments are still required. Previous transcriptomic analysis revealed the up-regulation o
Externí odkaz:
https://doaj.org/article/eb3bd61adf9447c7a17fb9315972c47d
Autor:
Manuela Ceccarelli, Giorgio D’Andrea, Laura Micheli, Giulia Gentile, Sebastiano Cavallaro, Giuseppe Merlino, Giuliana Papoff, Felice Tirone
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
We have previously generated a mouse model (Ptch1+/−/Tis21KO), which displays high frequency spontaneous medulloblastoma, a pediatric tumor of the cerebellum. Early postnatal cerebellar granule cell precursors (GCPs) of this model show, in conseque
Externí odkaz:
https://doaj.org/article/afb9556bd2cc44309e8ffd3fed0f8c0e
Autor:
Savina Apolloni, Susanna Amadio, Paola Fabbrizio, Giovanna Morello, Antonio Gianmaria Spampinato, Emanuele Claudio Latagliata, Illari Salvatori, Daisy Proietti, Alberto Ferri, Luca Madaro, Stefano Puglisi‐Allegra, Sebastiano Cavallaro, Cinzia Volonté
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 4, Pp 872-893 (2019)
Abstract Background Histamine is an immune modulator, neuroprotective, and remyelinating agent, beneficially acting on skeletal muscles and promoting anti‐inflammatory features in amyotrophic lateral sclerosis (ALS) microglia. Drugs potentiating th
Externí odkaz:
https://doaj.org/article/873f79f0ff7d41ff8561a517fefe8421