Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sebastian Torke"'
Autor:
Paul Curtis Schöpe, Sebastian Torke, Dennis Kobelt, Benedikt Kortüm, Christoph Treese, Malti Dumbani, Nazli Güllü, Wolfgang Walther, Ulrike Stein
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-26 (2024)
Abstract Cancer metastasis remains the most lethal characteristic of tumors mediating the majority of cancer-related deaths. Identifying key molecules responsible for metastasis, understanding their biological functions and therapeutically targeting
Externí odkaz:
https://doaj.org/article/ef5c02bf7d6c4f209edc204b6f1d2465
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The exact cause of multiple sclerosis (MS) is unknown; however, it is considered to be an inflammatory disease of the central nervous system (CNS) triggered by a combination of both environmental and genetic factors. Vitamin D deficiency is also disc
Externí odkaz:
https://doaj.org/article/6ccfc5a28df74982ae23b68b1557413d
Publikováno v:
JAMA Neurology. 80:404
ImportanceCurrently, disease-modifying therapies for multiple sclerosis (MS) use 4 mechanisms of action: immune modulation, suppressing immune cell proliferation, inhibiting immune cell migration, or cellular depletion. Over the last decades, the rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::440597fcfc48dd10a79991ce2679cac1
https://doi.org/10.1001/jamaneurol.2022.5332
https://doi.org/10.1001/jamaneurol.2022.5332
Autor:
Jasmin Ochs, Nitzan Nissimov, Sebastian Torke, Marie Freier, Katja Grondey, Julian Koch, Matthias Klein, Linda Feldmann, Cathrin Gudd, Tobias Bopp, Silke Häusser-Kinzel, Martin S. Weber
Publikováno v:
Science Translational Medicine. 14
The origin and function of CD20 + T cells are poorly understood. Here, we characterized CD20 + T cells in mice and humans and investigated how they are affected by anti-CD20 antibody treatment. We report that murine CD20 + T cells are unable to endog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28ebd95fdc6fd371f67fb5d6dbc4afd2
https://doi.org/10.1126/scitranslmed.abi4632
https://doi.org/10.1126/scitranslmed.abi4632
Autor:
Wolfgang Brück, Sebastian Torke, Nitzan Nissimov, Zivar Hajiyeva, Katja Grondey, Martin S. Weber, Silke Häusser-Kinzel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Anti-CD20–mediated B cell depletion is a highly effective therapy in MS. However, long-term effects of this approach on the immune system are not yet characterized in detail. After cessation of anti-CD20 treatment, B cells reappear imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0c9a2071207b5d5853f6c9b3508a3f
https://doi.org/10.1073/pnas.2012249117
https://doi.org/10.1073/pnas.2012249117
Autor:
Roxanne Pretzsch, Philipp Haselmayer, Ursula Boschert, Roland Grenningloh, Martin S. Weber, Darius Häusler, Wolfgang Brück, Sebastian Torke
Publikováno v:
Acta Neuropathologica
Anti-CD20-mediated B-cell depletion effectively reduces acute multiple sclerosis (MS) flares. Recent data shows that antibody-mediated extinction of B cells as a lasting immune suppression, harbors the risk of developing humoral deficiencies over tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddf8c7c86d8e48a63a8095f0f063f89
https://pubmed.ncbi.nlm.nih.gov/32761407
https://pubmed.ncbi.nlm.nih.gov/32761407
Autor:
Sebastian Torke, Thomas Bertsch, Evelyn Peelen, Marija Djukic, Scott S. Zamvil, Catherine Larochelle, Martin S. Weber, Roland Nau, Wolfgang Brück, Darius Häusler
Publikováno v:
Brain : a journal of neurology. 142(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15bedd784aea72aed6bdafa53ea0cd10
https://pubmed.ncbi.nlm.nih.gov/31665228
https://pubmed.ncbi.nlm.nih.gov/31665228
Autor:
Marcus Heilmann, Wolfgang Brück, Marija Djukic, Darius Häusler, Matthias Weber, Roland Nau, Martin S. Weber, Evelyn Peelen, Catherine Larochelle, Sebastian Torke, Scott S. Zamvil, Thomas Bertsch
Publikováno v:
Brain. 143:e10-e10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3a77fa05e5912af3bd7548f3cf43e6
https://doi.org/10.1093/brain/awz389
https://doi.org/10.1093/brain/awz389
Autor:
Martin S. Weber, Claude C.A. Bernard, Gildas Lepennetier, Darius Häusler, Wolfgang Brück, Linda Feldmann, Sebastian Torke, Klaus Lehmann-Horn, Scott S. Zamvil, Silke Häusser-Kinzel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 39
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 39
Significance B cell depletion via anti-CD20 monoclonal antibodies is a novel, highly efficient therapy for multiple sclerosis (MS). In a murine MS model, we investigated three mechanistic questions that cannot be addressed in humans. First, we establ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f0694594b122525eb8754b1b108064
https://mediatum.ub.tum.de/doc/1525561/document.pdf
https://mediatum.ub.tum.de/doc/1525561/document.pdf
