High-precision estimation of emitter positions using Bayesian grouping of localizations

Autor: Mohamadreza Fazel, Michael J. Wester, David J. Schodt, Sebastian Restrepo Cruz, Sebastian Strauss, Florian Schueder, Thomas Schlichthaerle, Jennifer M. Gillette, Diane S. Lidke, Bernd Rieger, Ralf Jungmann, Keith A. Lidke

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

Single-molecule localization microscopy relies on stochastic blinking events, treated as independent events without assignment to a particular emitter. Here, BaGoL takes low precision localizations generated from multiple emitter blinkings during DNA

Externí odkaz: https://doaj.org/article/337d012c98924a5584c57b0dfa7a0f77

Inhibition of MK2 suppresses IL-1β, IL-6, and TNF-α-dependent colorectal cancer growth

Autor: Anita L. Ray, Kiersten L. Berggren, Gregory N. Gan, Ellen J. Beswick, Sebastian Restrepo Cruz

Publikováno v: International Journal of Cancer. 142:1702-1711

Colorectal cancer (CRC) development and progression is associated with chronic inflammation. We have identified the MAPK-activated protein kinase 2 (MK2) pathway as a primary mediator of inflammation in CRC. MK2 signaling promotes production of proin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5dc0fd305c57fbcb3f98e8c4c09b5d8f
https://doi.org/10.1002/ijc.31191

MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinoma

Autor: Marc Barry, Antonio Jimeno, Sebastian Restrepo Cruz, Ellen J. Beswick, A. Cowan, Michelle A. Ozbun, Dennis J. McCance, Michael D Hixon, Stephen B. Keysar, Jacqueline James, Stephanie G Craig, Gregory N Gan, Kiersten L. Berggren

Publikováno v: Berggren, K L, Restrepo Cruz, S, Hixon, M D, Cowan, A T, Keysar, S B, Craig, S, James, J, Barry, M, Ozbun, M A, Jimeno, A, McCance, D J, Beswick, E J & Gan, G N 2019, ' MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinoma ', Oncogene, vol. 38, pp. 7329–7341 . https://doi.org/10.1038/s41388-019-0945-9
Oncogene

Radiation therapy (RT) is a cornerstone of treatment in the management of head and neck squamous cell carcinomas (HNSCC), yet treatment failure and disease recurrence are common. The p38/MK2 pathway is activated in response to cellular stressors, inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9edf0f566e912669286af205fade639f
https://pure.qub.ac.uk/en/publications/mapkapk2-mk2-inhibition-mediates-radiationinduced-inflammatory-cytokine-production-and-tumor-growth-in-head-and-neck-squamous-cell-carcinoma(52cd578e-9fdb-4520-b722-2791c8d49345).html