Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sebastian Vogg"'
Autor:
Caterina Ruggeri, Hervé Broly, Moritz Wolf, Fabian Feidl, Massimo Morbidelli, Sebastian Vogg, Matevz Podobnik, Alessandro Butté, Nicole Ulmer, Ruben Wälchli, Jonathan Souquet
Publikováno v:
Biotechnology and Bioengineering. 117:1367-1380
Integrated continuous manufacturing is entering the biopharmaceutical industry. The main drivers range from improved economics, manufacturing flexibility, and more consistent product quality. However, studies on fully integrated production platforms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b5bf61c0657a0d478043e8e9d31a46
https://doi.org/10.1002/bit.27296
https://doi.org/10.1002/bit.27296
Autor:
Ismaele Fioretti, Thomas Müller‐Späth, Richard Weldon, Sebastian Vogg, Massimo Morbidelli, Mattia Sponchioni
Publikováno v:
Biotechnology and bioengineering. 119(7)
Oligonucleotides (ONs) are breaking through in the biopharmaceutical industry as a promising class of biotherapeutics. The main success of these molecules is due to their peculiar way of acting in the cellular process, regulating the gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16ad28e05f04e16ec270dc465045e47
https://pubmed.ncbi.nlm.nih.gov/35338661
https://pubmed.ncbi.nlm.nih.gov/35338661
Autor:
James Angelo, Ruben Wälchli, Sebastian Vogg, Fabian Feidl, Zheng Jian Li, Jonathan Souquet, Sanchayita Ghose, Xavier Le Saoût, Hervé Broly, Mariana Ressurreição, Massimo Morbidelli, Xuankuo Xu
Publikováno v:
Biotechnology and Bioengineering, 117 (3)
Monoclonal antibodies (mAbs) and related recombinant proteins continue to gain importance in the treatment of a great variety of diseases. Despite significant advances, their manufacturing can still present challenges owing to their molecular complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800dbbe99e72ee4c9a2a3d29987c228b
https://doi.org/10.1002/bit.27237
https://doi.org/10.1002/bit.27237
Publikováno v:
Biotechnology and Bioengineering. 117:662-672
Aggregates are amongst the most important product-related impurities to be removed during the downstream processing of antibodies due to their potential immunogenicity. Traditional operations use cation-exchange resins in bind-elute mode for their se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679cddac44bfe08fd88d6fe7c2a97021
https://doi.org/10.1002/bit.27235
https://doi.org/10.1002/bit.27235
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 118(9)
The increasing demand for efficient and robust processes in the purification of monoclonal antibodies (mAbs) has recently brought frontal chromatography to the forefront. Applied during the polishing step, it enables the removal of high molecular wei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5f5c2c277c5e101702ed05e9f1e6b3
https://pubmed.ncbi.nlm.nih.gov/33755192
https://pubmed.ncbi.nlm.nih.gov/33755192
Autor:
Antonio Ricci, Sebastian Vogg, Chiara De Luca, Alessandro Buratti, Alberto Cavazzini, Marco Macis, Massimo Morbidelli, Giulio Lievore, Walter Cabri, Martina Catani, Simona Felletti
Publikováno v:
Alma Mater Studiorum Università di Bologna-IRIS
A twin-column Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) process has been developed for the purification of a therapeutic peptide, glucagon, from a crude synthetic mixture. This semi-continuous process uses two identical columns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18cb94423f590f05d61f72da1315d14b
https://pubmed.ncbi.nlm.nih.gov/32709347
https://pubmed.ncbi.nlm.nih.gov/32709347
Publikováno v:
Current Opinion in Chemical Engineering. 22:138-144
Continuous processing of biopharmaceuticals has seen increased interest in recent years due to more competition in the market as well as broader pipelines asking for more flexible and therefore intensified processes. For downstream processing, chroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1de427ab023844548c73601eef6235a9
https://doi.org/10.1016/j.coche.2018.09.001
https://doi.org/10.1016/j.coche.2018.09.001
Autor:
Vania Bertrand, Sebastian Vogg, Massimo Morbidelli, Matthieu Stettler, Miroslav Soos, Hervé Broly, Thomas K. Villiger
Publikováno v:
Journal of Biotechnology. 279:27-36
The pharmaceutical production of recombinant proteins, such as monoclonal antibodies, is rather complex and requires proper development work. Accordingly, it is essential to develop appropriate scale-down models, which can mimic the corresponding pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0afd54663364cfb2b7658f39825bdaf
https://doi.org/10.1016/j.jbiotec.2018.04.015
https://doi.org/10.1016/j.jbiotec.2018.04.015
Autor:
Martin F. Luna, Massimo Morbidelli, Alessandro Butté, Simone Garbellini, Hervé Broly, Sebastian Vogg, Fabian Feidl, Jonathan Souquet
Publikováno v:
Processes
Volume 7
Issue 10
Processes, Vol 7, Iss 10, p 683 (2019)
Processes, 7 (10)
Volume 7
Issue 10
Processes, Vol 7, Iss 10, p 683 (2019)
Processes, 7 (10)
Chromatography is widely used in biotherapeutics manufacturing, and the corresponding underlying mechanisms are well understood. To enable process control and automation, spectroscopic techniques are very convenient as on-line sensors, but their appl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a507e73b928cbd81ed7a16242cb4719e
Autor:
James Angelo, Fabian Feidl, Alessandro Butté, Zheng Jian Li, Kevin Potter, Xuankuo Xu, Martin F. Luna, Massimo Morbidelli, Sanchayita Ghose, Sebastian Vogg, Matevz Podobnik, Elenore Wiggin
Publikováno v:
Journal of Chromatography A. 1625:461261
The high cost of protein A resins drives the biopharmaceutical industry to maximize its lifetime, which is limited by several processes, usually referred to as resin aging. In this work, two model based strategies are presented, aiming to control and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510902efe9bd1c9f9161d90a2a3f5f52
https://doi.org/10.1016/j.chroma.2020.461261
https://doi.org/10.1016/j.chroma.2020.461261