Influence of Heparan Sulfate Proteoglycans and Factor X on species D Human Adenovirus Uptake and Transduction

Autor: Katrin Schröer, Montaha Alshawabkeh, Sebastian Schellhorn, Katrin Bronder, Wenli Zhang, Anja Ehrhardt

Publikováno v: Viruses, Vol 15, Iss 1, p 55 (2022)

More than 100 human adenovirus (Ad) types were identified, of which species D comprises the largest group. Heparan sulfate proteoglycans (HSPGs) were shown to function as cell surface receptors for cell binding and uptake of some Ads, but a systemati

Externí odkaz: https://doaj.org/article/3cd6889d1e644ad3b912105bfbc3b2e1

Adenovirus type 34 and HVR1-deleted Adenovirus type 5 do not bind to PF4: clearing the path towards vectors without thrombosis risk

Autor: Erwan Sallard, Daniel Pembaur, Katrin Schröer, Sebastian Schellhorn, Georgia Koukou, Natascha Schmidt, Wenli Zhang, Florian Kreppel, Anja Ehrhardt

The adenoviral vector based AstraZeneca and Janssen COVID vaccines have been associated with rare cases of thrombosis, a condition which depends on adenovirus binding to the blood protein Platelet Factor 4 (PF4).In order to identify adenoviruses with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34eb0399c9a67c1392f6fff08c250b32
https://doi.org/10.1101/2022.11.07.515483

Identification of novel human adenovirus candidates using the coxsackievirus and adenovirus receptor for cell entry

Autor: Jian Gao, Armin Baiker, Sebastian Schellhorn, Wenli Zhang, Oskar Bunz, Wolfram Volkwein, Anja Ehrhardt, Dominik Jung, Kemal Mese

Publikováno v: Virology Journal
Virology Journal, Vol 17, Iss 1, Pp 1-7 (2020)

Background There are over 100 known human adenovirus (HAdV) types, which are able to cause a broad variety of different self-limiting but also lethal diseases especially in immunocompromised patients. Only limited information about the pathogenesis a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8f6c6d42e0ddd45dedec9c17c5396b
https://doi.org/10.1186/s12985-020-01318-w

Gelfond-Zhang aggregates as propositional formulas

Autor: Sebastian Schellhorn, Torsten Schaub, Pedro Cabalar, Jorge Fandinno

Publikováno v: Artificial Intelligence
Artificial Intelligence, Elsevier, 2019, 274, pp.26-43. ⟨10.1016/j.artint.2018.10.007⟩
Artificial Intelligence, 2019, 274, pp.26-43. ⟨10.1016/j.artint.2018.10.007⟩

International audience; Answer Set Programming (ASP) has become a popular and widespread paradigm for practical Knowledge Representation thanks to its expressiveness and the available enhancements of its input language. One of such enhancements is th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c18ead2fa287ca54c2fbf71a57e61bd
https://hal.archives-ouvertes.fr/hal-02452472

Hybrid Metabolic Network Completion

Autor: Sebastian Schellhorn, Philipp Wanko, Anne Siegel, Clémence Frioux, Torsten Schaub

Publikováno v: Theory and Practice of Logic Programming
Theory and Practice of Logic Programming, 2018, pp.1-23. ⟨10.1017/S1471068418000455⟩
Lecture Notes in Artificial Intelligence
14th International Conference on Logic Programming and Nonmonotonic Reasoning-LPNMR 2017
14th International Conference on Logic Programming and Nonmonotonic Reasoning-LPNMR 2017, Jul 2017, Espoo, Finland. pp.308-321
Theory and Practice of Logic Programming, Cambridge University Press (CUP), 2018, pp.1-23. ⟨10.1017/S1471068418000455⟩
Logic Programming and Nonmonotonic Reasoning ISBN: 9783319616599
LPNMR

Metabolic networks play a crucial role in biology since they capture all chemical reactions in an organism. While there are networks of high quality for many model organisms, networks for less studied organisms are often of poor quality and suffer fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7877bb2aedbdaf2037000fa59c889ef3
https://inria.hal.science/hal-01936778/document