Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Sebastian Scheer"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The immune system comprises a complex yet tightly regulated network of cells and molecules that play a critical role in protecting the body from infection and disease. The activity and development of each immune cell is regulated in a myriad of ways
Externí odkaz:
https://doaj.org/article/27d88c4552d54e72a6d80514f8fae24c
Autor:
Harrison Sudholz, Iona S. Schuster, Momeneh Foroutan, Xavier Sng, Christopher E. Andoniou, Anh Doan, Tania Camilleri, Zihan Shen, Colby Zaph, Mariapia A. Degli-Esposti, Nicholas D. Huntington, Sebastian Scheer
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114333- (2024)
Summary: Histone methyltransferases (HMTs) are crucial in gene regulation and function, yet their role in natural killer (NK) cell biology within the tumor microenvironment (TME) remains largely unknown. We demonstrate that the HMT DOT1L limits NK ce
Externí odkaz:
https://doaj.org/article/c8754c39626e43d7815160610c1f2491
Autor:
Wendy Dankers, Melissa Northcott, Taylah Bennett, Akshay D’Cruz, Rochelle Sherlock, Linden J. Gearing, Paul Hertzog, Brendan Russ, Iolanda Miceli, Sebastian Scheer, Maki Fujishiro, Kunihiro Hayakawa, Keigo Ikeda, Eric F. Morand, Sarah A. Jones
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
SLE is a systemic multi-organ autoimmune condition associated with reduced life expectancy and quality of life. Glucocorticoids (GC) are heavily relied on for SLE treatment but are associated with detrimental metabolic effects. Type 1 interferons (IF
Externí odkaz:
https://doaj.org/article/3505bf1850804a299c6894502a57d398
Autor:
Aidil Zaini, Thomas S. Fulford, Raelene J. Grumont, Jessica Runting, Grace Rodrigues, Judy Ng, Steve Gerondakis, Colby Zaph, Sebastian Scheer
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Group 2 innate lymphoid cells (ILC2s) are emerging as important cellular regulators of homeostatic and disease-associated immune processes. The cytokine interleukin-33 (IL-33) promotes ILC2-dependent inflammation and immunity, with IL-33 having been
Externí odkaz:
https://doaj.org/article/10e7c08fa8f74a6c88f02f11756b0ea2
Autor:
Sebastian Scheer, Suzanne Ackloo, Tiago S. Medina, Matthieu Schapira, Fengling Li, Jennifer A. Ward, Andrew M. Lewis, Jeffrey P. Northrop, Paul L. Richardson, H. Ümit Kaniskan, Yudao Shen, Jing Liu, David Smil, David McLeod, Carlos A. Zepeda-Velazquez, Minkui Luo, Jian Jin, Dalia Barsyte-Lovejoy, Kilian V. M. Huber, Daniel D. De Carvalho, Masoud Vedadi, Colby Zaph, Peter J. Brown, Cheryl H. Arrowsmith
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Protein methyltransferases (PMTs) are epigenetic regulatory enzymes with significant therapeutic relevance. Here the authors describe a collection of chemical inhibitors and antagonists to modulate most of the key methylation marks on histones H3 and
Externí odkaz:
https://doaj.org/article/b9017f82fb1d46769b1e67347ec72d39
Autor:
Liam Kealy, Andrea Di Pietro, Lauren Hailes, Sebastian Scheer, Lennard Dalit, Joanna R. Groom, Colby Zaph, Kim L. Good-Jacobson
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108504- (2020)
Summary: Histone modifiers are essential for the ability of immune cells to reprogram their gene expression during differentiation. The recruitment of the histone methyltransferase DOT1L (disruptor of telomeric silencing 1-like) induces oncogenic gen
Externí odkaz:
https://doaj.org/article/b1306c7f292b4b7d8367714d8c0cab9c
Autor:
Sebastian Scheer, Jessica Runting, Michael Bramhall, Brendan Russ, Aidil Zaini, Jessie Ellemor, Grace Rodrigues, Judy Ng, Colby Zaph
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108505- (2020)
Summary: CD4+ T helper (Th) cell differentiation is controlled by lineage-specific expression of transcription factors and effector proteins, as well as silencing of lineage-promiscuous genes. Lysine methyltransferases (KMTs) comprise a major class o
Externí odkaz:
https://doaj.org/article/d1b3b5c7b154446a82dffd554e7a426f
Autor:
Wilford Goh, Sebastian Scheer, Jacob T. Jackson, Soroor Hediyeh-Zadeh, Rebecca B. Delconte, Iona S. Schuster, Christopher E. Andoniou, Jai Rautela, Mariapia A. Degli-Esposti, Melissa J. Davis, Matthew P. McCormack, Stephen L. Nutt, Nicholas D. Huntington
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108285- (2020)
Summary: Hhex encodes a homeobox transcriptional regulator important for embryonic development and hematopoiesis. Hhex is highly expressed in NK cells, and its germline deletion results in significant defects in lymphoid development, including NK cel
Externí odkaz:
https://doaj.org/article/2bef8f5daa1043aaa96cbe75ddc3a29d
Autor:
Sebastian Scheer, Christine Krempl, Carsten Kallfass, Stefanie Frey, Thilo Jakob, Gabriel Mouahid, Hélène Moné, Annette Schmitt-Gräff, Peter Staeheli, Marinus C Lamers
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112469 (2014)
The human intestinal parasite Schistosoma mansoni causes a chronic disease, schistosomiasis or bilharzia. According to the current literature, the parasite induces vigorous immune responses that are controlled by Th2 helper cells at the expense of Th
Externí odkaz:
https://doaj.org/article/42c063cf76fd4e888682316248887281
Autor:
Nicholas D. Huntington, Joseph Cursons, Terence P. Speed, Axel Kallies, Sebastian Scheer, Corina Behrenbruch, Aline Pfefferle, Ramyar Molania, Momeneh Foroutan
List of the tools and packages used in the manuscript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105c3e53e01ab36d811f8952c611ee06
https://doi.org/10.1158/2326-6066.22543860
https://doi.org/10.1158/2326-6066.22543860
