Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Sebastiano Battaglia"'
Autor:
Anna Mistarz, Marta Winkler, Sebastiano Battaglia, Song Liu, Alan Hutson, Hanna Rokita, Andrea Gambotto, Kunle O. Odunsi, Prashant K. Singh, A.J. Robert McGray, Jianmin Wang, Danuta Kozbor
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 230-248 (2023)
Tumor antigen-driven responses to weakly immunogenic self-antigens and neoantigens directly affect treatment efficacy following immunotherapy. Using orthotopically grown SV40 T antigen+ ovarian carcinoma in antigen-naive wild-type or TgMISIIR-TAg-Low
Externí odkaz:
https://doaj.org/article/8e193af5311646bdb302dc5359bacd3f
Autor:
Takayoshi Yamauchi, Toshifumi Hoki, Takaaki Oba, Vaibhav Jain, Hongbin Chen, Kristopher Attwood, Sebastiano Battaglia, Saby George, Gurkamal Chatta, Igor Puzanov, Carl Morrison, Kunle Odunsi, Brahm H. Segal, Grace K. Dy, Marc S. Ernstoff, Fumito Ito
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
There is an urgent need to discover blood-based biomarkers to predict response to immune checkpoint inhibitors (ICI). Here the authors show that effective ICI therapy correlates with increased frequency of circulating CX3CR1+CD8+ T cells in preclinic
Externí odkaz:
https://doaj.org/article/5ad9763c2d134ba4b389bb215a94772a
Autor:
Liana Bruggemann, Zackary Falls, William Mangione, Stanley A. Schwartz, Sebastiano Battaglia, Ravikumar Aalinkeel, Supriya D. Mahajan, Ram Samudrala
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 997 (2023)
Pharmacogenomics is a rapidly growing field with the goal of providing personalized care to every patient. Previously, we developed the Computational Analysis of Novel Drug Opportunities (CANDO) platform for multiscale therapeutic discovery to screen
Externí odkaz:
https://doaj.org/article/6ff710e6963a4b23b0482be9c8c3119a
Autor:
Wenjun He, Ravikumar Muthuswamy, Kunle Odunsi, Junko Matsuzaki, Sebastiano Battaglia, Anthony Miliotto, Thinle Chodon, Cheryl Eppolito, Protul Shrikant, AJ Robert McGray, Tsuji Takemasa, Richard Koya, Brian D Lichty
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Externí odkaz:
https://doaj.org/article/e6e918428dd849df8ede21211970c968
Autor:
Adaobi Amobi-McCloud, Ravikumar Muthuswamy, Sebastiano Battaglia, Han Yu, Tao Liu, Jianmin Wang, Vasanta Putluri, Prashant K. Singh, Feng Qian, Ruea-Yea Huang, Nagireddy Putluri, Takemasa Tsuji, Amit A. Lugade, Song Liu, Kunle Odunsi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The immunoregulatory enzyme, indoleamine 2,3-dioxygenase (IDO1) and the PD-1/PD-L1 axis are potent mechanisms that impede effective anti-tumor immunity in ovarian cancer. However, whether the IDO pathway regulates PD-1 expression in T cells is curren
Externí odkaz:
https://doaj.org/article/ef43952e181b43e28a4859495d8c5fc5
Autor:
A. J. Robert McGray, Ruea-Yea Huang, Sebastiano Battaglia, Cheryl Eppolito, Anthony Miliotto, Kyle B. Stephenson, Amit A. Lugade, Gill Webster, Brian D. Lichty, Mukund Seshadri, Danuta Kozbor, Kunle Odunsi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract Background Cancer immunotherapies are emerging as promising treatment strategies for ovarian cancer patients that experience disease relapse following first line therapy. As such, identifying strategies to bolster anti-tumor immunity and lim
Externí odkaz:
https://doaj.org/article/80478d4009594eabbb5adee11254fa6a
Autor:
Song Liu, Junko Matsuzaki, Lei Wei, Takemasa Tsuji, Sebastiano Battaglia, Qiang Hu, Eduardo Cortes, Laiping Wong, Li Yan, Mark Long, Anthony Miliotto, Nicholas W. Bateman, Shashikant B. Lele, Thinle Chodon, Richard C. Koya, Song Yao, Qianqian Zhu, Thomas P. Conrads, Jianmin Wang, George L. Maxwell, Amit A. Lugade, Kunle Odunsi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Background Efficient identification of neoantigen-specific T-cell responses in epithelial ovarian cancer (EOC) remains a challenge. Existing investigations of spontaneous T-cell response to tumor neoepitope in EOC have taken the approach of
Externí odkaz:
https://doaj.org/article/7412361f6c6849f692fd6d0c0b30a2d4
Autor:
Sebastiano Battaglia, Richard C. Koya, Prashant K Singh, Muzamil Y Want, James L Thorne, Ellen Karasik, Bryan Gillard, Eduardo Cortes Gomez, Amit Lugade
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Background Immunotherapy in prostate cancer (PCa) lags behind the progresses obtained in other cancer types partially because of its limited immune infiltration. Tumor-resident immune cells have been detected in the prostate, but the regulatory mecha
Externí odkaz:
https://doaj.org/article/dde393168e8a42cbb5003d09c4f65e30
Autor:
Lei Wei, Sebastiano Battaglia, Yuanquan Yang, Rohit K Jain, Sean T Glenn, Prashant K Singh, Nicholas Hutson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
BackgroundMicrosatellite instability (MSI) occurs in 3% of urothelial carcinomas as a result of germline or somatic loss of function mutation in mismatch repair (MMR) proteins.1 Although MSH4 is a member of the DNA MMR mutS family, the association of
Externí odkaz:
https://doaj.org/article/5456442e7067463b8dd3a5e91e0ac966
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8742 (2021)
Immunotherapy initially demonstrated promising results in prostate cancer (PCa), but the modest or negative results of many recent trials highlight the need to overcome the poor immunogenicity of this cancer. The design of effective therapies for PCa
Externí odkaz:
https://doaj.org/article/5c344ed9dad34c6c9468f7d4881d3c10