Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sebastian R. Nielsen"'
Autor:
Maria Rafaeva, Adina R. D. Jensen, Edward R. Horton, Kamilla W. Zornhagen, Jan E. Strøbech, Lutz Fleischhauer, Alejandro E. Mayorca-Guiliani, Sebastian R. Nielsen, Dina S. Grønseth, Filip Kuś, Erwin M. Schoof, Luis Arnes, Manuel Koch, Hauke Clausen-Schaumann, Valerio Izzi, Raphael Reuten, Janine T. Erler
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The desmoplastic reaction observed in many cancers is a hallmark of disease progression and prognosis, particularly in breast and pancreatic cancer. Stromal-derived extracellular matrix (ECM) is significantly altered in desmoplasia, and as such plays
Externí odkaz:
https://doaj.org/article/1b359b8013e44394a924f6031f8d7cb2
Autor:
Jan E. Strøbech, Pietro Giuriatti, Rikke Stagaard, Paulo De Sepulveda, Sebastian R. Nielsen, Janine T. Erler
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Patients with pancreatic ductal adenocarcinoma (PDAC) have a dismal 5-year survival rate of less than 10%, predominantly due to delayed diagnosis and a lack of effective treatment options. In the PDAC tumor microenvironment (TME), neutrophils are amo
Externí odkaz:
https://doaj.org/article/52604e17191a4993b5ac038c3904f7b0
Autor:
Sebastian R. Nielsen, Jan E. Strøbech, Edward R. Horton, Rene Jackstadt, Anu Laitala, Marina C. Bravo, Giorgia Maltese, Adina R. D. Jensen, Raphael Reuten, Maria Rafaeva, Saadia A. Karim, Chang-Il Hwang, Luis Arnes, David A. Tuveson, Owen J. Sansom, Jennifer P. Morton, Janine T. Erler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Tumor associated neutrophils have been correlated with poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC). Here the authors show that the tyrosine kinase inhibitor lorlatinib modulates neutrophil development and recruitment in th
Externí odkaz:
https://doaj.org/article/80c3347050694832b4503df3a10d5b8d
Publikováno v:
Mediators of Inflammation, Vol 2017 (2017)
Macrophages are one of the most abundant immune cells in the tumour microenvironment of solid tumours and their presence correlates with reduced survival in most cancers. Macrophages are present at all stages of tumour progression and stimulate angio
Externí odkaz:
https://doaj.org/article/5e53e19b351f47c6bb853a33994bbd76
Autor:
Brian D. Brown, Miriam Merad, Alessia Baccarini, Luisanna Pia, C. Matthias Wilk, Jalal A. Khan, Ashwitha Lakshmi, Adam Marks, Sebastian R. Nielsen, Gurkan Mollaoglu, Jaime Mateus-Tique, Alfonso R. Sánchez-Paulete
Supplementary Figure from Targeting Macrophages with CAR T Cells Delays Solid Tumor Progression and Enhances Antitumor Immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ae1fb86b9b4e47c42c3016d0ee519d
https://doi.org/10.1158/2326-6066.22544988
https://doi.org/10.1158/2326-6066.22544988
Autor:
Brian D. Brown, Miriam Merad, Alessia Baccarini, Luisanna Pia, C. Matthias Wilk, Jalal A. Khan, Ashwitha Lakshmi, Adam Marks, Sebastian R. Nielsen, Gurkan Mollaoglu, Jaime Mateus-Tique, Alfonso R. Sánchez-Paulete
Supplementary Table from Targeting Macrophages with CAR T Cells Delays Solid Tumor Progression and Enhances Antitumor Immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078fc08cb5a3414d8abc628523f3935c
https://doi.org/10.1158/2326-6066.22544985.v1
https://doi.org/10.1158/2326-6066.22544985.v1
Autor:
Brian D. Brown, Miriam Merad, Alessia Baccarini, Luisanna Pia, C. Matthias Wilk, Jalal A. Khan, Ashwitha Lakshmi, Adam Marks, Sebastian R. Nielsen, Gurkan Mollaoglu, Jaime Mateus-Tique, Alfonso R. Sánchez-Paulete
Tumor-associated macrophages (TAM) are one of the most abundant cell types in many solid tumors and typically exert protumor effects. This has led to an interest in macrophage-depleting agents for cancer therapy, but approaches developed to date have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe995df29750a8567f13a070646ba95
https://doi.org/10.1158/2326-6066.c.6550818.v1
https://doi.org/10.1158/2326-6066.c.6550818.v1
Autor:
Michael C. Schmid, Ainhoa Mielgo, David A. Tuveson, Daniel H. Palmer, Fiona Campbell, Trish Murray, Arthur Taylor, Dannielle D. Engle, Muhammad S. Ahmed, Meirion L. Raymant, Sebastian R. Nielsen, Carolyn Rainer, Valeria Quaranta
The ability of disseminated cancer cells to evade the immune response is a critical step for efficient metastatic progression. Protection against an immune attack is often provided by the tumor microenvironment that suppresses and excludes cytotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c50fc90d028394b7e23b08fae8143f
https://doi.org/10.1158/0008-5472.c.6510191.v1
https://doi.org/10.1158/0008-5472.c.6510191.v1
Autor:
Ainhoa Mielgo, Michael C. Schmid, Fiona Campbell, David A. Tuveson, Thomas Bogenrieder, Azzam Taktak, Sarah E. Coupland, Pedro A. Perez-Mancera, Danielle D. Engle, Ulrike Weyer-Czernilofsky, Valeria Quaranta, Sebastian R. Nielsen, Carolyn Rainer, Muhammad S. Ahmed, Almudena Santos, Lucy Ireland
Fig. S1. Primary M2-like macrophages express IGF-1 and IGF-2. Fig. S2. In the absence of chemotherapy, addition of MCM, IGF blockade or recombinant IGF does not affect proliferation or survival of pancreatic cancer cells. Fig.S3. MCM enhances resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06902771ee91c13e027d15cd82063e3a
https://doi.org/10.1158/0008-5472.22412769.v1
https://doi.org/10.1158/0008-5472.22412769.v1
Autor:
Ainhoa Mielgo, Michael C. Schmid, Fiona Campbell, David A. Tuveson, Thomas Bogenrieder, Azzam Taktak, Sarah E. Coupland, Pedro A. Perez-Mancera, Danielle D. Engle, Ulrike Weyer-Czernilofsky, Valeria Quaranta, Sebastian R. Nielsen, Carolyn Rainer, Muhammad S. Ahmed, Almudena Santos, Lucy Ireland
Supplementary Figure legends. Table S1. Clinical information from 40 consented PDA patient samples. Table S2. Clinical information from 16 consented PDA patient samples. Supplementary Materials and Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05193f27a952663e6bd42aea594e452f
https://doi.org/10.1158/0008-5472.22412772.v1
https://doi.org/10.1158/0008-5472.22412772.v1