The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia

Autor: Jan Kremers, Hanns Hatt, Esther Asan, Sebastian Rasche, Eva M. Neuhaus, Siv Strömberg, Andreas Gießl, Manfred W. Kilimann, Johann Helmut Brandstätter, Jenny Atorf, Denis Hervé, Stefan Kurtenbach

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7, pp.8409. ⟨10.1038/s41598-017-08543-4⟩
Scientific Reports, 2017, 7, pp.8409. ⟨10.1038/s41598-017-08543-4⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-19 (2017)

BEACH domain proteins are involved in membrane protein traffic and human diseases, but their molecular mechanisms are not understood. The BEACH protein LRBA has been implicated in immune response and cell proliferation, and human LRBA mutations cause

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af828fb794eba82ac38befa9c5937606
https://doi.org/10.1038/s41598-017-08543-4

The scaffold protein MUPP1 regulates odorant-mediated signaling in olfactory sensory neurons

Autor: Sabrina, Baumgart, Fabian, Jansen, Willem, Bintig, Benjamin, Kalbe, Christian, Herrmann, Fabian, Klumpers, S David, Köster, Paul, Scholz, Sebastian, Rasche, Ruth, Dooley, Nils, Metzler-Nolte, Marc, Spehr, Hanns, Hatt, Eva M, Neuhaus

Publikováno v: Journal of cell science. 127(Pt 11)

The olfactory signal transduction cascade transforms odor information into electrical signals by a cAMP-based amplification mechanism. The mechanisms underlying the very precise temporal and spatial organization of the relevant signaling components r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::152ba3b6736a021212cf71ed47cc7c46
https://pubmed.ncbi.nlm.nih.gov/24652834

Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1

Autor: Ruth, Dooley, Sabrina, Baumgart, Sebastian, Rasche, Hanns, Hatt, Eva M, Neuhaus

Publikováno v: The FEBS journal. 276(24)

The unique ability of mammals to detect and discriminate between thousands of different odorant molecules is governed by the diverse array of olfactory receptors expressed by olfactory sensory neurons in the nasal epithelium. Olfactory receptors cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03d4fc441d15036464a5447249cf7d67
https://pubmed.ncbi.nlm.nih.gov/19909339