Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Sebastian Springer"'
Publikováno v:
npj Climate and Atmospheric Science, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Detecting recurrent weather patterns and understanding the transitions between such regimes are key to advancing our knowledge of the low-frequency variability of the atmosphere and have important implications in terms of weather and climate
Externí odkaz:
https://doaj.org/article/24c00d3a6b7d4c52a32e9c726cfd7c36
Publikováno v:
Frontiers in Applied Mathematics and Statistics, Vol 9 (2023)
We present a Bayesian synthetic likelihood method to estimate both the parameters and their uncertainty in systems of stochastic differential equations. Together with novel summary statistics the method provides a generic and model-agnostic estimatio
Externí odkaz:
https://doaj.org/article/e81988aa493241edb7f6523da549ed00
Autor:
Janine-Denise Kopicki, Ankur Saikia, Stephan Niebling, Christian Günther, Raghavendra Anjanappa, Maria Garcia-Alai, Sebastian Springer, Charlotte Uetrecht
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
The authors present a sensitive and rapid method to determine the binding strength of MHC class 1 peptide complexes using native mass spectrometry.
Externí odkaz:
https://doaj.org/article/ce7fe7856504421aaaf381a0e810a653
Autor:
Katharina Hartman, Guido Steiner, Michel Siegel, Cary M. Looney, Timothy P. Hickling, Katharine Bray-French, Sebastian Springer, Céline Marban-Doran, Axel Ducret
Publikováno v:
Biology, Vol 12, Iss 9, p 1265 (2023)
A critical step in the immunogenicity cascade is attributed to human leukocyte antigen (HLA) II presentation triggering T cell immune responses. The liquid chromatography–tandem mass spectrometry (LC-MS/MS)-based major histocompatibility complex (M
Externí odkaz:
https://doaj.org/article/60580742da114302a53620a33953db56
Autor:
Sebastian Springer, Martin Leitner, Thomas Gruber, Bernd Oberwinkler, Michael Lasnik, Florian Grün
Publikováno v:
Materials, Vol 16, Iss 18, p 6083 (2023)
Additive manufacturing (AM) techniques, such as wire arc additive manufacturing (WAAM), offer unique advantages in producing large, complex structures with reduced lead time and material waste. However, their application in fatigue-critical applicati
Externí odkaz:
https://doaj.org/article/005b3eac4d424275ad4caaa65d66f9ae
Publikováno v:
Current Research in Immunology, Vol 3, Iss , Pp 167-174 (2022)
Complexes of peptides with recombinant major histocompatibility complex class I molecules (rpMHCs) are an important tool for T cell detection, isolation, and activation in cancer immunotherapy. The rapid preparation of rpMHCs is aided by peptide exch
Externí odkaz:
https://doaj.org/article/36de5623a3c3494d9432b59ac70e24ca
Publikováno v:
Current Research in Immunology, Vol 3, Iss , Pp 85-99 (2022)
Through the presentation of peptide antigens to cytotoxic T lymphocytes, major histocompatibility complex (MHC) class I molecules mediate the adaptive immune response against tumors and viruses. Additional non-immunological functions include the hete
Externí odkaz:
https://doaj.org/article/bb58fe4efb714f01bbc5c191928772cc
Autor:
Lucy C. Walters, Daniel Rozbesky, Karl Harlos, Max Quastel, Hong Sun, Sebastian Springer, Robert P. Rambo, Fiyaz Mohammed, E. Yvonne Jones, Andrew J. McMichael, Geraldine M. Gillespie
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110959- (2022)
Summary: MHC-E regulates NK cells by displaying MHC class Ia signal peptides (VL9) to NKG2A:CD94 receptors. MHC-E can also present sequence-diverse, lower-affinity, pathogen-derived peptides to T cell receptors (TCRs) on CD8+ T cells. To understand t
Externí odkaz:
https://doaj.org/article/71476a63d44443faad52b27dcd52bfb2
Autor:
Stephan Niebling, Osvaldo Burastero, Jérôme Bürgi, Christian Günther, Lucas A. Defelipe, Simon Sander, Ellen Gattkowski, Raghavendra Anjanappa, Matthias Wilmanns, Sebastian Springer, Henning Tidow, María García-Alai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Differential scanning fluorimetry (DSF) using the inherent fluorescence of proteins (nDSF) is a popular technique to evaluate thermal protein stability in different conditions (e.g. buffer, pH). In many cases, ligand binding increases therma
Externí odkaz:
https://doaj.org/article/e0885ebc8fc94564a375e92b59216b89
Autor:
Raghavendra Anjanappa, Maria Garcia-Alai, Janine-Denise Kopicki, Julia Lockhauserbäumer, Mohamed Aboelmagd, Janina Hinrichs, Ioana Maria Nemtanu, Charlotte Uetrecht, Martin Zacharias, Sebastian Springer, Rob Meijers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Major Histocompatibility Complex (MHC) class I molecules present tightly binding peptides on the cell surface for recognition by cytotoxic T cells. Here, the authors present the crystal structures of a disulfide-stabilized human MHC class I molecule
Externí odkaz:
https://doaj.org/article/0a9d6a6f48e3448e84d9257ff4977dbc