ASC filament formation serves as a signal amplification mechanism for inflammasomes

Autor: Mathias S. Dick, Lorenzo Sborgi, Sebastian Rühl, Sebastian Hiller, Petr Broz

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

Inflammasomes regulate IL-1β family maturation and pyroptosis. Here the authors show that ASC oligomerization and the formation of ASC specks are needed for IL-1β processing, but are not required for pyroptosis, indicating distinct inflammasome reg

Externí odkaz: https://doaj.org/article/846a5b7a13d34863b94bbdb0151a87c3

Reproducibility of CT-based opportunistic vertebral volumetric bone mineral density measurements from an automated segmentation framework

Autor: Jannis Bodden, Philipp Prucker, Anjany Sekuboyina, Malek El Husseini, Katharina Grau, Sebastian Rühling, Egon Burian, Claus Zimmer, Thomas Baum, Jan S. Kirschke

Publikováno v: European Radiology Experimental, Vol 8, Iss 1, Pp 1-12 (2024)

Abstract Background To investigate the reproducibility of automated volumetric bone mineral density (vBMD) measurements from routine thoracoabdominal computed tomography (CT) assessed with segmentations by a convolutional neural network and automated

Externí odkaz: https://doaj.org/article/75e1770622e04bf5984ef6896535565d

Sex differences and age-related changes in vertebral body volume and volumetric bone mineral density at the thoracolumbar spine using opportunistic QCT

Autor: Sebastian Rühling, Jonas Dittmann, Tobias Müller, Malek El Husseini, Jannis Bodden, Moritz R. Hernandez Petzsche, Maximilian T. Löffler, Nico Sollmann, Thomas Baum, Vanadin Seifert-Klauss, Maria Wostrack, Claus Zimmer, Jan S. Kirschke

Publikováno v: Frontiers in Endocrinology, Vol 15 (2024)

ObjectivesTo quantitatively investigate the age- and sex-related longitudinal changes in trabecular volumetric bone mineral density (vBMD) and vertebral body volume at the thoracolumbar spine in adults.MethodsWe retrospectively included 168 adults (m

Externí odkaz: https://doaj.org/article/811586463ca2409b95d65be71b83ddfb

Activation of the cAMP/protein kinase A signalling pathway by coronin 1 is regulated by cyclin-dependent kinase 5 activity

Autor: Rajesh Jayachandran, Xiaolong Liu, Jean Pieters, Vera Studer, Sebastian Rühl, Somdeb BoseDasgupta, Michael Stiess

Publikováno v: FEBS letters

Coronins constitute a family of conserved proteins expressed in all eukaryotes that have been implicated in the regulation of a wide variety of cellular activities. Recent work showed an essential role for coronin 1 in the modulation of the cAMP/PKA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e667e99173eefe49311f639c5e3ce0
https://doi.org/10.1002/1873-3468.12046

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

Autor: Mathias S. Dick, Mélanie Rigard, Sébastien Dussurgey, Klaus Pfeffer, Anne Kistner, Roland F. Dreier, Leonie Anton, Pierre Wallet, Masahiro Yamamoto, Stéphanie Costanzo, Etienne Meunier, Sebastian Rühl, Daniel Degrandi, Petr Broz, Thomas Henry

Publikováno v: Nature Immunology
Nature Immunology, Nature Publishing Group, 2015, 16 (5), pp.476-484. ⟨10.1038/ni.3119⟩
Nature Immunology, 2015, 16 (5), pp.476-484. ⟨10.1038/ni.3119⟩
NATURE IMMUNOLOGY
Nature immunology

The AIM2 inflammasome detects double-stranded DNA in the cytosol and induces caspase-1-dependent pyroptosis as well as release of the inflammatory cytokines interleukin 1β (IL-1β) and IL-18. AIM2 is critical for host defense against DNA viruses and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e43ebc24747107e6cc4da985354937
https://doi.org/10.1038/ni.3119