Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sebastian Richard Scholz"'
Autor:
Gregor Meiss, Oleg Gimadutdinow, Christian Korn, Rudi Lurz, Alfred Pingoud, Sebastian Richard Scholz
Publikováno v:
Journal of Biological Chemistry. 280:6005-6015
DNA fragmentation factor (DFF) is a complex of the DNase DFF40 (CAD) and its chaperone/inhibitor DFF45 (ICAD-L) that can be activated during apoptosis to induce DNA fragmentation. Here, we demonstrate that DFF directly binds to DNA in vitro without p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017b93d9cd143d8afde82a9e18fc3810
https://doi.org/10.1074/jbc.m413035200
https://doi.org/10.1074/jbc.m413035200
Publikováno v:
Nucleic Acids Research. 30:1325-1332
The caspase-activated DNase (CAD) is involved in DNA degradation during apoptosis. Chemical modification of murine CAD with the lysine-specific reagent 2,4,6-trinitrobenzenesulphonic acid and the tyrosine-specific reagent N-acetylimidazole leads to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d051eb6892c117c5e7bd5a843db3b6a8
https://doi.org/10.1093/nar/30.6.1325
https://doi.org/10.1093/nar/30.6.1325
Autor:
Gregor Meiss, Oleg Gimadutdinow, Alfred Pingoud, Adolf Ruiz-Carrillo, Sebastian Richard Scholz, Iwona A. Cymerman, Janusz M. Bujnicki, Patrick Schäfer
Publikováno v:
Journal of molecular biology. 338(2)
Combining sequence analysis, structure prediction, and site-directed mutagenesis, we have investigated the mechanism of catalysis and substrate binding by the apoptotic mitochondrial nuclease EndoG, which belongs to the large family of DNA/RNA non-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99c500ec8bf9fc4503021000aa7f6d5
https://pubmed.ncbi.nlm.nih.gov/15066427
https://pubmed.ncbi.nlm.nih.gov/15066427
Autor:
Gregor Meiss, A. Pingoud, Christian Korn, Oleg Gimadutdinow, Sebastian Richard Scholz, Janusz M. Bujnicki
Publikováno v:
Biochemistry. 42(31)
The caspase-activated DNase (CAD) is an important nuclease involved in apoptotic DNA degradation. Results of a sequence comparison of CAD proteins with beta beta alpha-Me-finger nucleases in conjunction with a mutational and chemical modification ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d638c7c5a60dfad9dfb0dd60d9d2b99
https://pubmed.ncbi.nlm.nih.gov/12899615
https://pubmed.ncbi.nlm.nih.gov/12899615
Autor:
Gregor Meiss, Michael Knoblauch, Sebastian Richard Scholz, Alfred Pingoud, Oleg Gimadutdinow, Christian Korn
Publikováno v:
Nucleic acids research. 30(14)
We show here that co-expression of murine CAD with either ICAD-L or ICAD-S in Escherichia coli as well as mammalian cells leads to a functional DFF complex, which after caspase-3 activation releases a nucleolytically active DNase. The chaperone activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24c898041f1b4e7b6ab33b927e49754
https://pubmed.ncbi.nlm.nih.gov/12967538
https://pubmed.ncbi.nlm.nih.gov/12967538
Publikováno v:
SCOPUS03051048-2001-29-19-SID0035476652
The caspase-activated DNase CAD (DFF40/CPAN) degrades chromosomal DNA during apoptosis. Chemical modification with DEPC inactivates the enzyme, suggesting that histidine residues play a decisive role in the catalytic mechanism of this nuclease. Seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587160b105a2696e9e32fcacda9d9e57
https://openrepository.ru/article?id=709779
https://openrepository.ru/article?id=709779
