Zobrazeno 1 - 1
of 1
pro vyhledávání: '"Sebastian Sookup"'
Autor:
Jana Bogum, Robert W. Allcock, Elisabeth K. Martin, Elaine Huston, Tracy Riddell, Daniel M. Houslay, Frank Christian, Miles D. Houslay, Zhong Jiang, Barbara Lindsay, Achamma Abraham, Enno Klussmann, George S. Baillie, David R. Adams, Jonathan P. Day, Sebastian Sookup, Georgina M. Rosair, Robert L. Rae, Diana F. Anthony
Publikováno v:
Journal of Medicinal Chemistry. 54:3331-3347
A survey of PDE4 inhibitors reveals that some compounds trigger intracellular aggregation of PDE4A4 into accretion foci through association with the ubiquitin-binding scaffold protein p62 (SQSTM1). We show that this effect is driven by inhibitor occu